Linking GABA and glutamate levels to cognitive skill acquisition during development.

TitleLinking GABA and glutamate levels to cognitive skill acquisition during development.
Publication TypeJournal Article
Year of Publication2015
AuthorsKadosh KCohen, Krause B, King AJ, Near J, Kadosh RCohen
JournalHum Brain Mapp
Volume36
Issue11
Pagination4334-45
Date Published2015 Nov
ISSN1097-0193
KeywordsAdult, Child, Child Development, Facial Recognition, gamma-Aminobutyric Acid, Glutamic Acid, Gray Matter, Humans, Learning, Memory, Short-Term, Neuronal Plasticity, Prefrontal Cortex, Proton Magnetic Resonance Spectroscopy, Young Adult
Abstract

Developmental adjustments in the balance of excitation and inhibition are thought to constrain the plasticity of sensory areas of the cortex. It is unknown however, how changes in excitatory or inhibitory neurochemical expression (glutamate, γ-aminobutyric acid (GABA)) contribute to skill acquisition during development. Here we used single-voxel proton magnetic resonance spectroscopy (1H-MRS) to reveal how differences in cortical glutamate vs. GABA ratios relate to face proficiency and working memory abilities in children and adults. We show that higher glutamate levels in the inferior frontal gyrus correlated positively with face processing proficiency in the children, but not the adults, an effect which was independent of age-dependent differences in underlying cortical gray matter. Moreover, we found that glutamate/GABA levels and gray matter volume are dissociated at the different maturational stages. These findings suggest that increased excitation during development is linked to neuroplasticity and the acquisition of new cognitive skills. They also offer a new, neurochemical approach to investigating the relationship between cognitive performance and brain development across the lifespan.

DOI10.1002/hbm.22921
Alternate JournalHum Brain Mapp
PubMed ID26350618
PubMed Central IDPMC4832309
Grant List076508 / / Wellcome Trust / United Kingdom
0883781 / / Wellcome Trust / United Kingdom

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