Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder.
|Title||Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Chen LM, Tollenaar MS, Dass SAHari, Bouvette-Turcot A-A, Pokhvisneva I, Gaudreau H, Parent C, Diorio J, McEwen LM, MacIsaac JL, Kobor MS, Beijers R, de Weerth C, Silveira PP, Karama S, Meaney MJ, O'Donnell K|
|Corporate Authors||MAVAN Study Team|
|Date Published||2020 12|
|Keywords||Attention Deficit Disorder with Hyperactivity, Child, Depression, Female, Genomics, Humans, Mental Health, Mothers, Pregnancy|
Maternal antenatal depression strongly influences child mental health but with considerable inter-individual variation that is, in part, linked to genotype. The challenge is to effectively capture the genotypic influence. We outline a novel approach to describe genomic susceptibility to maternal antenatal depression focusing on child emotional/behavioral difficulties. Two cohorts provided measures of maternal depression, child genetic variation, and child mental health symptoms. We constructed a conventional polygenic risk score (PRS) for attention-deficit/hyperactivity disorder (ADHD) (PRSADHD) that significantly moderated the association between maternal antenatal depression and internalizing problems at 60 months (p = 2.94 × 10-4, R2 = .18). We then constructed an interaction PRS (xPRS) based on a subset of those single nucleotide polymorphisms from the PRSADHD that most accounted for the moderation of the association between maternal antenatal depression and child outcome. The interaction between maternal antenatal depression and this xPRS accounted for a larger proportion of the variance in child emotional/behavioral problems than models based on any PRSADHD (p = 5.50 × 10-9, R2 = .27), with similar findings in the replication cohort. The xPRS was significantly enriched for genes involved in neuronal development and synaptic function. Our study illustrates a novel approach to the study of genotypic moderation on the impact of maternal antenatal depression on child mental health and highlights the utility of the xPRS approach. These findings advance our understanding of individual differences in the developmental origins of mental health.
|Alternate Journal||Dev Psychopathol|
|Grant List||/ / Canadian Institutes for Health Research / International|