@article{pmid42413520,

title = {Investing early in youth mental health: from promise to population evidence},

author = {Marie-Claude Geoffroy and Sylvana M Côté},

doi = {10.1016/S2215-0366(26)00199-9},

issn = {2215-0374},

year  = {2026},

date = {2026-08-01},

journal = {Lancet Psychiatry},

volume = {13},

number = {8},

pages = {629--631},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42484771,

title = {Mental health status of sexually diverse youth at age 23: Cross-sectional data from the Quebec Longitudinal Study of Child Development},

author = {Alicia Martineau and Sasha MacNeil and Srividya N Iyer and Kira London-Nadeau and Lauren Anzarouth and Élise Chartrand and Ian Colman and Massimiliano Orri and Nicholas Chadi and Isabelle Ouellet-Morin and Natalie Castellanos Ryan and Annie Pullen Sansfaçon and Robert-Paul Juster and Marie-Claude Geoffroy},

doi = {10.17269/s41997-026-01235-5},

issn = {1920-7476},

year  = {2026},

date = {2026-07-01},

journal = {Can J Public Health},

abstract = {OBJECTIVES: Canadian population-based data show that sexually diverse youth face greater mental health challenges than their heterosexual peers. However, nuances within sexual diversity-particularly among mostly heterosexual persons-are overlooked, and psychotic-like experiences remain underexplored. We examined the mental health of sexually diverse young adults from Quebec, spanning indicators from well-being to psychotic-like experiences.nnMETHODS: Data were drawn from 1324 youth from the Quebec Longitudinal Study of Child Development-a representative cohort born in 1997/98 and followed up until age 23. Participants self-reported their sexual orientation and mental health across nine indicators: suicidality, depression, anxiety, binge drinking, cannabis, other drug use, psychotic-like experiences, well-being, and help-seeking. Standardized mean differences (SMD) assessed group differences, stratified by assigned sex at birth and sexual orientation.nnRESULTS: A total of 324 (24.47%) youth identified as non-heterosexual. These youth reported poorer outcomes across all indicators (SMDs ranged from 0.19 for cannabis use to 0.52 for suicidality) and had higher odds of seeking psychological help (OR = 2.09, 95% CI [1.52-2.89]). Sexually diverse females reported poorer outcomes across all indicators compared to heterosexual females. Sexually diverse males had elevated risks for suicidality, depression, anxiety, and reduced well-being compared to heterosexual males. Mostly heterosexual (N = 156, 48.15%) and bisexual persons (N = 85, 26.23%) reported more symptoms than heterosexuals.nnCONCLUSION: Despite Canada's inclusive stance on sexual diversity, sexually diverse youth-especially those identifying as mostly heterosexual and bisexual-continue to face significant mental health disparities. Our findings highlight the need for accessible, tailored mental health services to support this population.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41865642,

title = {Prevalence and mental health correlates of non-suicidal self-injury in elementary school children},

author = {Shadi Hadj-Youssef and Alessia Civita and Elise Chartrand and Catherine Malboeuf-Hurtubise and Julia Fuoco and Tianna Loose and Isabelle Ouellet-Morin and Nancy Heath and Nathalie Maltais and Imke Baetens and Michel Spodenkiewicz and Sylvana Côté and Marie-Claude Geoffroy},

doi = {10.1016/j.psychres.2026.117097},

issn = {1872-7123},

year  = {2026},

date = {2026-06-01},

journal = {Psychiatry Res},

volume = {360},

pages = {117097},

abstract = {BACKGROUND: Non-suicidal self-injury (NSSI) is relatively common in adolescence and associated with mental health symptoms, yet the prevalence of NSSI and mental health correlates in childhood remain poorly understood.nnOBJECTIVE: Document the lifetime prevalence of NSSI in elementary-school children and concurrent associations with self- and teacher-reported mental health symptoms and peer problems.nnMETHODS: Cross sectional analysis of 859 children (mean age=10.9 years; n = 419 males) from 33 elementary schools in Quebec, Canada who completed a self-report measure of NSSI (5-item Self-Mutilation subscale; Self Harm Inventory) and self- and teacher-report measures of concurrent mental health, including depressive symptoms (Children's Depression Inventory-Short-Form; self-reported only), emotional distress, withdrawal, impulsive/hyperactive/inattentive behaviors, disruptive behaviors, prosocial behaviors, and peer relationship difficulties (victimization) (Social Behavior Questionnaire). Mental health symptoms were transformed into z-scores.nnRESULTS: Lifetime prevalence of NSSI (any method, at least once) was 28.2 %, with no sex differences between males (26.7 %) and females (29.4 %) (p=.403), with scratching being the most frequently reported method (17.2 %). Children reporting NSSI had significantly poorer mental health across indicators examined in both self- and teacher reports, although associations were generally smaller for teacher-reported symptoms. To illustrate, for 1 standard deviation increase in self-reported symptom scores, odds of NSSI were 2.31 times higher for depressive symptoms (95 % CI 1.82-2.92), and 1.70 times higher for peer victimization (95 % CI 1.46-1.99). Associations were stronger among children endorsing multiple NSSI methods compared to those reporting only one.nnCONCLUSION: NSSI (especially scratching) is present in late childhood and associated with worse mental health symptoms and peer problems.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41983935,

title = {Developmental Trajectories of Suicidality in Sexually Diverse and Heterosexual Adolescents: Findings From the Quebec Longitudinal Study of Child Development: Trajectoires développementales de suicidalité chez les adolescents hétérosexuels et de la diversité sexuelle : Résultats de l'Étude longitudinale sur le développement des enfants du Québec},

author = {Sasha MacNeil and Roxanne Sicotte and Camille Davisse-Paturet and Elise Chartrand and Em Alexander and Myriam Lecousy and Alain Girard and Massimiliano Orri and Nicholas Chadi and Isabelle Ouellet-Morin and Annie Pullen Sansfaçon and Srividya N Iyer and Natalie Castellanos-Ryan and Ian Colman and Robert-Paul Juster and Marie-Claude Geoffroy},

doi = {10.1177/07067437261442420},

issn = {1497-0015},

year  = {2026},

date = {2026-04-01},

journal = {Can J Psychiatry},

pages = {7067437261442420},

abstract = {IntroductionSexually diverse adolescents report higher suicidality (ideation and attempts) than their heterosexual peers, but information on the onset and course of suicidality from early adolescence to young adulthood among contemporary sexually diverse individuals remains limited. This study traces suicidality trajectories across this critical developmental period, comparing sexually diverse and heterosexual adolescents both overall and by sex assigned at birth.MethodsData was drawn from the Quebec Longitudinal Study of Child Development, an ongoing population-based prospective birth cohort. This study included 1,505 participants who self-reported their sexual attraction at ages 15-17 (2013-2015) and past-year suicidal ideation and attempts using 3-items at ages 13, 15, 17 and 23 (2011-2021) from which a suicidality severity score was derived.Results11.5% of the sample (n = 173, 60.5% female) reported sexually diverse attraction. Growth curve modelling tested the random effect of sexually diverse (vs. heterosexual) attraction on suicidality severity intercept, linear and quadratic latent growth factors. Age-specific contrasts in suicidality severity between sexually diverse and heterosexual adolescents were also examined. Compared to heterosexual adolescents, sexually diverse adolescents showed a steeper increase in suicidality severity from ages 13 to 17, and declining yet persisting disparities from ages 17 to 23. Although developmental trajectories differed across sexually diverse males and females, both experienced greater suicidality severity during adolescence compared with heterosexual peers.DiscussionOur findings point to a developmental trajectory in which sexually diverse adolescents, particularly females assigned at birth, experience elevated suicidality that persists into young adulthood. Targeted and timely interventions during this critical developmental period are essential for suicide prevention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41728805,

title = {Evaluating context effects on PHQ-8 somatic item scores among people with a chronic medical condition: a scleroderma patient-centred intervention network randomised experiment},

author = {Sophie Hu and Marie-Eve Carrier and Meira Golberg and Marie-Claude Geoffroy and Linda Kwakkenbos and Susan J Bartlett and Catherine Fortuné and Amy Gietzen and Karen Gottesman and Amanda Lawrie-Jones and Vanessa L Malcarne and Michelle Richard and Maureen Sauvé and Luc Mouthon and Andrea Benedetti and Brett D Thombs and },

doi = {10.1017/S204579602610047X},

issn = {2045-7979},

year  = {2026},

date = {2026-02-01},

journal = {Epidemiol Psychiatr Sci},

volume = {35},

pages = {e11},

abstract = {AIMS: Assessing depression symptoms in people with a chronic illness is challenging due to possible bias from overlapping somatic symptoms associated with both depression and chronic illnesses. Previous studies, however, have found that people with a chronic illness do not report more somatic symptoms on depression measures than people without a chronic illness with similar levels of mood and cognitive symptoms. The reason for this surprising finding is unknown. Our primary objective was to evaluate differences in mean sum scores of Patient Health Questionnaire-8 (PHQ-8) somatic symptom items (sleep disturbances, fatigue, appetite changes) in people with a chronic illness when the items were administered outside the context of a depression questionnaire versus as part of the PHQ-8. Secondary objectives were to evaluate individual somatic item scores. We hypothesised that people who completed somatic items outside of a depression assessment would have significantly higher scores than those who completed items as part of a depression assessment.nnMETHODS: We conducted a randomised controlled experiment within the Scleroderma Patient-centred Intervention Network (SPIN) Cohort, a multinational cohort of people with systemic sclerosis. SPIN Cohort participants were randomly allocated to complete the PHQ-8 with somatic items (sleep disturbances, fatigue, appetite changes) presented separately from psychological items and without any indication that they were part of a depression questionnaire (Reordered Items arm) or in standard format (Standard PHQ-8 arm). Participants were automatically randomised when they logged into the SPIN Cohort platform to complete routine research assessments. The primary outcome was the mean sum score of PHQ-8 somatic items. Secondary outcomes were the mean scores of individual somatic items. Differences were assessed using between-groups -tests.nnRESULTS: In total, 851 participants were included ( = 428 in Reordered Items arm,  = 423 in Standard PHQ-8 arm). Mean (SD) PHQ-8 score was 6.0 (5.3) for all participants. We found no statistically significant differences in PHQ-8 somatic item sum scores (0.05 points; 95% confidence interval [CI]: -0.29 to 0.38) or in mean scores for item 3 (sleep disturbances; 0.04 points; 95% CI: -0.09 to 0.19), item 4 (fatigue; 0.03 points; 95% CI: -0.11 to 0.16) and item 5 (appetite changes; -0.03 points; 95% CI: -0.15 to 0.10).nnCONCLUSIONS: We did not find evidence that responses to PHQ-8 somatic items were influenced by whether participants were aware they were responding to items about depression. This finding supports the validity of self-reported questionnaires for depression symptom assessment in people with chronic medical conditions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41175609,

title = {Sexual diversity, adolescent mental health, and adult cannabis use: Longitudinal associations through cannabis use motives},

author = {Kira London-Nadeau and Nina Pocuca and Charlie Rioux and Nicholas Chadi and Sylvana M Côté and Jean-Sébastien Fallu and Marie-Claude Geoffroy and Christophe Huynh and Robert-Paul Juster and Jean R Séguin and Natalie Castellanos-Ryan},

doi = {10.1016/j.addbeh.2025.108530},

issn = {1873-6327},

year  = {2026},

date = {2026-02-01},

journal = {Addict Behav},

volume = {173},

pages = {108530},

abstract = {PURPOSE: We examined prospective pathways between adolescent mental health and early adulthood cannabis use (CU) by sexual diversity, and the potential explanatory role of CU motives, accounting for confounders (demographics, CU frequency in adolescence).nnMETHODS: Participants from the Quebec Longitudinal Study of Child Development self-reported at 17 years on depressive symptoms, anxiety symptoms, and CU frequency, and at 23 years on CU motives, frequency and problems (471 participants total; 425 heterosexual; 46 sexually diverse).nnRESULTS: Depression - but not anxiety - symptoms at 17 years predicted CU problems at 23 years among sexually diverse participants only. This association was fully explained through coping motives, which were strongly predicted by depression symptoms in sexually diverse youth. While coping motives also predicted CU problems in heterosexual participants, coping motives were not predicted by mental health at 17 in this group. Depression symptoms at 17 also predicted social motives for CU among sexually diverse participants only, but this was not associated with CU frequency and problems. Finally, enhancement motives predicted CU problems at 23 years in both heterosexual and sexually diverse participants, but were not predicted by mental health at 17 years.nnCONCLUSIONS: Among sexually diverse youth, depression symptoms in adolescence may confer particular risk for later CU problems through CU for coping purposes. Increasing coping resources for sexually diverse adolescents experiencing psychological distress could help prevent later CU problems.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42416628,

title = {Young adult self-harm: The role of victimisation and polygenic risk in a population-based longitudinal study},

author = {Filip Marzecki and Isabelle Ouellet-Morin and Helena M S Zavos and Sylvana Côté and Richard E Tremblay and Jean-Philippe Gouin and Massimiliano Orri and Michel Boivin and Marie-Claude Geoffroy},

doi = {10.1002/jcv2.70061},

issn = {2692-9384},

year  = {2026},

date = {2026-01-01},

journal = {JCPP Adv},

pages = {e70061},

abstract = {BACKGROUND: Victimisation has been associated with self-harm (with or without suicidal intent), but little is known about this association during young adulthood-a distinct developmental period. Further, not all individuals who experience victimisation will later engage in self-harm, suggesting the influence of other factors. The present study examined whether perceived victimisation is associated with self-harm during young adulthood while adjusting for confounders such as peer victimisation and mental health difficulties in adolescence. Additionally, we investigated whether genetic susceptibility for mental health difficulties moderates this association.nnMETHODS: Participants were from the Quebec Longitudinal Study of Child Development (1998-2023); a population-based birth cohort from the Canadian province of Quebec, with victimisation and self-harm measures in young adulthood (sample 1;  = 1235), and who provided blood samples and had been genotyped (sample 2;  = 552). At 20 years old, they were asked how often they had experienced forms of victimisations in the past 12 months (e.g., insulted you, put you down in front of others) without specifying the perpetrator. At 20-25 years old, participants reported self-harm. Polygenic scores (PGSs) for depression, attention deficit hyperactivity disorder (ADHD) and suicide attempt were calculated.nnRESULTS: Overall, 17.2% (sample 1) participants reported self-harm at age 20-25 years. Victimisation was associated with self-harm (OR = 1.66, 95% CI = 1.45, 1.89, for each standard deviation increase in victimisation), even after adjusting for confounders, for example, victimisation and mental health in adolescence (OR = 1.53, 95% CI = 1.26, 1.86). In sample 2, PGSs for depression and suicide attempt (not ADHD) were associated with self-harm as well as victimisation in young adulthood, and none moderated the association between victimisation and self-harm.nnCONCLUSION: Regardless of genetic susceptibility indexed by PGSs, young adult exposed to victimisation are at higher risk of self-harm. Continuing efforts to prevent victimisation beyond childhood/adolescence and into young adulthood may contribute to reducing self-harm risk.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41483051,

title = {Development of Substance Use Problems: The Role of Adolescent Cannabis Age of Onset, Frequency of Use and Childhood Risk Factors},

author = {Jad Hamaoui and Erinn Acland and Frank Vitaro and Jean-Sébastien Fallu and Sophie Parent and Cléa Simard and Michel Boivin and Sylvana Côté and Marie-Claude Geoffroy and Jean R Séguin and Natalie Castellanos-Ryan},

doi = {10.1007/s10802-025-01404-z},

issn = {2730-7174},

year  = {2026},

date = {2026-01-01},

journal = {Res Child Adolesc Psychopathol},

volume = {54},

number = {1},

pages = {1},

abstract = {Substance use (SU) problems are critical public health concerns. This study investigated how childhood risk factors and cannabis age of onset (CAO) in adolescence predict later SU problems, using data from the two cohorts of the Quebec Longitudinal Study of Child Development (N = 306; 57% female; N = 1489; 54% female), followed from birth to age 23. A direct association between early CAO and increased cannabis use problems was found in males (cohort 1: β = -0.47; cohort 2: β = -0.22), but not in females. In both sexes, CAO was indirectly associated with later cannabis use problems via increased adolescent cannabis use frequency (cohort 1: ab = -0.41; cohort 2: ab = -0.35). Similar indirect associations were observed between CAO and other SU problems (including tobacco and alcohol), via adolescent cannabis use frequency (cohort 1: ab = -2.63). Parental cannabis use, adverse childhood experiences, and childhood externalizing behaviors (i.e., physical aggression and ADHD symptoms) were associated with early CAO and subsequent CU problems. These findings support developmental models linking early risk exposures to maladaptive substance use pathways and underscore the importance of prevention strategies targeting early cannabis initiation and modifiable early-life risk factors to reduce long-term SU-related problems.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41556631,

title = {Differential Item Functioning on the Patient Health Questionnaire 8 by Disease Subtype, Language, Sex, and Age Among People With Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study},

author = {Sophie Hu and Marie-Eve Carrier and Marie-Claude Geoffroy and Meira Golberg and Linda Kwakkenbos and Susan J Bartlett and Catherine Fortuné and Amy Gietzen and Karen Gottesman and Geneviève Guillot and Laura K Hummers and Amanda Lawrie-Jones and Vanessa L Malcarne and Michelle Richard and Maureen Sauvé and Luc Mouthon and Andrea Benedetti and Brett D Thombs and },

doi = {10.1002/acr.70041},

issn = {2151-4658},

year  = {2026},

date = {2026-01-01},

journal = {Arthritis Care Res (Hoboken)},

abstract = {OBJECTIVE: Somatic items used in depression assessments can potentially overlap with symptoms related to physical illness, including systemic sclerosis (SSc). No studies have looked at whether somatic depression items may be influenced by diffuse versus limited SSc disease subtypes, which are associated with varying degrees of symptom presentation. The objective of this study was to evaluate differential item functioning (DIF) in items of the 8-item Patient Health Questionnaire (PHQ-8) across SSc subtypes. We also assessed the PHQ-8 for DIF across language (English and French), sex, and age.nnMETHODS: Participants enrolled in the Scleroderma Patient-Centered Intervention Network Cohort who completed the PHQ-8 at enrollment between April 2014 and October 2020 were included. Confirmatory factor analysis (CFA) was used to evaluate the unidimensional structure of the PHQ-8, and DIF analyses based on SSc subtype, language, sex, and age were conducted using Multiple Indicators Multiple Causes models.nnRESULTS: In total, 2,191 participants were included. CFA with several covarying error terms supported a one-factor structure for the PHQ-8 (Tucker-Lewis Index = 0.99, Comparative Fit Index = 0.98, Root Mean Square Error of Approximation = 0.08). We did not identify statistically significant DIF based on SSc subtype. Statistically significant DIF was found in one item for language, one item for sex, and two items for age. However, the effect of DIF on overall PHQ-8 scores was negligeable in all cases.nnCONCLUSION: We did not find evidence that the PHQ-8 performs differently across SSc subtypes, language of administration, sex, and age groups.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42416671,

title = {Decision-making and risk-taking as predictors of health risk behaviors in the Millennium Cohort Study},

author = {Nicole G Hammond and Georgia Condran and Elise E DeVito and Marie-Claude Geoffroy and Ian Colman},

doi = {10.1002/jcv2.70071},

issn = {2692-9384},

year  = {2025},

date = {2025-12-01},

journal = {JCPP Adv},

pages = {e70071},

abstract = {BACKGROUND: Facets of decision-making and risk-taking are implicated in adolescent health risk behaviors; however, whether they may lead to adolescent engagement in substance use, gambling, and self-harm is unknown.nnMETHODS: We used the Millennium Cohort Study to test whether a task-based measure of decision-making and risk-taking predicts engagement in adolescent health risk behaviors. Participants were born in the United Kingdom (2000-2002) and surveyed in-home at ages 14 ( = 10,531) and 17 ( = 8417). A computerized task-based measure of decision-making and risk-taking for reward (Cambridge Gambling Task) measured impulsivity, quality of decision-making, risk adjustment, and risk-taking (exposures) at age 14. Several health risk behaviors (outcomes) were self-reported at 14/17 years: cigarette use, electronic cigarette/vaping use, drinking, cannabis use, other illegal drug use (e.g., ecstasy), gambling, and self-harm. We conducted adjusted multinomial and logistic regression models.nnRESULTS: Computerized task-based measures of greater impulsivity and risk-taking were most consistently associated with self-reported health risk behaviors at 14 and 17 years. Better quality of decision-making and risk adjustment were inconsistently associated with health outcomes at age 14; however, better risk adjustment was related to a reduced likelihood of all levels of cigarette and e-cigarette/vaping use (e.g., occasionally/regularly) when compared to nonusers. At age 14, risk-taking was associated with every self-reported health risk behavior (e.g., substance use, gambling) except for self-harm. In prospective models, relationships were attenuated, but risk-taking predicted new onset engagement in all forms of substance use except alcohol consumption and self-harm. Risk-taking was most strongly associated with other drug use (age 14: odds ratio (OR) = 11.26, 95% CI: 1.48, 86.01) and predictive of former vaping use (age 17: OR = 4.10, 95% CI: 1.43, 11.76).nnCONCLUSION: Risky betting on a computerized risk-taking task appears highly indicative of substance use and recent gambling at age 14 and predictive of new onset substance use and gambling 3 years later (age 17) for both sexes, but not self-harm.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41111315,

title = {Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression},

author = {Isabelle Ouellet-Morin and Marie-Claude Geoffroy and Pascal Louis and Ivan Voronin and Geneviève Morneau-Vaillancourt and Rachel Langevin and Delphine Collin-Vézina and Charles-Edouard Giguère and Mélanie Bouliane and Amélie Petitclerc and Mara Brendgen and Frank Vitaro and Richard Ernest Tremblay and Michel Boivin},

doi = {10.1017/S0954579425100801},

issn = {1469-2198},

year  = {2025},

date = {2025-10-01},

journal = {Dev Psychopathol},

pages = {1--14},

abstract = {BACKGROUND: Childhood maltreatment is a robust predictor of aggression. Research indicates that both maltreatment experiences and aggression are moderately heritable. It has been hypothesized that gene-environment correlation may be at play, whereby genetic predispositions to aggression in parents and children may be confounded with family environments conducive to its expression. Building on this framework, we tested whether maltreatment mediates the association between a polygenic score for aggression (PGS) and school-age aggression, and whether this varied for reactive and proactive aggression.nnMETHODS: The sample comprised 721 participants (44.9% males; 99.0% White) with prospective assessments of maltreatment from 5 months to 12 years (10 assessments;1998-2010), and teachers-reported aggression from ages 6 to 13 (6 assessments; 2004-2011). The PGS was derived using a Bayesian estimation method (PRS-CS).nnRESULTS: PGS was associated with most aggression measures across specific ages and trajectories. Maltreatment experiences partially mediated the association between PGS and the Childhood-Limited trajectory of reactive - but not proactive - aggression.nnCONCLUSION: Children with higher genetic propensities for aggression were more likely to experience maltreatment, which partly explained the association between PGS and a Childhood-Limited trajectory of reactive aggression during elementary school. This finding reinforces the possibility of confounding influences between genetic liability for aggression and maltreatment experiences.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41038792,

title = {Associations of childhood irritability and parenting profiles with youth suicide attempt: a longitudinal person-centered approach},

author = {Cassandra Zephirin and Marie-Claude Geoffroy and Eszter Szekely and Léa C Perret and Michel Boivin and Richard E Tremblay and Sylvana M Côté and Massimiliano Orri},

doi = {10.1017/S003329172510192X},

issn = {1469-8978},

year  = {2025},

date = {2025-10-01},

journal = {Psychol Med},

volume = {55},

pages = {e292},

abstract = {BACKGROUND: Childhood irritability and harsh parenting are associated with youth suicide attempts. Parents' harsh reactions have been associated with children's irritable behavior. While studies have shown individual associations of irritability and parenting behaviors with suicide risk, few have considered these factors jointly. We aimed to identify profiles of children based on irritability and parenting during childhood and examine their associations with youth suicide attempt.nnMETHODS: Participants ( = 1626) were from the Québec Longitudinal Study of Child Development. Mothers reported on childhood irritability, harsh parenting, and positive parenting between ages 3.5 and 8; youth self-reported suicide attempt between ages 13 and 23.nnRESULTS: We identified four profiles based on the joint development of irritability and parenting during childhood: (1) low irritability, low harsh parenting, and high positive parenting (30.3%); (2) moderate irritability, moderate harsh parenting, and high positive parenting (28.4%); (3) moderate irritability, moderate harsh parenting, and low positive parenting (26.6%); and (4) high irritability, high harsh parenting, and low positive parenting (14.8%). In logistic regression analyses, only children in the high irritability, high harsh parenting, and low positive parenting profile had higher odds of attempting suicide (OR = 2.51; 95% CI = 1.55-4.09) compared to those in the low irritability, low harsh parenting, and high positive parenting profile. This association remained significant (OR = 1.80; 95% CI = 1.03-3.15) in models adjusting for covariates.nnCONCLUSION: Children with chronically high irritability were also those experiencing the harshest parenting and the least positive parenting, as well as those most at risk of suicide attempt. Targeting both child and parental behavior may maximize suicide prevention efforts among children with high irritability.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41148134,

title = {Health Service Use Among Young Adults With a History of Adolescent Cannabis Use},

author = {Pablo Martínez and Nicholas Chadi and Natalie Castellanos-Ryan and Francis Vergunst and Marc Dorais and Jean R Séguin and Frank Vitaro and Caroline Temcheff and Richard E Tremblay and Michel Boivin and Sylvana M Côté and Marie-Claude Geoffroy and Massimiliano Orri},

doi = {10.1001/jamanetworkopen.2025.39977},

issn = {2574-3805},

year  = {2025},

date = {2025-10-01},

journal = {JAMA Netw Open},

volume = {8},

number = {10},

pages = {e2539977},

abstract = {IMPORTANCE: Adolescent cannabis use is a substantial public health concern given its associations with adverse mental and physical health outcomes. Understanding how distinct use patterns are associated with medical care utilization in young adulthood is critical for prevention.nnOBJECTIVE: To examine the association between patterns of adolescent cannabis use and medical care utilization for mental and physical health conditions in young adulthood.nnDESIGN, SETTING, AND PARTICIPANTS: This population-based birth cohort study linked to population-wide administrative medical care databases was conducted in the Province of Québec, Canada. Participants included individuals recruited for the Québec Longitudinal Study of Child Development, followed up from birth (1997-1998) to 23 years of age (2021). Data were analyzed November 2023 to February 2025.nnEXPOSURE: Self-reported past 12-month cannabis use at ages 12, 13, 15, and 17 years.nnMAIN OUTCOMES AND MEASURES: Medical care utilization for any mental disorder (including common mental disorders and substance-related disorders), suicide-related behaviors, and any physical health condition (including respiratory diseases, injuries and poisoning, and other physical diseases) between ages 18 and 23 years. Analyses were adjusted for 32 individual, family, and community-level confounders measured from birth to younger than 12 years of age using overlap weights.nnRESULTS: Data for 1591 individuals (818 female [51.4%]; mean [SD] age at first exposure assessment, 12.1 [0.3] years) were analyzed. Three distinct adolescent cannabis use patterns were identified via group-based trajectory modeling: nonuse (948 [59.6%]), late-onset use (318 [20.0%], initiating after age 15 years), and early-onset and frequent use (325 [20.4%], initiating before age 15 years). In fully adjusted analyses, individuals with early-onset and frequent use had significantly higher odds of medical care utilization for any mental disorder (odds ratio [OR], 1.51 [95% CI, 1.10-2.08]), common mental disorders (OR, 1.57 [95% CI, 1.12-2.21]), any physical health condition (OR, 1.86 [95% CI, 1.30-2.67]), injuries and poisoning (OR, 1.41 [1.05-1.89]), and other physical diseases (OR, 1.47 [95% CI, 1.08-1.98]), compared with individuals with no use. Individuals with late-onset use did not differ significantly from those with nonuse for mental health outcomes (OR, 1.13 [95% CI, 0.80-1.58]) but had higher odds of medical care utilization for any physical health condition (OR, 1.63 [95% CI, 1.16-2.28]).nnCONCLUSIONS AND RELEVANCE: Findings of this birth cohort study indicated that early-onset and frequent cannabis use was associated with greater medical care utilization for both mental and physical health conditions in young adulthood. These findings support the relevance of delaying initiation and reducing intensity of cannabis use during adolescence.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40971205,

title = {Outcome Evaluation of a Multimodal Suicide Prevention Program Designed Through International Collaboration: Protocol for a Controlled Interrupted Time Series Study},

author = {Jean-Daniel Carrier and Marie-Claude Geoffroy and Michel Walter and Katia Dumont and Massimiliano Orri and Sofian Berrouiguet and Christophe Lemey and Monique Séguin},

doi = {10.2196/66976},

issn = {1929-0748},

year  = {2025},

date = {2025-09-01},

journal = {JMIR Res Protoc},

volume = {14},

pages = {e66976},

abstract = {BACKGROUND: The Coopération Québec-France contre la Dépression et l'Isolement (CQFD-I) initiative represents a collaborative effort between Outaouais, a region in Quebec, and Brest, a metropolitan area in France, to reduce suicide through a multimodal approach. CQFD-I integrates 5 key strategies: a web portal on depression, education of primary care physicians on depression, training for mental health professionals in suicide risk assessment and management, and standardized postcrisis outreach and outpatient monitoring protocols.nnOBJECTIVE: This paper aims to evaluate the effectiveness of CQFD-I in reducing outcomes related to suicidal behavior, namely suicide mortality, hospitalizations due to suicide attempts, and emergency room visits for suicide attempts, across the implementation sites compared to control areas.nnMETHODS: The evaluation will use a controlled, segmented interrupted time series design, spanning 3 distinct phases: preimplementation (2015 to 2020), implementation (2020 to 2022), and postimplementation (2022 to 2024) phases. The outcomes will be (1) suicide mortality, (2) hospitalizations for suicide attempts, and (3) emergency room visits for suicide attempts. Datasets covering September 2015 to August 2024 will be provided by public health organizations in both jurisdictions, that is, the Institut national de la santé publique du Québec and Santé publique France. In Quebec, control sites will consist of the 14 other health regions with a population of at least 50,000, while in France, control sites will include the 18 metropolitan areas with a status comparable to that of Brest Métropole. The analysis will focus on age- and sex-adjusted monthly rates of the specified outcomes, with an emphasis on changes across the study phases to assess the putative effectiveness of the CQFD-I intervention. We hypothesize that each study outcome will decrease by 20% at implementation sites compared to control sites between the preimplementation and postimplementation phases.nnRESULTS: This project is funded by the Ministère de la Santé et des Services Sociaux du Québec, with access to data and expertise representing in-kind contributions from Santé publique France and Institut national de la santé publique du Québec. Data collection, led by the first author, will take place in September 2027 to allow for the delay required to confirm suicide deaths in official registers, with analysis planned between 2027 and 2028.nnCONCLUSIONS: To our knowledge, this study will be the first to document the outcomes of a multimodal suicide prevention program targeting geographically defined areas within 2 countries, not limited to the European Union.nnINTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/66976.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40382867,

title = {Social and mental health pathways to institutional trust: A cohort study},

author = {Vincent Paquin and Diana Miconi and Samantha Aversa and Janique Johnson-Lafleur and Sylvana Côté and Marie-Claude Geoffroy and Sinan Gülöksüz},

doi = {10.1016/j.socscimed.2025.118199},

issn = {1873-5347},

year  = {2025},

date = {2025-08-01},

journal = {Soc Sci Med},

volume = {379},

pages = {118199},

abstract = {OBJECTIVE: Trust in institutions such as the government is lower in the context of mental health problems and socio-economic disadvantage. However, the roles of structural inequality, interpersonal factors, and mental health on institutional trust remain unclear. This study aimed to examine the associations of social and mental health factors, from early life to adulthood, with institutional trust.nnMETHOD: Participants (n = 1347; 57.2 % female) were from the population-based Québec Longitudinal Study of Child Development (1997-2021). Trust in 13 institutions was self-reported at age 23. Predictors were 20 social and mental health factors during early life, adolescence, and adulthood. Associations were examined with linear regressions corrected for false discovery rate. Pathways were explored using the temporal Peter-Clark algorithm.nnRESULTS: Early-life factors associated with lower levels of trust were male sex, racialized minority status, low household income, and maternal history of depression and antisocial behaviors. After adjusting for early-life factors, adolescence factors associated with lower levels of trust were internalizing and externalizing problems, bullying exposure, and school difficulties. Independently of early-life or adolescence factors, adulthood factors associated with lower levels of trust were perceived stress, psychotic experiences, suicidal ideas, and seeking professional help, whereas greater social connectedness was associated with greater trust. Temporal Peter-Clark analyses identified social connectedness and psychotic experiences as potential proximal determinants of institutional trust.nnCONCLUSION: This study identified factors related to structural inequality, interpersonal relationships, and mental health over development that were associated with institutional trust. Interventions aimed at promoting social connectedness and equity may improve institutional trust and wellbeing.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40645654,

title = {Association of hyperactivity-impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study},

author = {Michel Spodenkiewicz and Ayla Inja and Samuele Cortese and Cedric Galera and Isabelle Ouellet-Morin and Sylvana M Côté and Michel Boivin and Frank Vitaro and Mara Brendgen and Ginette Dionne and Johanne Renaud and Richard E Tremblay and Gustavo Turecki and Marie-Claude Geoffroy and Massimilano Orri},

doi = {10.1136/bmjment-2025-301725},

issn = {2755-9734},

year  = {2025},

date = {2025-07-01},

journal = {BMJ Ment Health},

volume = {28},

number = {1},

abstract = {BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptomatology in childhood is associated with a high risk of suicide attempt later in life. However, symptom presentation in ADHD is heterogeneous, and little is known about how suicide risk varies according to different profiles of ADHD symptoms and sex.nnOBJECTIVE: The aim was to investigate the longitudinal associations between childhood profiles of ADHD symptoms (ie, hyperactivity-impulsivity and inattention) and youth suicide attempt in males and females, separately.nnMETHODS: This population-based cohort study used data from three longitudinal cohorts: the Quebec Longitudinal Study of Child Development (QLSCD), the Quebec Longitudinal Study of Kindergarten Children (QLSKC) and the Quebec Newborn Twin Study (QNTS) for a total of 4399 participants (1490 from the QLSCD, 2134 from the QLSKC and 775 from the QNTS; 50% females) followed up from ages 6-23 years. Symptoms of hyperactivity-impulsivity and inattention were assessed by teachers five times from ages 6-12 years. Suicide attempt in adolescence and young adulthood (by age 23) was self-reported. Multitrajectory modelling was used to identify profiles of ADHD symptoms, and regression analysis was used to test their association with suicide attempt, adjusting for childhood socioeconomic and clinical characteristics.nnFINDINGS: We identified four ADHD symptom profiles with distinct associations with suicide attempt for males and females. Compared with those with persistently low symptoms, females with persistently high inattention and hyperactivity-impulsivity (OR: 2.54, CI 1.39 to 4.63) or high inattention and low hyperactivity-impulsivity (OR: 1.81, CI 1.21 to 2.70) were at higher risk of suicide attempt, while, among males, only those with decreasing hyperactivity-impulsivity and inattention over time (OR: 2.23, CI 1.20 to 4.13) were at higher risk of suicide attempt.nnCONCLUSIONS: Risk of suicide attempt in children with ADHD symptoms varies according to both symptom profile and sex, the highest risk being for females with high inattention symptoms (with or without hyperactivity), and males with decreasing symptoms.nnCLINICAL IMPLICATIONS: Taking into account differences in both sex and ADHD symptoms profile may be relevant to more accurately identify and manage suicide risk in individuals with high ADHD symptoms, though caution is needed when generalising our population-based findings to clinical populations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40601344,

title = {Mental Health Antecedents and Correlates of 2 Distinct Developmental Pathways to Suicidal Ideation},

author = {Marie-Claude Geoffroy and Sasha MacNeil and Vincent Paquin and Ayla Inja and Alain Girard and Élise Chartrand and Natalie Castellanos-Ryan and Charles-Édouard Notredame and Ian Colman and Massimiliano Orri and Gustavo Turecki and Sylvana Côté},

doi = {10.1001/jamapsychiatry.2025.1273},

issn = {2168-6238},

year  = {2025},

date = {2025-07-01},

journal = {JAMA Psychiatry},

abstract = {IMPORTANCE: Suicidal ideation is increasingly common in youth. Trajectories and associated mental health symptoms across development remain poorly understood.nnOBJECTIVE: To describe trajectories of suicidal ideation from early adolescence to young adulthood and identify preceding and co-occurring mental health symptoms to inform optimal prevention.nnDESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from a contemporary, longitudinal cohort study, the Québec Longitudinal Study of Child Development (QLSCD), including reports from participants, parents, and teachers. The QLSCD is a population-based birth cohort study of 2120 singletons born between 1997 and 1998 in Québec, Canada, and followed up to age 25 years (2023). Data were analyzed from September 2024 to February 2025.nnMAIN OUTCOMES AND MEASURES: Serious suicidal ideation in the past 12 months was assessed by a question to participants at ages 13, 15, 17, 20, 23, and 25 years.nnEXPOSURES: Mental health symptoms (eg, internalizing, externalizing) as reported by parents, teachers, and self-reports on validated questionnaires and standardized across 5 developmental periods: preschool (3-5 years), childhood (6-12 years), early adolescence (13 years), mid-late adolescence (15-17 years), and young adulthood (20-25 years).nnRESULTS: A total of 1635 participants (845 female [51.7%]; participant number is weighted to account for selective attrition) provided answers on suicidal ideation, with survey weights applied. A total of 3 trajectories were identified: minimal/no ideation (1433 [87.6%]), onset in early adolescence (117 [7.1%]), and onset in young adulthood (86 [5.2%]). Relative to minimal/no ideation, onset in early adolescence was associated with elevated symptoms across nearly all mental health indicators from childhood through adulthood. This included both internalizing (eg, childhood depressive symptoms: risk ratio [RR], 1.75; 95% CI, 1.45-2.05) and externalizing (eg, childhood disruptive symptoms: RR, 1.60; 95% CI, 1.29-1.91) symptoms and maternal antisocial symptoms (RR, 1.39; 95% CI, 1.11-1.66). In contrast, onset of suicidal ideation in young adulthood was associated with internalizing symptoms (eg, mid-late adolescence depressive symptoms: RR, 1.84; 95% CI, 1.28-2.39) emerging in adolescence and worsening mental distress in young adulthood.nnCONCLUSIONS AND RELEVANCE: Results of this cohort study revealed 2 pathways to suicidal ideation: onset in early adolescence, with persistent childhood internalizing/externalizing symptoms, and onset in young adulthood linked to internalizing symptoms emerging in adolescence without prior distress. Findings suggest timely addressing of mental health symptoms and developmental stage-specific prevention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40590827,

title = {Suicide Ideation During Adolescence and Predictors for Its Trajectories: A 6-Year Follow-Up Study in Korea},

author = {Tianna Loose and Léa Perret and Minjae Choi and Marie-Claude Geoffroy and Duckyoung Chon and Jihee Kim and Myung Ki},

doi = {10.1016/j.jadohealth.2025.05.014},

issn = {1879-1972},

year  = {2025},

date = {2025-07-01},

journal = {J Adolesc Health},

abstract = {PURPOSE: Suicide ideation experienced by adolescents may persist over time but is also subject to change. With due consideration of the changing nature of suicide ideation in adolescents, we aimed to identify the trajectories of suicide ideation and the protective and risk factors associated with each trajectory.nnMETHODS: This study used a 6-year follow-up cohort of adolescents (n = 2,205) who were aged 13 years, first-year middle school students at baseline, from the Korean Children and Youth Panel Study. We conducted growth mixture modeling to characterize trajectories of suicide ideation, which were measured at four time points over the middle and high school periods. Using multinomial logistic regression, we analyzed a wide range of factors in relation to suicide ideation trajectories with adjustment for demographic and behavioral characteristics.nnRESULTS: Suicide ideation reached a peak in the third year of middle school (15.7% at age 15). Three different trajectories (low, transient, and persistent) were identified. Depressive symptoms, maltreatment, and low self-esteem were associated with greater risk of both transient and persistent suicide ideation trajectories, but with a higher magnitude of association for the persistent trajectory. When transient and persistent trajectories were compared, depressive symptoms (odds ratio [OR] = 1.45, 95% confidence interval [CI] = 1.08-1.94), cell phone dependency (OR = 1.20, 95% CI = 0.96-1.50), and self-esteem (OR = 0.79, 95% CI = 0.61-1.02) were differentiated two trajectories.nnDISCUSSION: Similar protective and risk factors were associated with both transient and persistent suicide ideation but with stronger associations for persistent trajectories. Self-esteem, maltreatment, and depression may act as a broad-spectrum intervention point to target both transient and persistent suicide ideation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40518731,

title = {Aggression, Suicidality, and Emotion Profiles in Youth: Links to Early Life Adversity},

author = {Erinn Acland and Nina Pocuca and Sophie Chaput-Langlois and Jad Hamaoui and Julie Girard-Lapointe and Sylvana Côté and Natalie Castellanos-Ryan and Marie-Claude Geoffroy},

doi = {10.1002/ab.70038},

issn = {1098-2337},

year  = {2025},

date = {2025-07-01},

journal = {Aggress Behav},

volume = {51},

number = {4},

pages = {e70038},

abstract = {Suicidality and physical aggression are leading, related youth public health concerns. Yet, whether adolescents who harm themselves, others, or both differ emotionally and etiologically remains unclear. To address this, adolescents from a prospective population-based birth cohort reported their suicidality, physical aggression, depression/anxiety symptoms, anger, and callousness (N = 1637). Distinct latent harm-emotion profiles were identified, which were linked to perinatal and childhood experiences. A six-profile solution was retained: Low harm (79.5%), moderate suicidality (6.5%), high suicidality (2%), high aggression (2.5%), moderate aggression (8.5%), and high suicidality and aggression (dual harm; 1%). Elevated harm profiles were compared to the low-harm group. Moderate/high suicidality profiles showed slight elevations in physical aggression. All elevated harm profiles expressed higher negative emotionality. Dual harm and aggression groups reported higher callousness, while suicidality groups reported lower callousness. Aggression profiles were 75% male, suicidality profiles were 21% male, while the low and dual-harm profiles were more similarly mixed sex (47% vs. 63% male, respectively). Low-harm youth experienced more positive childhood parenting. The dual harm and high aggression groups had more deviant childhood best friends, while the dual harm and moderate aggression groups had lower early life household income. The moderate suicidality group had fathers with higher depressive symptoms during infancy and childhood. Thus, one in five youth showed relatively elevated suicidality and/or physical aggression; of which, 95% tended to have a primary target (themselves or others). Early life economic, parental, and peer support may be key for preventing suicidal and aggressive outcomes in adolescence.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39901502,

title = {The Relationship Between Family Dynamics and Help-Seeking and Disclosure of Adolescent Self-Harm and Suicidality: A Population-Representative Study: Relation entre dynamique familiale et recherche d'aide, et dévoilement des actes d'automutilation et de la suicidalité chez les adolescents : étude représentative de la population},

author = {Nicole G Hammond and Christopher Gravel and Mark A Ferro and Hannah Landry and Marie-Claude Geoffroy and Nicole Racine and Ian Colman},

doi = {10.1177/07067437251315526},

issn = {1497-0015},

year  = {2025},

date = {2025-05-01},

journal = {Can J Psychiatry},

volume = {70},

number = {5},

pages = {404--413},

abstract = {BackgroundFew studies have explored the potential for family dynamics to hinder or promote help-seeking and disclosure behaviours among adolescents who self-harm or experience suicidality. We sought to examine whether family dynamics may influence self-harm-related disclosure to parents or other family members and online help-seeking.MethodsWe identified youths, 14-17 years, in the 2014 Ontario Child Health Study (OCHS) who self-reported past-year suicidal ideation (with or without a suicide plan or past suicide attempt[s]) and/or non-suicidal self-harm. The OCHS is a provincially representative, cross-sectional survey. The person most knowledgeable about the adolescent, usually the mother, reported family dynamics: family dysfunction and positive and negative parenting practices. We used logistic regression to generate adjusted odds ratios.ResultsA total of 359 adolescents positively endorsed past-year suicidal ideation and/or non-suicidal self-harm. Disclosure and help-seeking were common (≥67.3% and ≥25.6%, respectively). Adolescents experiencing suicidal ideation and greater family dysfunction were more likely to share their suicidal thoughts with non-family compared to not telling anyone (OR = 1.09, 95% CI: 1.01 to 1.18) and were less likely to tell their parents or other family members about their suicidal thoughts when compared to non-family such as teachers, partners, or friends (OR = 0.82, 95% CI: 0.71 to 0.94). Positive parenting was not associated with any form of disclosure or online help-seeking for non-suicidal self-harm or suicidal ideation. As adolescent exposure to negative parenting increased, so did the likelihood that they would seek help online for their suicidal thoughts (OR = 1.22, 95% CI: 1.08 to 1.37). Sensitivity analyses replicated or were very similar to findings from the main models.ConclusionWe found that negative family dynamics were related to reduced sharing of suicidal thoughts with parents or other family members and greater online help-seeking. Our findings suggest that the importance of negative family dynamics to disclosure and support-seeking for adolescent suicidality may be under-recognized.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}