- Theme-Based Group:Youth Mental Health and Early Intervention
- Division:Human Neuroscience
6875 Boulevard LaSalle
Director, Brain Imaging Centre, Douglas Research Centre
Researcher, Douglas Research Centre
Computational Neuroscientist, Brain Imaging Centre, Douglas Research Centre
Associate Professor, Department of Psychiatry, McGill University
Associate Member, Department of Biomedical Engineering, McGill University
Research Scholar, Fonds de recherche du Québec - Santé (FRQS), Junior 2
Computational brain anatomy
The Computational Brain Anatomy (CoBrA) Laboratory is located at the Cerebral Imaging Centre at the Douglas Mental Health University Institute (Verdun, QC, Canada; affiliated with McGill University). Our laboratory is interested the anatomy of the brain and how it matures through adolescence, how it stays healthy through the normal ageing process, and how alterations in brain anatomy are related to neurodegenerative disorders such as Alzheimer's and Parkinson's disease and neurodevelopmental disorders such as schizophrenia.
The CoBrA Lab uses and develops sophisticated computational neuroanatomy techniques that are able to automatically parse the geometric complexity of brain anatomy.
The members of the group come from diverse backgrounds, including neuroscientists, computer scientists, engineers, and physicists all working towards a common goal of improving our understanding of the structure-function relationships of the brain through health and illness.
We publicly disseminate much of the algorithmic and atlas work that we do in an effort to promote open and reproducible science.
1. Aristotle N. Voineskos*, Julie Winterburn*, Daniel Felsky, Jon Pipitone, Tarek K. Rajji, Benoit H. Mulsant, M. Mallar Chakravarty. Hippocampal (subfield) volume and shape in relation to cognitive performance across the adult lifespan. Human Brain Mapping, in press.
2. M. Mallar Chakravarty, Judith L. Rapoport, Jay N. Giedd, Armin Raznahan, Philip Shaw, D. Louis Collins, Jason P. Lerch*, and Nitin Gogtay*. Striatal shape abnormalities as a novel neurodevelopmental endophenotype in schizophrenia: a longitudinal study. Human Brain Mapping, 36(4):1458-1469, 2015.
3. Jon Pipitone, Min Tae Park, Julie L. Winterburn, Tristram A. Lett, Jason P. Lerch, Jens C. Pruessner, Martin Lepage, Aristotle N. Voineskos, M. Mallar Chakravarty and the Alzheimer’s Disease NeuroImaging Initiative. Multi-atlas segmentation of the whole hippocampus and subfields using multiple automatically generated templates. NeuroImage, 101(1 November):494-512, 2014.
4. Amy C. Janes, Min Tae Park, Stacey Farmer, and M. Mallar Chakravarty. Striatal morphology is associated with tobacco cigarette craving. Neuropsychopharmacology, 40(2): 406-411, 2015.
5. Philip Shaw, Pietro De Rossi, Bethany Watson, Amy Wharton, Deanna Greenstein, Armin Raznahan, Wendy Sharp, Jason P. Lerch, and M. Mallar Chakravarty. Mapping the development of the basal ganglia in children with Attention-Deficit/ Hyperactivity Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 53(7):780—9, 2014.
6. Min Tae M. Park, Jon Pipitone, Larry Baer, Julie L. Winterburn, Yashvi Shah, Sofia Chavez, Mark M. Schira, Nancy J. Lobaugh, Jason P. Lerch, Aristotle N. Voineskos, and M. Mallar Chakravarty. Derivation of high-resolution MRI atlases of the human cerebellum at 3T and segmentation using multiple automatically generated templates NeuroImage, 95(15 July 2014):217-231, 2014.
7. Armin Raznahan, Philip W. Shaw, Jason P. Lerch, Liv Clasen, Dede Greenstein, Rebecca Berman, Jon Pipitone, M. Mallar Chakravarty*, and Jay N. Giedd*. Longitudinal four-dimensional mapping of subcortical anatomy in human development. Proceedings of the National Academy of Sciences (PNAS), 111(4):1592—7, 2014.
8. Julie L. Winterburn, Jens Pruessner, Sofia Chavez, Mark Schira, Nancy J. Lobaugh, Aristotle N. Voineskos, and M. Mallar Chakravarty. A novel in vivo atlas of the human hippocampal subfields using high-resolution 3T magnetic resonance imaging. NeuroImage. 74(1 July 2013):254—65, 2013.
9. M. Mallar Chakravarty, Patrick Steadman, Matthijs C. van Eede, Rebecca D. Calcott, Victoria Gu, Philip Shaw, Armin Raznahan, D. Louis Collins, and Jason P. Lerch. Performing label-fusion based segmentation using multiple automatically generated templates. Human Brain Mapping, 34(10):2635—54, 2013.
10. Till Sprenger, Christian L. Seifert, Michael Valet, Anna P. Andreou, Annette Foerschler, Claus Zimmer, D. Louis Collins, Peter J. Goadsby, Thomas R. Tölle, and M. Mallar Chakravarty. Assessing the risk of thalamic pain by MRI lesion mapping. Brain. 135(Pt 8): 2536—45, 2012.
11. Michael J. Hawrylycz, Ed S. Lein, Angela L. Guillozet-Bongaarts, Elaine H. Shen, Lydia Ng, Jeremy A. Miller, Louie N. van de Lagemaat, Kimberly A. Smith, Amanda Ebbert, Zackery L. Riley, Chris Abajian, Christian F. Beckmann, Amy Bernard, Darren Bertagnolli, Andrew F. Boe, Preston M. Cartagena, M. Mallar Chakravarty, Mike Chapin, Jimmy Chong, Rachel A. Dalley, Barry David Daly, Chinh Dang, Suvro Datta, Nick Dee, Tim A. Dolbeare, Vance Faber, David Feng, David R Fowler, Jeff Goldy, Benjamin W. Gregor, Zeb Haradon, David R. Haynor, John G. Hohmann, Steve Horvath, Robert E. Howard, Andreas Jeromin, Jayson M. Jochim, Marty Kinnunen, Christopher Lau, Evan T. Lazarz, Changkyu Lee, Tracy A. Lemon, Ling Li, Yang Li, John A. Morris, Caroline C. Overly, Patrick D. Parker, Sheana E. Parry, Melissa Reding, Joshua J. Royall, Jay Schulkin, Pedro Adolfo Sequeira, Clifford R. Slaughterbeck, Simon C. Smith, Andy J. Sodt, Susan M. Sunkin, Beryl E. Swanson, Marquis P. Vawter, Derric Williams, Paul Wohnoutka, H. Ronald Zielke, Daniel H. Geschwind, Patrick R. Hof, Stephen M. Smith, Christof Koch, Seth G.N. Grant, Allan R. Jones. An Anatomically Comprehensive Atlas of the Adult Human Brain Transcriptome. Nature. 489 (7416): 391-9, 2012.
12. M. Mallar Chakravarty, Daniel Felsky, Maria Tampakeras, Jason P. Lerch, Benoit H. Mulsant, James L. Kennedy, and Aristotle N. Voineskos. DISC1 and striatal volume: a potential risk phenotype for mental illness. Frontiers in Neuropsychiatric Imaging and Stimulation. 3(57): 10.3389/fpsyt.2012.00057, 2012.
Mallar Chakravarty, PhD, received his Bachelor's Degree in Electrical Engineering from the University of Waterloo and his PhD in Biomedical Engineering from McGill University. He went on to do postdoctoral fellowships in Aarhus, Denmark and jointly at the Rotman Research Institute and at the Mouse Imaging Centre (MICe) and the Hospital Sick Children in Toronto, Canada. Between fellowships, Dr. Chakravarty worked at the Allen Institute for Brain Science (Seatte, WA, USA).
1. Fonds de Recherche Santé Québec - Young Investigator Award Junior 1
2. Sertuener Award for best scientific work in pain research in Germany (for work in Sprenger et al. Brain 2012; senior author)
Gabriel A. Devenyi, Ph.D.
Roberto S.C. Amaral
Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes. Neurobiol Aging. 2022;109:216-228.
Striatal glutamate, subcortical structure and clinical response to first-line treatment in first-episode psychosis patients. Prog Neuropsychopharmacol Biol Psychiatry. 2022;113:110473.
Patterns of change in cortical morphometry following traumatic brain injury in adults. Hum Brain Mapp. 2021.
Analyses of microstructural variation in the human striatum using non-negative matrix factorization. Neuroimage. 2021;246:118744.
Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice. Neuroimage Clin. 2021;32:102868.
Involvement of the habenula in the pathophysiology of autism spectrum disorder. Sci Rep. 2021;11(1):21168.
Small animal imaging presents an opportunity for improving translational research in biological psychiatry. J Psychiatry Neurosci. 2021;46(5):E579-E582.
Early musical training shapes cortico-cerebellar structural covariation. Brain Struct Funct. 2021.
Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness. Eur Arch Psychiatry Clin Neurosci. 2021.
Central nervous system atrophy predicts future dynamics of disability progression in a real-world multiple sclerosis cohort. Eur J Neurol. 2021;28(12):4153-4166.
Genetically Predicted Brain C4A Expression Is Associated With TSPO and Hippocampal Morphology. Biol Psychiatry. 2021;90(9):652-660.
Preclinical longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic. J Cereb Blood Flow Metab. 2021:271678X211035625.
Sex-specific associations between subcortical morphometry in childhood and adult alcohol consumption: A 17-year follow-up study. Neuroimage Clin. 2021;31:102771.
Effects of eight neuropsychiatric copy number variants on human brain structure. Transl Psychiatry. 2021;11(1):399.
Hippocampal shape across the healthy lifespan and its relationship with cognition. Neurobiol Aging. 2021;106:153-168.
A Diagnosis and Biotype Comparison Across the Psychosis Spectrum: Investigating Volume and Shape Amygdala-Hippocampal Differences from the B-SNIP Study. Schizophr Bull. 2021;47(6):1706-1717.
Open science datasets from PREVENT-AD, a longitudinal cohort of pre-symptomatic Alzheimer's disease. Neuroimage Clin. 2021;31:102733.
Cumulative exposure to ADHD medication is inversely related to hippocampus subregional volume in children. Neuroimage Clin. 2021;31:102695.
Brain cortical and subcortical morphology in adolescents with depression and a history of suicide attempt. J Psychiatry Neurosci. 2021;46(3):E347-E357.
Mapping autonomic, mood and cognitive effects of hypothalamic region deep brain stimulation. Brain. 2021;144(9):2837-2851.
A systematic review of neuroimaging and acute cannabis exposure in age-of-risk for psychosis. Transl Psychiatry. 2021;11(1):217.
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