Leveraging VGLUT3 Functions to Untangle Brain Dysfunctions.

TitleLeveraging VGLUT3 Functions to Untangle Brain Dysfunctions.
Publication TypeJournal Article
Year of Publication2021
AuthorsFavier M, Pietrancosta N, Mestikawy SEl, Gangarossa G
JournalTrends Pharmacol Sci
Volume42
Issue6
Pagination475-490
Date Published2021 06
ISSN1873-3735
KeywordsBrain, Brain Diseases, Glutamic Acid, Humans, Vesicular Glutamate Transport Proteins
Abstract

Vesicular glutamate transporters (VGLUTs) were long thought to be specific markers of glutamatergic excitatory transmission. The discovery, two decades ago, of the atypical VGLUT3 has thoroughly modified this oversimplified view. VGLUT3 is strategically expressed in discrete populations of glutamatergic, cholinergic, serotonergic, and even GABAergic neurons. Recent reports show the subtle, but critical, implications of VGLUT3-dependent glutamate co-transmission and its roles in the regulation of diverse brain functions and dysfunctions. Progress in the neuropharmacology of VGLUT3 could lead to decisive breakthroughs in the treatment of Parkinson's disease (PD), addiction, eating disorders, anxiety, presbycusis, or pain. This review summarizes recent findings on VGLUT3 and its vesicular underpinnings as well as on possible ways to target this atypical transporter for future therapeutic strategies.

DOI10.1016/j.tips.2021.03.003
Alternate JournalTrends Pharmacol Sci
PubMed ID33775453