Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation.

TitleLow-frequency theta oscillations in the human hippocampus during real-world and virtual navigation.
Publication TypeJournal Article
Year of Publication2017
AuthorsBohbot VD, Copara MS, Gotman J, Ekstrom AD
JournalNat Commun
Volume8
Pagination14415
Date Published2017 Feb 14
ISSN2041-1723
Abstract

Low-Frequency Oscillations (LFO) in the range of 7-9 Hz, or theta rhythm, has been recorded in rodents ambulating in the real world. However, intra-hippocampus EEG recordings during virtual navigation in humans have consistently reported LFO that appear to predominate around 3-4 Hz. Here we report clear evidence of 7-9 Hz rhythmicity in raw intra-hippocampus EEG traces during real as well as virtual movement. Oscillations typically occur at a lower frequency in virtual than real world navigation. This study highlights the possibility that human and rodent hippocampal EEG activity are not as different as previously reported and this difference may arise, in part, due to the lack of actual movement in previous human navigation studies, which were virtual.

DOI10.1038/ncomms14415
Alternate JournalNat Commun
PubMed ID28195129
PubMed Central IDPMC5316881
Grant ListR01 NS076856 / NS / NINDS NIH HHS / United States
R25 GM056765 / GM / NIGMS NIH HHS / United States

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