@article{pmid40155560,

title = {Links between climate change and suicidal behavior risks},

author = {Francis Vergunst and Massimiliano Orri and Alberto Forte and Marie-Claude Geoffroy},

doi = {10.1038/s41591-025-03528-7},

issn = {1546-170X},

year  = {2025},

date = {2025-05-01},

journal = {Nat Med},

volume = {31},

number = {5},

pages = {1391--1393},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39901502,

title = {The Relationship Between Family Dynamics and Help-Seeking and Disclosure of Adolescent Self-Harm and Suicidality: A Population-Representative Study: Relation entre dynamique familiale et recherche d'aide, et dévoilement des actes d'automutilation et de la suicidalité chez les adolescents : étude représentative de la population},

author = {Nicole G Hammond and Christopher Gravel and Mark A Ferro and Hannah Landry and Marie-Claude Geoffroy and Nicole Racine and Ian Colman},

doi = {10.1177/07067437251315526},

issn = {1497-0015},

year  = {2025},

date = {2025-05-01},

journal = {Can J Psychiatry},

volume = {70},

number = {5},

pages = {404--413},

abstract = {BackgroundFew studies have explored the potential for family dynamics to hinder or promote help-seeking and disclosure behaviours among adolescents who self-harm or experience suicidality. We sought to examine whether family dynamics may influence self-harm-related disclosure to parents or other family members and online help-seeking.MethodsWe identified youths, 14-17 years, in the 2014 Ontario Child Health Study (OCHS) who self-reported past-year suicidal ideation (with or without a suicide plan or past suicide attempt[s]) and/or non-suicidal self-harm. The OCHS is a provincially representative, cross-sectional survey. The person most knowledgeable about the adolescent, usually the mother, reported family dynamics: family dysfunction and positive and negative parenting practices. We used logistic regression to generate adjusted odds ratios.ResultsA total of 359 adolescents positively endorsed past-year suicidal ideation and/or non-suicidal self-harm. Disclosure and help-seeking were common (≥67.3% and ≥25.6%, respectively). Adolescents experiencing suicidal ideation and greater family dysfunction were more likely to share their suicidal thoughts with non-family compared to not telling anyone (OR = 1.09, 95% CI: 1.01 to 1.18) and were less likely to tell their parents or other family members about their suicidal thoughts when compared to non-family such as teachers, partners, or friends (OR = 0.82, 95% CI: 0.71 to 0.94). Positive parenting was not associated with any form of disclosure or online help-seeking for non-suicidal self-harm or suicidal ideation. As adolescent exposure to negative parenting increased, so did the likelihood that they would seek help online for their suicidal thoughts (OR = 1.22, 95% CI: 1.08 to 1.37). Sensitivity analyses replicated or were very similar to findings from the main models.ConclusionWe found that negative family dynamics were related to reduced sharing of suicidal thoughts with parents or other family members and greater online help-seeking. Our findings suggest that the importance of negative family dynamics to disclosure and support-seeking for adolescent suicidality may be under-recognized.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40185901,

title = {Joint contribution of polygenic scores for depression and attention-deficit/hyperactivity disorder to youth suicidal ideation and attempt},

author = {Massimiliano Orri and Genevieve Morneau-Vaillancourt and Isabelle Ouellet-Morin and Samuele Cortese and Cedric Galera and Ivan Voronin and Frank Vitaro and Mara R Brendgen and Ginette Dionne and Stephane Paquin and Alberto Forte and Gustavo Turecki and Richard E Tremblay and Sylvana M Côté and Marie-Claude Geoffroy and Michel Boivin},

doi = {10.1038/s41380-025-02989-z},

issn = {1476-5578},

year  = {2025},

date = {2025-04-01},

journal = {Mol Psychiatry},

abstract = {Children presenting comorbid attention-deficit/hyperactivity disorder (ADHD) and depression symptoms have higher risks of later suicidal ideation and attempt. However, it is unclear to what extent this risk stems from individual differences in the genetic predisposition for ADHD and/or depression. We investigated the unique and combined contribution of genetic predisposition to ADHD and depression to suicidal ideation and attempt by early adulthood. Data were from two longitudinal population-based birth cohorts, the Quebec Longitudinal Study of Child Development and the Quebec Newborn Twin Study (total N = 1207). Genetic predisposition for ADHD and depression were measured using polygenic scores. Suicidal ideation and attempt by age 20 years were self-reported via questionnaires. Across the two cohorts, suicidal ideation and attempt were reported by 99 (8.2%) and 75 (6.1%) individuals, respectively. A higher polygenic score for depression was associated with significantly higher risk of suicidal ideation and attempt, while no significant associations were found for ADHD polygenic score. However, we found an interaction between polygenic scores for depression and ADHD in the association with suicide attempt (P = 0.012), but not suicidal ideation (P = 0.897). The association between polygenic score for depression and suicide attempt was significantly stronger for individuals with a higher polygenic score for ADHD. Individuals scoring ≥ 1-SD above the mean for both polygenic scores were at increased risk for suicide attempt compared to individuals with lower scores (OR 4.03, CI 1.64-9.90), as well as compared to individuals scoring ≥ 1-SD above the mean in only depression (OR 2.92, CI 1.01-8.50) or only ADHD (OR 4.88, CI 1.56-15.26) polygenic scores. Our findings suggest that genetic predisposition for ADHD and depression contributes to increase the risk of suicide attempt in a multiplicative, rather that additive, way. Our results contribute to our understanding of the etiology of suicide risk and may inform screening and risk stratification.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39893761,

title = {Construct validity of probable child maltreatment indicators using prospectively recorded information in a longitudinal cohort of Canadian children},

author = {Rachel Langevin and Isabelle Ouellet-Morin and Sebastian Kay and Elise Chartrand and Natalie Castellanos-Ryan and Delphine Collin-Vezina and Marie-Claude Geoffroy},

doi = {10.1016/j.chiabu.2025.107300},

issn = {1873-7757},

year  = {2025},

date = {2025-03-01},

journal = {Child Abuse Negl},

volume = {161},

pages = {107300},

abstract = {BACKGROUND: Officially reported and self-reported measures of child maltreatment show poor agreement and may differentially predict psychosocial problems in adulthood. However, research remains primarily based on retrospective self-reports, warranting examination of the validity of prospective assessments of maltreatment.nnOBJECTIVE: To assess the construct validity of prospective indicators of child maltreatment using a longitudinal cohort of Canadian children.nnPARTICIPANTS AND SETTING: The population-based cohort comprises 2120 participants born between 1997 and 1998 in Quebec, Canada.nnMETHODS: Maternal and familial risk factors (maternal age, depressive symptoms, and antisocial behaviors, socioeconomic status, and single-parent home) and early adulthood functioning difficulties (depression, anxiety, suicidality, alcohol misuse, and unemployment status) were assessed across various time points (0-23 years). Associations between factors and prospective and retrospective maltreatment indicators were appraised.nnRESULTS: Most maternal and familial risk factors (80 %) showed associations with indicators of prospective maltreatment (ΔM = +/-0.04 to 0.72; p < 0.05). Several early adulthood functioning difficulties (30 %) showed associations with physical (ΔM = 0.05 to 0.22; p < 0.05) and sexual abuse (ΔM = 0.33 to 0.34; p < 0.05), while emotional, supervisory, and physical neglect were only associated with educational/employment status (ΔM = 0.04 to 0.10; p < 0.05). Cumulatively assessed maltreatment also showed a dose-response relationship with maternal and familial risk factors/functioning difficulties.nnCONCLUSIONS: The strong construct validity exhibited by our prospective indicators highlights the need to assess child maltreatment multi-modally. Our findings further contribute to the wider discussion surrounding the measurement of child maltreatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39428944,

title = {A longitudinal study of adolescent pathways differentiating suicide ideation and attempt in early adulthood},

author = {Geneviève Morneau-Vaillancourt and Massimiliano Orri and Isabelle Ouellet-Morin and Marie-Claude Geoffroy and Michel Boivin},

doi = {10.1002/jad.12427},

issn = {1095-9254},

year  = {2025},

date = {2025-02-01},

journal = {J Adolesc},

volume = {97},

number = {2},

pages = {395--408},

abstract = {OBJECTIVE: Suicide ideation and attempt are leading risk factors for mortality in young adults. However, the adolescent risk factors distinguishing suicide ideation from attempt in young adults remain unclear. The present study aimed to examine the extent to which within-person stability and change in depressive symptoms, school difficulties, and peer victimization from ages 12 to 17 were differentially associated with later suicide ideation and attempt from ages 20 to 23.nnMETHOD: The study included 1647 participants from the Quebec Longitudinal Study of Child Development (QLSCD; 52% female). Participants reported on their depressive symptoms, school difficulties, and peer victimization at ages 12, 13, 15, and 17, and on suicide ideation and attempt at ages 20 and 23. Data were collected in the Province of Quebec, Canada, between 2010 and 2021.nnRESULTS: Results indicated that 11% (N = 121) and 8% (N = 86) reported suicide ideation and attempt, respectively, between ages 20 and 23. A random-intercept cross-lagged panel model showed that within-person increases in depressive symptoms during adolescence were related to both suicide ideation and attempt, whereas within-person increases in school difficulties and peer victimization were for the most part related to suicide attempt only. Within-person stability in depressive symptoms from ages 12 to 17 years were also related to suicide attempt, and not ideation. However, this association was only marginally significant.nnCONCLUSION: Findings suggest that experiencing unusual rises in school difficulties and peer victimization during adolescence, as well as depressive symptoms persisting over time, may distinguish young adults who think about suicide from those who attempt suicide.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38767000,

title = {Psychotic-like experiences and associated factors in resident physicians: A Canadian cross-sectional study},

author = {Vincent Paquin and Emilie Guay and Christophe Moderie and Camille Paradis and Nima Nahiddi and Frederick L Philippe and Marie-Claude Geoffroy},

doi = {10.1111/eip.13564},

issn = {1751-7893},

year  = {2025},

date = {2025-01-01},

journal = {Early Interv Psychiatry},

volume = {19},

number = {1},

pages = {e13564},

abstract = {AIM: Medical residency training is associated with a range of sociodemographic, lifestyle and mental health factors that may confer higher risk for psychotic-like experiences (PLEs) in residents, yet little research has examined this question. Thus, we aimed to document the prevalence and associated factors of PLEs among resident physicians.nnMETHODS: Physicians enrolled in residency programmes in the Province of Québec, Canada (four universities) were recruited in Fall 2022 via their programme coordinators and social media. They completed an online questionnaire assessing PLEs in the past 3 months (the 15-item Community Assessment of Psychic Experiences), as well as sociodemographic characteristics, lifestyle and mental health. Analyses included survey weights and gamma regressions.nnRESULTS: The sample included 502 residents (mean age, 27.6 years; 65.9% women). Only 1.3% (95% CI: 0.5%, 4.0%) of residents met the screening cut-off for psychotic disorder. Factors associated with higher scores for PLEs included racialised minority status (relative difference: +7.5%; 95% CI: +2.2%, +13.2%) and English versus French as preferred language (relative difference: +7.9% 95% CI: +3.1%, +12.9%), as well as each additional point on scales of depression (relative difference: +0.8%; 95% CI: +0.3%, +1.3%) and anxiety (relative difference: +1.3%; 95% CI: +0.8%, +1.7%). In secondary analyses, racialised minority status was associated with persecutory items, but not with other PLEs. Gender, residency programmes and lifestyle variables were not associated with PLEs.nnCONCLUSIONS: This study found low reports of PLEs in a sample of resident physicians. Associations of PLEs with minoritised status may reflect experiences of discrimination.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39367209,

title = {Body mass index across development and adolescent hair cortisol: the role of persistence, variability, and timing of exposure},

author = {Christina Y Cantave and Paula L Ruttle and Sylvana M Coté and Sonia J Lupien and Marie-Claude Geoffroy and Frank Vitaro and Mara Brendgen and Richard Tremblay and Michel Boivin and Isabelle Ouellet-Morin},

doi = {10.1038/s41366-024-01640-1},

issn = {1476-5497},

year  = {2025},

date = {2025-01-01},

journal = {Int J Obes (Lond)},

volume = {49},

number = {1},

pages = {125--132},

abstract = {BACKGROUND: Research suggests a putative role of the glucocorticoid stress hormone cortisol in the accumulation of adiposity. However, obesity and weight fluctuations may also wear and tear physiological systems promoting adaptation, affecting cortisol secretion. This possibility remains scarcely investigated in longitudinal research. This study tests whether trajectories of body mass index (BMI) across the first 15 years of life are associated with hair cortisol concentration (HCC) measured two years later and whether variability in BMI and timing matter.nnMETHODS: BMI (kg/m) was prospectively measured at twelve occasions between age 5 months and 15 years. Hair was sampled at age 17 in 565 participants. Sex, family socioeconomic status, and BMI measured concurrently to HCC were considered as control variables.nnRESULTS: Latent class analyses identified three BMI trajectories: "low-stable" (59.2%, n = 946), "moderate" (32.6%, n = 507), and "high-rising" (8.2%, n = 128). BMI variability was computed by dividing the standard deviation of an individual's BMI measurements by the mean of these measurements. Findings revealed linear effects, such that higher HCC was noted for participants with moderate BMI trajectories in comparison to low-stable youth (β = 0.10, p = 0.03, 95% confidence interval (CI) = [0.02-0.40]); however, this association was not detected in the high-rising BMI youth (β = -0.02, p = 0.71, 95% CI = [-0.47-0.32]). Higher BMI variability across development predicted higher cortisol (β = 0.17, p = 0.003, 95% CI = [0.10-4.91]), additively to the contribution of BMI trajectories. BMI variability in childhood was responsible for that finding, possibly suggesting a timing effect.nnCONCLUSIONS: This study strengthens empirical support for BMI-HCC association and suggests that more attention should be devoted to BMI fluctuations in addition to persistent trajectories of BMI.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39069958,

title = {Sleep, chronotype, social jetlag, and mental health in resident physicians: a cross-sectional study},

author = {Christophe Moderie and Camille Paradis and Frederick L Philippe and Marie-Claude Geoffroy and Emilie Guay and Vincent Paquin},

doi = {10.5664/jcsm.11288},

issn = {1550-9397},

year  = {2024},

date = {2024-12-01},

journal = {J Clin Sleep Med},

volume = {20},

number = {12},

pages = {1915--1922},

abstract = {STUDY OBJECTIVES: Social jetlag, the difference between imposed and endogenous sleep schedules, may be detrimental to resident physicians' health. The current profiles of sleep habits, particularly the differences between workdays and free days, are unknown in that population. This cross-sectional study of Quebec resident physicians aimed at assessing sleep habits on workdays and free days and predictors of social jetlag.nnMETHODS: Residents were recruited via their residency programs and social media to complete an online questionnaire. Measures included means of sleep duration and timing, chronotype, sleep debt, sleep disturbances, and social jetlag. A range of sociodemographic variables, lifestyle characteristics, and mental health indicators were examined as predictors of severe social jet lag using logistic regressions.nnRESULTS: A total of 492 residents were included in the study (mean [standard deviation] age, 27.6 [3.6] years; 330 females [67.1%]). The mean sleep duration was 7.15 hours (95% confidence interval [CI], 7.02-7.28 hours) on workdays and 8.36 hours (95% CI, 8.18-8.54 hours) on free days. The mean sleep debt was 1.59 hours (95% CI, 1.37-1.81 hours), and mean social jetlag was 1.37 hours (95% CI, 1.28-1.47 hours), with 31.9% (95% CI, 25.0-39.6%) of residents experiencing ≥2 hours of sleep debt and 21.8% (95% CI, 16.5-28.3%) experiencing severe social jetlag. The prevalence of sleep disturbances was 51.7% (95% CI, 44.4-58.8%). Severe social jetlag was associated with earlier stage of training, later chronotype, decreased physical activity, increased sleep debt, and depressive symptoms.nnCONCLUSIONS: Many residents experience severe social jetlag, chronic sleep deprivation, and sleep disturbances. Importantly, severe social jetlag was associated with depressive symptoms, suggesting a potential intervention target for promoting residents' mental health.nnCITATION: Moderie C, Paradis C, Philippe FL, Geoffroy M-C, Guay E, Paquin V. Sleep, chronotype, social jetlag, and mental health in resident physicians: a cross-sectional study.  2024;20(12):1915-1922.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39041545,

title = {Comparison of concordance and predictive validity of head injuries from parental reports and medical records},

author = {Olivia E Gunther and Mathilde Garneau and Marie-Claude Geoffroy and Alexa Martin-Storey and Eric Latimer and Michèle Déry and Caroline E Temcheff},

doi = {10.1080/02699052.2024.2381046},

issn = {1362-301X},

year  = {2024},

date = {2024-12-01},

journal = {Brain Inj},

volume = {38},

number = {14},

pages = {1220--1226},

abstract = {OBJECTIVE: To examine agreement between parental reports of head injury and evidence of head injury in medical records and to compare these two measures in predicting early conduct disorder (CD).nnDESIGN AND SETTING: Parent survey data was compared with records of child head injury from the National Health Services Register (Régie de l'assurance maladie du Québec, RAMQ) administrative database.nnPARTICIPANTS: Children ( = 685) ages 6-9 with and without CD. There were 147 children with RAMQ recorded head injury and 39 children with parent-reported head injury.nnMAIN MEASURES: Indication of one or more head injury before 6 years of age as reported by parents and/or as noted in medical data. Early CD (present by age 9) according to parents and/or teachers.nnRESULTS: Results indicated poor agreement between the two forms of reporting κ = .161 (95% CI, .083 to .239),  < 0.001. Medical data significantly predicted the presence of CD in children, with a RAMQ coded head injury suggesting a child was 1.88 times more likely to have CD. Parent reports of head injuries did not significantly predict CD. Conclusion: Medical data should be prioritized in research addressing pediatric head injury, given that parent reports may fail to capture incidence of injury and therefore may be less predictive of other known correlates of head injury.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39546315,

title = {A Nature-Based Intervention and Mental Health of Schoolchildren: A Cluster Randomized Clinical Trial},

author = {Tianna Loose and Julia Fuoco and Catherine Malboeuf-Hurtubise and Jean-Philippe Ayotte-Beaudet and Lise Gauvin and Nicholas Chadi and Isabelle Ouellet-Morin and Benoît Mâsse and Sylvana M Côté and Marie-Claude Geoffroy},

doi = {10.1001/jamanetworkopen.2024.44824},

issn = {2574-3805},

year  = {2024},

date = {2024-11-01},

journal = {JAMA Netw Open},

volume = {7},

number = {11},

pages = {e2444824},

abstract = {IMPORTANCE: Nature-based therapeutic or preventive interventions for mental health are increasingly popular, but their effectiveness for improving mental health is not well documented.nnOBJECTIVE: To investigate the effectiveness of the Open Sky School Program (École à Ciel Ouvert), a 12-week nature-based intervention for elementary schoolchildren in grades 5 and 6, for reducing mental health symptoms.nnDESIGN, SETTING, AND PARTICIPANTS: This 2-arm, cluster randomized clinical trial was conducted from February 27 to June 16, 2023, in French-language elementary schools in Quebec, Canada, with green space within 1 km. Participants were teachers and students in grades 5 and 6.nnINTERVENTION: In the intervention group, for 2 hours per week for 12 weeks, classes were taught outdoors in a nearby park or wooded area. Teachers were encouraged to engage students in basic subjects and in 10 or more mental health activities (mindfulness, philosophy, and/or art therapy). Control group schools conducted classes as usual.nnMAIN OUTCOMES AND MEASURES: The primary outcome was change in student mental health (internalizing and externalizing symptoms, social problems) based on teacher- and student-reported 30-item Social Behavior Questionnaire (SBQ) scores (3-point scale) from baseline to the immediate postintervention follow-up, assessed in per-protocol and intent-to-treat mixed-model analyses. Secondary outcomes were student self-reported changes in depressive symptoms, positive or negative affect, pro-environmental efforts and/or attitudes, and nature connectedness.nnRESULTS: A total of 33 schools participated (53 teachers, 1015 students), including 16 schools (25 teachers, 515 students) in the intervention group and 17 schools (28 teachers, 500 students) in the control group. Student mean (SD) age was 10.9 (0.75) years; 507 (50.7%) were girls. Per-protocol and intent-to-treat mixed-model analyses showed no differences in mental health symptom change between groups; for example, the adjusted mean difference in SBQ scores between the intervention and control groups for externalizing symptoms was -0.04 (95% CI, -0.13 to 0.04) in the intent-to-treat analysis and -0.06 (95% CI, -0.16 to 0.04) in the per-protocol analysis. Post hoc analyses revealed low mental health symptoms at baseline, with low variability. Slightly greater reductions in symptoms were observed in the intervention group, but only for children with higher mental health symptoms at baseline (P < .05 for interaction). For example, for children with internalizing symptoms 1 SD above the mean at baseline, internalizing symptoms decreased by 0.38 SD (mean change, -0.15; P < .001) in the intervention group vs the control group.nnCONCLUSIONS AND RELEVANCE: In this large cluster randomized clinical trial in daily-life elementary school settings, 12 weeks of classes in green space for 2 hours per week did not reduce mental health symptoms in students aged 10 to 12 years in either the per-protocol or the intent-to-treat analysis. However, this low-cost, safe outdoor intervention may provide unmeasured or longer-term benefits for children with higher risk of mental health symptoms.nnTRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05662436.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39465601,

title = {Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort},

author = {Sara Scardera and Marie-Claude Geoffroy and Rachel Langevin and Lea C Perret and Delphine Collin-Vézina and Ivan Voronin and Jean-Philippe Gouin and Xiangfei Meng and Michel Boivin and Isabelle Ouellet-Morin},

doi = {10.1017/S0954579424001688},

issn = {1469-2198},

year  = {2024},

date = {2024-10-01},

journal = {Dev Psychopathol},

pages = {1--12},

abstract = {Childhood maltreatment is linked with later depressive symptoms, but not every maltreated child will experience symptoms later in life. Therefore, we investigate whether genetic predisposition for depression (i.e., polygenic score for depression, PGS) modifies the association between maltreatment and depressive symptoms, while accounting for different types of maltreatment and whether it was evaluated through prospective and retrospective reports. The sample included 541-617 participants from the Quebec Longitudinal Study of Child Development with information on maltreatment, including threat, deprivation, assessed prospectively (5 months-17 years) and retrospectively (reported at 23 years), PGS and self-reported depressive symptoms (20-23 years). Using hierarchical linear regressions, we found that retrospective, but not prospective indicators of maltreatment (threat/deprivation/cumulative) were associated with later depressive symptoms, above and beyond the PGS. Our findings also show the presence of gene-environment interactions, whereby the association between maltreatment (retrospective cumulative maltreatment/threat, prospective deprivation) and depression was strengthened among youth with higher PGS scores. Consistent with the Diathesis-Stress hypothesis, our findings suggest that a genetic predisposition for depression may exacerbate the putative impact of maltreatment on later depressive symptoms, especially when maltreatment is retrospective. Understanding the gene-environment interplay emerging in the context of maltreatment has the potential to guide prevention efforts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39356509,

title = {Mental Disorders and Suicidality in Transgender and Gender-Diverse People},

author = {Heidi Eccles and Alex Abramovich and Karen A Patte and Tara Elton-Marshall and Nicole Racine and Mark A Ferro and Jordan Edwards and Kelly K Anderson and Tracie O Afifi and Marie-Claude Geoffroy and Mila Kingsbury and Ian Colman},

doi = {10.1001/jamanetworkopen.2024.36883},

issn = {2574-3805},

year  = {2024},

date = {2024-10-01},

journal = {JAMA Netw Open},

volume = {7},

number = {10},

pages = {e2436883},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38471107,

title = {Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study},

author = {Tiffany Dal Santo and Danielle B Rice and Marie-Eve Carrier and Gabrielle Virgili-Gervais and Brooke Levis and Linda Kwakkenbos and Meira Golberg and Susan J Bartlett and Amy Gietzen and Karen Gottesman and Geneviève Guillot and Marie Hudson and Laura K Hummers and Vanessa L Malcarne and Maureen D Mayes and Luc Mouthon and Michelle Richard and Maureen Sauvé and Robyn K Wojeck and Marie-Claude Geoffroy and Andrea Benedetti and Brett D Thombs and },

doi = {10.1093/rheumatology/keae162},

issn = {1462-0332},

year  = {2024},

date = {2024-10-01},

journal = {Rheumatology (Oxford)},

volume = {63},

number = {10},

pages = {2660--2669},

abstract = {OBJECTIVES: To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors.nnMETHODS: Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of the Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used to assess associations of sociodemographic, lifestyle, and disease-related variables.nnRESULTS: Among 2385 participants, the mean physical function T-score (43.7, SD = 8.9) was ∼2/3 of a standard deviation (SD) below the US general population (mean = 50, SD = 10). Factors associated in the multivariable analysis included older age (-0.74 points per SD years, 95% CI -0.78 to -1.08), female sex (-1.35, -2.37 to -0.34), fewer years of education (-0.41 points per SD in years, -0.75 to -0.07), being single, divorced, or widowed (-0.76, -1.48 to -0.03), smoking (-3.14, -4.42 to -1.85), alcohol consumption (0.79 points per SD drinks per week, 0.45-1.14), BMI (-1.41 points per SD, -1.75 to -1.07), diffuse subtype (-1.43, -2.23 to -0.62), gastrointestinal involvement (-2.58, -3.53 to -1.62), digital ulcers (-1.96, -2.94 to -0.98), moderate (-1.94, -2.94 to -0.93) and severe (-1.76, -3.24 to -0.28) small joint contractures, moderate (-2.10, -3.44 to -0.76) and severe (-2.54, -4.64 to -0.44) large joint contractures, interstitial lung disease (-1.52, -2.27 to -0.77), pulmonary arterial hypertension (-3.72, -4.91 to -2.52), rheumatoid arthritis (-2.10, -3.64 to -0.56) and idiopathic inflammatory myositis (-2.10, -3.63 to -0.56).nnCONCLUSION: Physical function is impaired for many individuals with SSc and is associated with multiple disease factors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38733756,

title = {Hair steroid before and after COVID-19 in preschoolers: the moderation of family characteristics},

author = {Éloise Berger and Marie-Pier Larose and France Capuano and Marie-Josée Letarte and Marie-Claude Geoffroy and Sonia Lupien and Mara Brendgen and Michel Boivin and Frank Vitaro and Richard Tremblay and Benoît Masse and Sylvana Côté and Isabelle Ouellet-Morin},

doi = {10.1016/j.psyneuen.2024.107072},

issn = {1873-3360},

year  = {2024},

date = {2024-08-01},

journal = {Psychoneuroendocrinology},

volume = {166},

pages = {107072},

abstract = {BACKGROUND: Frequent or prolonged exposure to stressors may jeopardize young children's health. The onset of the COVID-19 pandemic, coupled with disruptions in daily routines and social isolation resulting from public health preventive measures, have raised concerns about its potential impact on children' experienced stress, particularly for young children and vulnerable families. However, whether the pandemic was accompanied by changes in physiological stress remains unknown as perceived stress is not a good proxy of physiological stress. This study examined if preschoolers showed increasing hair steroid concentrations following the onset of the COVID-19 pandemic and whether family characteristics may have exacerbated or buffered these changes.nnMETHODS: 136 preschoolers (2-4 years) provided hair for steroid measurement (cortisol, dehydroepiandrosterone (DHEA), cortisone, cortisol-to-DHEA ratio, cortisol-to-cortisone ratio) in October-November 2019 (T0) and in July-August 2020 (T1). A 2-centimeter hair segment was analyzed, reflecting steroid production over the two months leading up to collection. Family income, conflict resolution and lack of cohesion, as well as parents' COVID-19 stress were reported by parents. Linear mixed models for repeated measures and Bayes factors were used.nnRESULTS: No significant changes were noted from before to after the onset of the COVID-19 pandemic for most hair steroids. However, a moderating role of family conflict resolution was noted. Children living with parents with a better ability to resolve conflicts had lower levels of DHEA compared to those who had more difficulty managing conflicts. Additionally, lower levels of family cohesion and income were linked to some steroids, especially DHEA, suggesting that these factors may relate to children's physiological stress. Finally, boys had higher DHEA levels than girls.nnCONCLUSION: Our findings suggest that stress biomarkers were comparable from before to during the COVID-19 pandemic. This observation holds true despite the pandemic being perceived by many as a novel, unpredictable, and potentially threatening event. Findings further suggest that family characteristics are associated with hair steroid, especially DHEA, which deserves further investigation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38598210,

title = {Trajectories of Adolescent Media Use and Their Associations With Psychotic Experiences},

author = {Vincent Paquin and Manuela Ferrari and Soham Rej and Michel Boivin and Isabelle Ouellet-Morin and Marie-Claude Geoffroy and Jai L Shah},

doi = {10.1001/jamapsychiatry.2024.0384},

issn = {2168-6238},

year  = {2024},

date = {2024-07-01},

journal = {JAMA Psychiatry},

volume = {81},

number = {7},

pages = {708--716},

abstract = {IMPORTANCE: Adolescent media use is thought to influence mental health, but whether it is associated with psychotic experiences (PEs) is unclear.nnOBJECTIVE: To examine longitudinal trajectories of adolescent media use and their associations with PEs at 23 years of age.nnDESIGN, SETTING, AND PARTICIPANTS: This cohort study included participants from the Québec Longitudinal Study of Child Development (1998-2021): children who were born in Québec, Canada, and followed up annually or biennially from ages 5 months through 23 years. Data were analyzed between January 2023 and January 2024.nnEXPOSURES: Participants reported their weekly amount of television viewing, video gaming, computer use, and reading at ages 12, 13, 15, and 17 years.nnMAIN OUTCOME AND MEASURES: Lifetime occurrence of PEs was measured at 23 years of age. Covariables included sociodemographic, genetic, family, and childhood characteristics between ages 5 months and 12 years.nnRESULTS: A total of 1226 participants were included in the analyses (713 [58.2%] female, 513 [41.8%] male). For each media type, latent class mixed modeling identified 3 group-based trajectories, with subgroups following trajectories of higher use: television viewing, 128 (10.4%); video gaming, 145 (11.8%); computer use, 353 (28.8%); and reading, 140 (11.4%). Relative to lower video gaming, higher video gaming was preceded by higher levels of mental health and interpersonal problems at age 12 years. Adjusting for these risk factors mitigated the association between higher video gaming and PEs at age 23 years. The curved trajectory of computer use (189 [15.4%] participants), characterized by increasing levels of use until age 15 years followed by a decrease, was associated with higher PEs (estimated difference, +5.3%; 95% CI, +1.5% to +9.3%) relative to lower use (684 [55.8%] participants). This association remained statistically significant after covariable adjustment.nnCONCLUSIONS AND RELEVANCE: This study found that longitudinal trajectories of media use during adolescence were modestly associated with PEs at age 23 years, likely reflecting the influence of shared risk factors. Understanding the environmental determinants and psychosocial functions of media use during adolescence may help better integrate digital technologies in the prevention and management of PEs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38424142,

title = {Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multidomain task-based fMRI study},

author = {Anthony J Gifuni and Fabricio Pereira and M Mallar Chakravarty and Martin Lepage and Henri W Chase and Marie-Claude Geoffroy and Eric Lacourse and Mary L Phillips and Gustavo Turecki and Johanne Renaud and Fabrice Jollant},

doi = {10.1038/s41380-024-02485-w},

issn = {1476-5578},

year  = {2024},

date = {2024-07-01},

journal = {Mol Psychiatry},

volume = {29},

number = {7},

pages = {2135--2144},

abstract = {The occurrence of suicidal behaviors increases during adolescence. Hypersensitivity to negative social signals and deficits in cognitive control are putative mechanisms of suicidal behaviors, which necessitate confirmation in youths. Multidomain functional neuroimaging could enhance the identification of patients at suicidal risk beyond standard clinical measures. Three groups of adolescents (N = 96; 78% females, age = 11.6-18.1) were included: patients with depressive disorders and previous suicide attempts (SA, n = 29); patient controls with depressive disorders but without any suicide attempt history (PC, n = 35); and healthy controls (HC, n = 32). We scanned participants with 3T-MRI during social inclusion/exclusion (Cyberball Game) and response inhibition (Go-NoGo) tasks. Neural activation was indexed by the blood-oxygenation-level dependent (BOLD) of the hemodynamic response during three conditions in the Cyberball Game ("Control condition", "Social Inclusion", and "Social Exclusion"), and two conditions in Go-NoGo task ("Go" and "NoGo" blocks). ANCOVA-style analysis identified group effects across three whole-brain contrasts: 1) NoGo vs. Go, 2) Social inclusion vs. control condition, 3) Social exclusion vs. control condition. We found that SA had lower activation in the left insula during social inclusion vs. control condition compared to PC and HC. Moreover, SA compared to PC had higher activity in the right middle prefrontal gyrus during social exclusion vs. control condition, and in bilateral precentral gyri during NoGo vs. Go conditions. Task-related behavioral and self-report measures (Self-reported emotional reactivity in the Cyberball Game, response times and number of errors in the Go-NoGo Task) did not discriminate groups. In conclusion, adolescent suicidal behaviors are likely associated with neural alterations related to the processing of social perception and response inhibition. Further research, involving prospective designs and diverse cohorts of patients, is necessary to explore the potential of neuroimaging as a tool in understanding the emergence and progression of suicidal behaviors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38478216,

title = {Mental health of Canadian youth: A systematic review and meta-analysis of studies examining changes in depression, anxiety, and suicide-related outcomes during the COVID-19 pandemic},

author = {Marie-Claude Geoffroy and Nicholas Chadi and Samantha Bouchard and Julia Fuoco and Elise Chartrand and Tianna Loose and Anthony Sciola and Jill T Boruff and Srividya N Iyer and Ying Sun and Jean-Philippe Gouin and Sylvana M Côté and Brett D Thombs},

doi = {10.17269/s41997-024-00865-x},

issn = {1920-7476},

year  = {2024},

date = {2024-06-01},

journal = {Can J Public Health},

volume = {115},

number = {3},

pages = {408--424},

abstract = {OBJECTIVES: This systematic review and meta-analysis aims to describe Canadian youth mental health during the COVID-19 pandemic, focusing on changes in anxiety and depressive symptoms and suicidality.nnMETHODS: We searched four databases up to February 2023 for longitudinal or repeated cross-sectional studies reporting on changes in depressive and anxiety symptoms, suicidality, or related services utilization among young people under 25 years old residing in Canada during the COVID-19 pandemic. Random-effects meta-analyses were performed for studies comparing depressive and anxiety symptoms from before to during the first, second, and third COVID-19 waves (up to June 2021), and between COVID-19 waves. Other studies were described narratively. Risk of bias was assessed using an adapted Joanna Briggs Institute Checklist.nnSYNTHESIS: Of the 7916 records screened, 35 articles met inclusion criteria for this review. Included studies were highly heterogeneous in design, population, and type of change investigated, and many had a high risk of bias. The meta-analyses found that depressive symptoms worsened minimally from pre-pandemic to wave 1 but returned to pre-pandemic levels by wave 2. Anxiety symptoms were broadly comparable from pre-pandemic to waves 1 and 2 but worsened from waves 1 to 3 and from pre-pandemic to wave 1 for girls. The narrative review included several studies that provided inconclusive evidence of increases in services utilization.nnCONCLUSION: The current evidence is limited and highly heterogeneous, making it insufficient to draw definitive conclusions regarding the short- to medium-term impact of the pandemic on youth mental health in Canada. Obtaining better mental health surveillance among Canadian youth is imperative.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38342065,

title = {Association of childhood externalizing, internalizing, comorbid problems with criminal convictions by early adulthood},

author = {Melissa Commisso and Marie-Claude Geoffroy and Caroline Temcheff and Sara Scardera and Francis Vergunst and Sylvana M Côté and Frank Vitaro and Richard E Tremblay and Massimiliano Orri},

doi = {10.1016/j.jpsychires.2024.01.039},

issn = {1879-1379},

year  = {2024},

date = {2024-04-01},

journal = {J Psychiatr Res},

volume = {172},

pages = {9--15},

abstract = {Childhood externalizing problems have been linked with adult criminality. However, little is known about criminal outcomes among children with comorbid externalizing and internalizing problems. We examined the associations between profiles of behavioral problems during childhood (i.e., externalizing, internalizing, and comorbid) and criminality by early adulthood. Participants were N = 3017 children from the population-based Quebec Longitudinal Study of Kindergarten Children followed up from age 6-25. Multitrajectory modeling of teacher-rated externalizing and internalizing problems from age 6-12 years identified four distinct profiles: no/low, externalizing, internalizing, and comorbid problems. Juvenile (age 13-17) and adult (age 18-25) criminal convictions were extracted from official records. Compared to children in the no/low profile, those in the externalizing and comorbid profiles were at higher risk of having a criminal conviction, while no association was found for children in the internalizing profile. Children with comorbid externalizing and internalizing problems were most at risk of having a criminal conviction by adulthood, with a significantly higher risk when compared to children with externalizing or internalizing problems only. Similar results were found when violent and non-violent crimes were investigated separately. Specific interventions targeting early comorbid behavioral problems could reduce long-term criminality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38095215,

title = {Emotion Dysregulation Is Associated With Increased Problem Cannabis Use Among Emerging Adults During COVID-19},

author = {Nina Pocuca and Erinn Acland and Marie-Claude Geoffroy and Massimiliano Orri and Nicholas Chadi and Jean R Séguin and Sophie Parent and Michel Boivin and Richard E Tremblay and Sylvana M Côté and Natalie Castellanos-Ryan},

doi = {10.15288/jsad.23-00144},

issn = {1938-4114},

year  = {2024},

date = {2024-03-01},

journal = {J Stud Alcohol Drugs},

volume = {85},

number = {2},

pages = {261--271},

abstract = {OBJECTIVE: Emerging adulthood (18-25 years) is associated with peak prevalence of cannabis use. Although population-based longitudinal studies have found little change in cannabis use among emerging adults during COVID-19, research examining changes among vulnerable subgroups is lacking. The present study examined the association between emotion dysregulation at 23 years and change in cannabis use frequency and problem cannabis use among a large sample of emerging adults, from before to during the COVID-19 pandemic.nnMETHOD: Longitudinal data were analyzed from 1,226 emerging adults (59% female;  = 738 reported cannabis use) who completed online surveys before the pandemic (2019; age 21) and 1 year into COVID-19 (2021; age 23) as part of the Québec Longitudinal Study of Child Development.nnRESULTS: There was no significant overall within-person change in cannabis use outcomes during COVID-19 among the emerging adult sample. However, emotional clarity (a dimension of emotion dysregulation) at 23 years significantly moderated change in problem cannabis use during COVID-19. Namely, low emotional clarity at 23 years was associated with increased problem cannabis use ( = 0.79, 95% CI [0.23, 1.34]), whereas high emotional clarity at 23 years was associated with decreased problem cannabis use ( = -0.68, 95% CI [-1.27, -0.09]) during COVID-19, among men only.nnCONCLUSIONS: Findings highlight the need to consider changes in cannabis use during COVID-19 among emerging adults with elevated emotion dysregulation (and particularly, low emotional clarity among men) and reiterate the need for supports and targeted interventions to reduce cannabis use and decrease associated harms as society emerges from COVID-19.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38428973,

title = {Factors associated with satisfaction with social roles and activities among people with systemic sclerosis: a Scleroderma Patient-centered Intervention Network (SPIN) cohort cross-sectional study},

author = {Tiffany Dal Santo and Danielle Rice and Marie-Eve Carrier and Gabrielle Virgili-Gervais and Brooke Levis and Linda Kwakkenbos and Susan J Bartlett and Amy Gietzen and Karen Gottesman and Genevieve Guillot and Marie Hudson and Laura K Hummers and Vanessa Malcarne and Maureen Mayes and Luc Mouthon and Michelle Richard and Maureen Sauve and Robyn Wojeck and Marie-Claude Geoffroy and Andrea Benedetti and Brett Thombs and },

doi = {10.1136/rmdopen-2023-003876},

issn = {2056-5933},

year  = {2024},

date = {2024-02-01},

journal = {RMD Open},

volume = {10},

number = {1},

abstract = {OBJECTIVE: The objectives were to (1) compare satisfaction with social roles and activities in a large multinational systemic sclerosis (SSc) cohort to general population normative data and (2) identify sociodemographic, lifestyle and SSc disease factors associated with satisfaction with social roles and activities.nnMETHODS: Participants in the Scleroderma Patient-centered Intervention Network Cohort completed the Patient Reported Outcomes Information System Version 2 satisfaction with social roles and activities domain questionnaire. Multivariable regression was used to assess associations with sociodemographic, lifestyle and disease factors.nnRESULTS: Among 2385 participants, mean satisfaction with social roles and activities T-score (48.1, SD=9.9) was slightly lower than the US general population (mean=50, SD=10). Factors independently associated with satisfaction were years of education (0.54 per SD, 95% CI 0.14 to 0.93); non-White race or ethnicity (-1.13, 95% CI -2.18 to -0.08); living in Canada (-1.33, 95% CI -2.40 to -0.26 (reference USA)) or the UK (-2.49, 95% CI -3.92 to -1.06); body mass index (-1.08 per SD, 95% CI -1.47 to -0.69); gastrointestinal involvement (-3.16, 95% CI -4.27 to -2.05); digital ulcers (-1.90, 95% CI -3.05 to -0.76); moderate (-1.62, 95% CI -2.78 to -0.45) or severe (-2.26, 95% CI -3.99 to -0.52) small joint contractures; interstitial lung disease (-1.11, 95% CI -1.97 to -0.25); pulmonary arterial hypertension (-2.69, 95% CI -4.08 to -1.30); rheumatoid arthritis (-2.51, 95% CI -4.28 to -0.73); and Sjogren's syndrome (-2.42, 95% CI -3.96 to -0.88).nnCONCLUSION: Mean satisfaction with social roles and activities is slightly lower in SSc than the general population and associated with multiple sociodemographic and disease factors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}