Martin Lepage

Clinical Research

Martin Lepage, PhD

F-1143, Frank B. Common Pavilion

6875 Boulevard LaSalle
Montréal, QC
H4H 1R3

(514) 761-6131 x4393

(514) 888-4099

Research area: 
Clinical Research / Human Research

Research Theme: 
Psychosis and Neurodevelopmental Disorders

FRQS Research Chair in cognitive neuroscience and schizophrenia

​Researcher, Douglas Research Centre
Deputy Scientific Director, Douglas Research Centre
Clinical Psychologist, Douglas Mental Health University Institute
James McGill Professor, Department of Psychiatry, McGill University
Associate Professor, Department of Psychology, McGill University

CRISP group: Comprehensive research into schizophrenia and psychosis

The CRISP group is currently exploring several inter-related dimensions of schizophrenia and psychosis through the use of various clinical, neurocognitive and neuroimaging techniques, such as:

    MRI and fMRI
    Neuropsychological testing
    Cognitive behavioural therapy
    Cognitive remediation

Our approach is motivated by a desire to better understand negative and cognitive symptoms that often characterize schizophrenia (e.g. memory difficulties, avolition, anhedonia, poor insight, etc.) and to develop research programs that will have significant clinical applications.

More specifically, the laboratory studies:

    Neurocognitive and neuroimaging markers of remission in first episode psychosis
    Biological and psychological determinants of insight in schizophrenia
    Cognitive behavioural therapy for social anxiety in psychosis
    Cognitive remediation therapy in schizophrenia
    Cognitive neuroscience of episodic memory in schizophrenia

1. Benoit, A., Malla, A.K., Joober, R., Bherer, L. &Lepage, M. (in press). Cognitive deficits characterization using the CogState Research Battery in first-episode psychosis patients. Schizophrenia Research: Cognition.

2. Buchy, L., Hawco, C., Joober, R., Malla, A.&Lepage, M. (in press). Cognitive insight in first-episode psychosis: Further evidence for a role of the ventrolateral prefrontal cortex. Schizophrenia Research.

3. Lepage, M., Hawco, C. & *Bodnar M. (in press). Relational memory: a neurocognitive marker of schizophrenia? JAMA Psychiatry.

4. Montreuil, T., Malla, A.K., Joober, R., Bélanger, C., Myhr, G. &Lepage, M. (in press) Manualized group cognitive behavioral intervention for social anxiety in First- Episode Psychosis. International Journal of Group Psychotherapy.

5. Hawco, C., Buchy, L., Bodnar, M., Izadi, S., Dell’Elce, J., Messina, K., Joober, R., Malla, A. &Lepage, M. (2015). Source retrieval is not properly differentiated from object retrieval in early schizophrenia: an fMRI study using virtual reality. NeuroImage Clinical, 7:336-346.

6. Benoit, A., *Bodnar, M., Malla, A.K., Joober, R., Bherer, L. &Lepage, M. (2014). Changes in memory performance over a 12-month period in relation to achieving symptomatic remission after a first episode psychosis. Schizophrenia Research, 153:103-108.

7. Bodnar, M., *Hovington, C.L., *Buchy, L., Malla, A.K., Joober, R. &Lepage, M. (2014). Cortical thinning in temporo-parietal junction in non-affective first-episode of psychosis patients with persistent negative symptoms. PlosOne, 9(6): e101372.

8. Lepage, M., Bodnar M., & Bowie, C. (2014). Neurocognition: Clinical and Functional Outcomes in Schizophrenia. Canadian Journal of Psychiatry, 59: 5-12

9. Cassidy, C., Buchy, L., Bodnar, M., Dell’Elce, Choudry, Z., Fathalli, F., Fox, R., Sengupta, S., Iyer, S., Ad-Dab’bagh, Y., Evans, A., Malla, A., Lepage, M. & Joober, R. (2014). Association of a risk allele of ANK3 with lower cognitive performance and cortical thinning in patients with first episode psychosis. Journal of Psychiatry & Neuroscience, 39:31-39.

10. Hawco, C., Berlim, M.T. &Lepage, M. (2013). The dorsolateral prefrontal cortex plays a role in self-initiated elaborative cognitive processing during episodic memory encoding: rTMS evidence. PlosOne, 8(9): e73789.

11. Hovington, C.L., *Bodnar, M, Joober, R., Malla, A. &Lepage, M. (2013). Impairment in verbal memory in first episode psychosis patients with persistent negative symptoms. Schizophrenia Research, 147:223-229.

12. Bodnar, M., Achim, A.M., Malla, A., Joober, R., Benoit, A., Sutton, H. & Lepage, M. (2012). Functional magnetic resonance imaging correlates of memory encoding in relation to achieving remission in first-episode schizophrenia. British Journal of Psychiatry, 200:300-307.

13. Hovington, C.L., Bodnar, M, Joober, R., Malla, A. & Lepage, M. (2012). Identifying persistent negative symptoms in first episode psychosis. BMC Psychiatry, 12(1):224. DOI:10.1186/1471-244X-12-224.

14. Lepage, M., Sergerie, K., Benoit, A., Czechowska, Y., Dickie, E. & Armony, J.L. (2011). Emotional face processing and flat affect in schizophrenia: Functional and structural neural correlates. Psychological Medicine, 41:1833-1844.

James McGill Professor Award (2013-2020)
FRQS Senior Research Scholar (2010-2014)
Clinical Scholarship, Beck Institute for Cognitive Therapy & Research (2010)
Dr. Heinz Lehmann Award, Douglas Institute Foundation (2010)
Diplomé émérite: Department of Psychology, Université du Quebec à Montreal (2010)
Canadian College of Neuropsychopharmacology (CCNP) - Young Investigator Award (2007)
Dean’s Research Recognition Award, Faculty of Medicine, McGill University (2006)
FRQS Research Scholar Junior 2 (2006 - 2010)
FRQS Research Scholar Junior 1(2002 - 2006)
National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award (2002)

Lab Manager:

Karyne Anselmo, M.Sc; ext. 3296;

Research Coordinators:

Danielle Penney, B.A.; ext. 3485;
Lucile Rapin, Ph.D.; ext. 3478;

Research Assistant: 

Casandra Roy Gelencser, B.A.; ext. 3386;

Graduate Students:


Recent publications