Left lateralization of neonatal caudate microstructure affects emerging language development at 24 months.

TitleLeft lateralization of neonatal caudate microstructure affects emerging language development at 24 months.
Publication TypeJournal Article
Year of Publication2021
AuthorsTan APeng, Ngoh ZMing, Yeo SSiok Peng, Koh DXin Ping, Gluckman P, Chong YSeng, Daniel LMary, Rifkin-Graboi A, Fortier MV, Qiu A, Meaney MJ
JournalEur J Neurosci
Volume54
Issue2
Pagination4621-4637
Date Published2021 07
ISSN1460-9568
KeywordsBrain, Cross-Sectional Studies, Diffusion Tensor Imaging, Gray Matter, Humans, Infant, Newborn, Language Development, White Matter
Abstract

The complex interaction between brain and behaviour in language disorder is well established. Yet to date, the imaging literature in the language disorder field has continued to pursue heterogeneous and relatively small clinical cross-sectional samples, with emphasis on cortical structures and volumetric analyses of subcortical brain structures. In our current work, we aimed to go beyond this state of knowledge to focus on the microstructural features of subcortical brain structures (specifically the caudate nucleus) in a large cohort of neonates and study its association with emerging language skills at 24 months. Variations in neonatal brain microstructure could be interpreted as a proxy for in utero brain development. As language development is highly dependent on cognitive function and home literacy environment, we also examined their effect on the caudate-language function relationship utilizing a conditional process model. Our findings suggest that emerging language development at 24 months is influenced by the degree of left lateralization of neonatal caudate microstructure, indexed by diffusion tensor imaging (DTI)-derived fractional anisotropy (FA). FA is an indirect measure of neuronal and dendritic density within grey matter structures. We also found that the caudate-language function relationship is partially mediated by cognitive function. The conditional indirect effect of left caudate FA on language composite score through cognitive function was only statistically significant at low levels of home literacy score (-1 standard deviation [SD]). The authors proposed that this may be related to 'compensatory' development of cognitive skills in less favourable home literacy environments.

DOI10.1111/ejn.15347
Alternate JournalEur J Neurosci
PubMed ID34125467