Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation.
| Title | Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Bohbot VD, Copara MS, Gotman J, Ekstrom AD |
| Journal | Nat Commun |
| Volume | 8 |
| Pagination | 14415 |
| Date Published | 2017 Feb 14 |
| ISSN | 2041-1723 |
| Abstract | Low-Frequency Oscillations (LFO) in the range of 7-9 Hz, or theta rhythm, has been recorded in rodents ambulating in the real world. However, intra-hippocampus EEG recordings during virtual navigation in humans have consistently reported LFO that appear to predominate around 3-4 Hz. Here we report clear evidence of 7-9 Hz rhythmicity in raw intra-hippocampus EEG traces during real as well as virtual movement. Oscillations typically occur at a lower frequency in virtual than real world navigation. This study highlights the possibility that human and rodent hippocampal EEG activity are not as different as previously reported and this difference may arise, in part, due to the lack of actual movement in previous human navigation studies, which were virtual. |
| DOI | 10.1038/ncomms14415 |
| Alternate Journal | Nat Commun |
| PubMed ID | 28195129 |
| PubMed Central ID | PMC5316881 |
| Grant List | R01 NS076856 / NS / NINDS NIH HHS / United States R25 GM056765 / GM / NIGMS NIH HHS / United States |