@article{pmid32017089,

title = {Cybervictimization in adolescence and its association with subsequent suicidal ideation/attempt beyond face-to-face victimization: a longitudinal population-based study},

author = {Lea C Perret and Massimiliano Orri and Michel Boivin and Isabelle Ouellet-Morin and Anne-Sophie Denault and Sylvana M Côté and Richard E Tremblay and Johanne Renaud and Gustavo Turecki and Marie-Claude Geoffroy},

doi = {10.1111/jcpp.13158},

issn = {1469-7610},

year  = {2020},

date = {2020-08-01},

journal = {J Child Psychol Psychiatry},

volume = {61},

number = {8},

pages = {866--874},

abstract = {BACKGROUND: Cross-sectional associations have been documented between cybervictimization and suicidal risk; however, prospective associations remain unclear.nnMETHODS: Participants were members of the Quebec Longitudinal Study of Child Development (QLSCD), a prospective birth cohort of 2,120 individuals followed from birth (1997/98) to age 17 years (2014/15). Cybervictimization and face-to-face victimization experienced since the beginning of the school year, as well as serious suicidal ideation and/or suicide attempt were self-reported at ages 13, 15 and 17 years.nnRESULTS: In cross-sectional analyses at 13, 15 and 17 years, adolescents cybervictimized at least once had, respectively, 2.3 (95% CI = 1.64-3.19), 4.2 (95% CI = 3.27-5.41) and 3.5 (95% CI = 2.57-4.66) higher odds of suicidal ideation/attempt after adjusting for confounders including face-to-face victimization, prior mental health symptoms and family hardship. Sensitivity analyses suggested that cybervictimization only and both cyber- and face-to-face victimization were associated with a higher risk of suicidal ideation/attempt compared to face-to-face victimization only and no victimization; however, analyses were based on small n. In prospective analyses, cybervictimization was not associated with suicidal ideation/attempt 2 years later after accounting for baseline suicidal ideation/attempt and other confounders. In contrast, face-to-face victimization was associated with suicidal ideation/attempt 2 years later in the fully adjusted model, including cybervictimization.nnCONCLUSIONS: The cross-sectional association between cybervictimization and suicidal ideation/attempt is independent from face-to-face victimization. The absence of a prospective association suggested short-term effects of cybervictimization on suicidal ideation/attempt.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32513840,

title = {Mental Health Problems and Risk of Suicidal Ideation and Attempts in Adolescents},

author = {Massimiliano Orri and Sara Scardera and Léa C Perret and Despina Bolanis and Caroline Temcheff and Jean R Séguin and Michel Boivin and Gustavo Turecki and Richard E Tremblay and Sylvana M Côté and Marie-Claude Geoffroy},

doi = {10.1542/peds.2019-3823},

issn = {1098-4275},

year  = {2020},

date = {2020-07-01},

journal = {Pediatrics},

volume = {146},

number = {1},

abstract = {BACKGROUND: Obtaining recent estimates of the prevalence of suicide-related outcomes across adolescence and its associated mental health problems (MHPs) is important for clinical practice. We estimated the prevalence of suicide-related outcomes at ages 13, 15, 17, and 20 years (2011-2018) in a contemporary population-based cohort and documented associations with MHPs throughout adolescence.nnMETHODS: Data came from 1618 participants in the Québec Longitudinal Study of Child Development. Internalizing (depression and anxiety) and externalizing (oppositional/defiance, conduct issues, and attention deficit and/or hyperactivity) MHPs were assessed with validated questionnaires. Outcomes were self-reported past-year passive and serious suicidal ideation and suicide attempt.nnRESULTS: Lifetime prevalence of passive suicidal ideation (13-17 years old), serious suicidal ideation, and suicide attempt (13-20 years old) were 22.2%, 9.8%, and 6.7%, respectively. Prevalence was twice as high for females as for males. Overall, rates of passive (15-17 years old; 11.8%-18.4%) and serious ideation (13-20 years old; 3.3%-9.5%) increased over time but were stable for attempt (13-20 years old; 3.5%-3.8%). In univariable analyses, all MHPs were associated with suicide-related outcomes at all ages (risk rate ratio range: 2.57-3.10 [passive ideation] and 2.10-4.36 [suicide attempt]), and associations were similar for male and female participants (sex interaction  > .05). Magnitude of associations were generally stronger for more severe suicide-related outcomes (passive ideation < serious ideation < attempt). In multivariable analyses, internalizing problems were associated with suicidal ideation, whereas both depressive and conduct symptoms were associated with attempt.nnCONCLUSIONS: Suicidal ideation and attempt were common, especially for females and youth presenting with depressive and conduct problem symptoms. Clinicians should systematically assess suicidal risk in teenagers, especially in those presenting with MHPs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31782164,

title = {Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence},

author = {Massimiliano Orri and Marie-Claude Geoffroy and Gustavo Turecki and Bei Feng and Mara Brendgen and Frank Vitaro and Ginette Dionne and Stephane Paquin and Cedric Galera and Johanne Renaud and Richard E Tremblay and Sylvana M Côté and Michel Boivin},

doi = {10.1111/jcpp.13163},

issn = {1469-7610},

year  = {2020},

date = {2020-06-01},

journal = {J Child Psychol Psychiatry},

volume = {61},

number = {6},

pages = {711--720},

abstract = {BACKGROUND: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood.nnMETHODS: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsive-aggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components.nnRESULTS: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027.nnCONCLUSIONS: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32238448,

title = {Early Childhood Factors Associated With Peer Victimization Trajectories From 6 to 17 Years of Age},

author = {Sînziana I Oncioiu and Massimiliano Orri and Michel Boivin and Marie-Claude Geoffroy and Louise Arseneault and Mara Brendgen and Frank Vitaro and Marie C Navarro and Cédric Galéra and Richard E Tremblay and Sylvana M Côté},

doi = {10.1542/peds.2019-2654},

issn = {1098-4275},

year  = {2020},

date = {2020-05-01},

journal = {Pediatrics},

volume = {145},

number = {5},

abstract = {OBJECTIVES: To describe (1) the developmental trajectories of peer victimization from 6 to 17 years of age and (2) the early childhood behaviors and family characteristics associated with the trajectories.nnMETHODS: We used data from 1760 children enrolled in the Quebec Longitudinal Study of Child Development, a population-based birth cohort. Participants self-reported peer victimization at ages 6, 7, 8, 10, 12, 13, 15, and 17 years. Participants' behavior and family characteristics were measured repeatedly between ages 5 months and 5 years.nnRESULTS: We identified 4 trajectories of peer victimization from 6 to 17 years of age: low (32.9%), moderate-emerging (29.8%), childhood-limited (26.2%), and high-chronic (11.1%). Compared with children in the low peer victimization trajectory, children in the other 3 trajectories were more likely to exhibit externalizing behaviors in early childhood, and those in the high-chronic and moderate-emerging trajectories were more likely to be male. Paternal history of antisocial behavior was associated with moderate-emerging (odds ratio [OR] = 1.54; 95% confidence interval [CI] = 1.09-2.19) and high-chronic (OR = 1.93; 95% CI = 1.25-2.99) relative to low peer victimization. Living in a nonintact family in early childhood was associated with childhood-limited (OR = 1.48; 95% CI = 1.11-1.97) and high-chronic (OR = 1.59; 95% CI = 1.09-2.31) relative to low peer victimization.nnCONCLUSIONS: Early childhood externalizing behaviors and family vulnerabilities were associated with the development of peer victimization. Some children entered the cascade of persistent peer victimization at the beginning of primary school. Support to these children and their families early in life should be an important component of peer victimization preventive interventions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31029623,

title = {In-utero and perinatal influences on suicide risk: a systematic review and meta-analysis},

author = {Massimiliano Orri and David Gunnell and Stephane Richard-Devantoy and Despina Bolanis and Jill Boruff and Gustavo Turecki and Marie-Claude Geoffroy},

doi = {10.1016/S2215-0366(19)30077-X},

issn = {2215-0374},

year  = {2019},

date = {2019-06-01},

journal = {Lancet Psychiatry},

volume = {6},

number = {6},

pages = {477--492},

abstract = {BACKGROUND: Adverse in-utero and perinatal conditions might contribute to an increased suicide risk throughout the lifespan; however, existing evidence is sparse and contradictory. We aimed to investigate in-utero and perinatal exposures associated with suicide, suicide attempt, and suicidal ideation.nnMETHODS: We did a systematic review and meta-analysis and searched MEDLINE, Embase, and PsycINFO from inception to Jan 24, 2019, for population-based prospective studies that investigated the association between in-utero and perinatal factors and suicide, suicide attempt, and suicidal ideation. Only papers published in English in peer-reviewed journals were considered. Two researchers independently extracted formal information (eg, country, year, duration of follow-up) and number of cases and non-cases exposed and non-exposed to each risk factor. We calculated pooled odds ratios (ORs) with 95% CIs using random-effects models and used meta-regression to investigate heterogeneity. This study was registered with PROSPERO, number CRD42018091205.nnFINDINGS: We identified 42 eligible studies; they had a low risk of bias (median quality score 9/9 [IQR 8-9]). Family or parental characteristics, such as high birth order (eg, for fourth-born or later-born vs first-born, pooled OR 1·51 [95% CIs 1·21-1·88]), teenage mothers (1·80 [1·52-2·14]), single mothers (1·57 [1·31-1·89]); indices of socioeconomic position, such as low maternal (1·36 [1·28-1·46]) and paternal (1·38 [1·27-1·51]) education; and fetal growth (eg, low birthweight 1·30 [1·09-1·55] and small for gestational age 1·18 [1·00-1·40]) were associated with higher suicide risk. Father's age, low gestational age, obstetric characteristics (eg, caesarean section), and condition or exposure during pregnancy (eg, maternal smoking or hypertensive disease) were not associated with higher suicide risk. Similar patterns of associations were observed for suicide attempt and suicidal ideation; however, these results were based on a lower number of studies. In meta-regression, differences in length of follow-up explained most between-study heterogeneity (inital I ranged from 0 to 79·5).nnINTERPRETATION: These findings suggest that prenatal and perinatal characteristics are associated with increased suicide risk during the life course, supporting the developmental origin of health and diseases hypothesis for suicide. The low number of studies for some risk factors, especially for suicide attempt and ideation, leaves gaps in knowledge that need to be addressed. The mechanisms underlying the reported associations and their causal nature still remain unclear.nnFUNDING: Horizon 2020 (EU).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid30577945,

title = {Pathways of Association Between Childhood Irritability and Adolescent Suicidality},

author = {Massimiliano Orri and Cedric Galera and Gustavo Turecki and Michel Boivin and Richard E Tremblay and Marie-Claude Geoffroy and Sylvana M Côté},

doi = {10.1016/j.jaac.2018.06.034},

issn = {1527-5418},

year  = {2019},

date = {2019-01-01},

journal = {J Am Acad Child Adolesc Psychiatry},

volume = {58},

number = {1},

pages = {99--107.e3},

abstract = {OBJECTIVE: Childhood irritability predicts suicidal ideation/attempt (suicidality), but it is unclear whether irritability is an independent and direct risk factor for suicidality or a marker of intermediate mental health symptoms associated with suicidality. This study aimed to identify developmental patterns of childhood irritability and to test whether childhood irritability is directly associated with suicidality or indirectly associated with intermediate mental health symptoms.nnMETHOD: One thousand three hundred ninety-three participants from the Québec Longitudinal Study of Child Development were followed from birth to 17 years. Teachers assessed irritability yearly (at 6-12 years) and children self-reported intermediate mental health symptoms (depression, anxiety, disruptiveness, and hyperactivity-impulsivity; at 13 years) and suicidality (at 15 and 17 years).nnRESULTS: Four irritability trajectories were identified: low (74.7%), rising (13.0%), declining (7.4%), and persistent (5.0%). Children following a rising irritability trajectory (versus a low trajectory) were at higher suicidality risk. A large proportion of this association was direct (odds ratio 2.11, 95% CI 1.30-3.43) and a small proportion was indirect by depressive symptoms (accounting for 23% of the association; odds ratio 1.17, 95% CI 1.03-1.34). Children on a persistent irritability trajectory (versus a low trajectory) were at higher risk of suicidality and this association was uniquely indirect by depressive symptoms (accounting for 73% of the association; odds ratio 1.51, 95% CI 1.16-1.97). The declining trajectory was not related to suicidality; no association with anxiety, disruptiveness, and hyperactivity-impulsivity was found.nnCONCLUSION: Rising irritability across childhood represents a direct risk for suicidality. Persistent irritability appears to be a distal marker of suicidality acting through more proximal depressive symptoms.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid30522737,

title = {Why Is Maternal Depression Related to Adolescent Internalizing Problems? A 15-Year Population-Based Study},

author = {Sylvana M Côté and Marilyn N Ahun and Catherine M Herba and Mara Brendgen and Marie-Claude Geoffroy and Massimiliano Orri and Xuecheng Liu and Frank Vitaro and Maria Melchior and Michel Boivin and Richard E Tremblay},

doi = {10.1016/j.jaac.2018.04.024},

issn = {1527-5418},

year  = {2018},

date = {2018-12-01},

journal = {J Am Acad Child Adolesc Psychiatry},

volume = {57},

number = {12},

pages = {916--924},

abstract = {OBJECTIVE: Exposure to maternal depression during early childhood is a well-documented risk factor for offspring's internalizing problems, but the long-term risk and the psychosocial mechanisms underlying the association remain largely unknown. We examined whether maternal depression during early childhood was associated with offspring internalizing problems in adolescence, and the extent to which negative parenting, peer victimization, and poor friendship quality during middle childhood mediated this association.nnMETHOD: We report on a population-based sample of children (n = 1,443) followed-up from 5 months to 15 years. We use yearly assessments of the exposure variable, that is, maternal depression (5 months to 5 years); the putative mediators, that is, peer victimization, friendship quality, and parenting practices (6-12 years); and assessment of the outcome variables at 15 years: self-reported major depressive (MD), generalized anxiety (GA), and social phobia (SP) symptoms. Structural equation modeling was used to test mediation by peer and family relationships.nnRESULTS: Exposure to maternal depression during early childhood was associated with higher levels of adolescent MD, GA, and SP. Peer victimization was the only significant mediator and explained 35.9% of the association with adolescent MD, 22.1% of that with GA, and 22.1% of that with SP.nnCONCLUSION: Exposure to maternal depression prior to age 5 years was associated with depression, anxiety, and social phobia extending to adolescence via its impact on peer victimization during middle childhood. Particular attention should be paid to victimization as one potential psychosocial factor via which maternal depression is associated with adolescent internalizing problems.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid30025311,

title = {Association between irritability and suicide-related outcomes across the life-course. Systematic review of both community and clinical studies},

author = {Massimiliano Orri and Lea C Perret and Gustavo Turecki and Marie-Claude Geoffroy},

doi = {10.1016/j.jad.2018.07.010},

issn = {1573-2517},

year  = {2018},

date = {2018-10-01},

journal = {J Affect Disord},

volume = {239},

pages = {220--233},

abstract = {BACKGROUND: Irritability is gaining considerable attention as a risk factor for suicide-related outcomes (suicide mortality, attempt, and ideation). However, the evidence of this association is scant. We conducted a systematic review of the evidence regarding the associations between irritability and suicide-related outcomes across the life-course.nnMETHODS: We conducted a systematic search on Medline and PsycINFO (up to January 2018) for original articles published in English investigating the association between irritability and suicide-related outcomes. Two researchers independently screened the articles, assessed the quality of the evidence (New-Castle-Ottawa Scale) and extracted study characteristics.nnRESULTS: Thirty-nine studies were retrieved, most were of low/medium quality. Twelve assessed irritability in childhood/adolescence (6 in community samples, 6 in clinical samples) and 27 in adulthood (7 in community samples, 20 in clinical samples). In both childhood/adolescence and adult samples, most community-based studies reported a positive association between irritability and suicidal ideation and/or attempt, while clinical studies reported mixed findings. More specifically, in clinical studies, the association of irritability with suicide-related outcomes (i) was not supported among adult depressed patients, (ii) findings were inconsistent in adult bipolar patients, (iii) for inpatients/outpatients with various psychiatric disorders/conditions, association was observed in adulthood but not in childhood/adolescence.nnLIMITATIONS: Differences in methodology and definition/measurement of irritability limited the comparability of included studies.nnCONCLUSIONS: Although irritability has been proposed as a promising transdiagnostic factor associated with suicide-related outcomes, the absence of consensus in the definition of irritability (vs anger or reactive/impulsive aggression), the poor methodological quality, and the lack of developmental considerations mitigate the conclusions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}