@article{pmid41928498,

title = {Interpersonal Capitalization and Unmet Interpersonal Needs Among Adolescents at Varying Risk for Suicidal Ideation: A Daily Diary Study},

author = {Ignacio Perezmontemayor Cruz and Sasha MacNeil and Johanne Renaud and Jean-Philippe Gouin},

doi = {10.1111/sltb.70096},

issn = {1943-278X},

year  = {2026},

date = {2026-04-01},

journal = {Suicide Life Threat Behav},

volume = {56},

number = {2},

pages = {e70096},

abstract = {INTRODUCTION: Adolescents at risk for suicidal ideation tend to report more unmet interpersonal needs, namely perceived burdensomeness and thwarted belongingness. Interpersonal capitalization-an interpersonal process involving disclosing a positive personal event to others and evaluating others' responsiveness to such disclosure-can promote positive affect and social connectedness. This study examined whether daily capitalization attempts and perceived active-constructive responses to the capitalization attempts were associated with fluctuations in positive affect and unmet interpersonal needs among adolescents at varying risk of suicidal ideation.nnMETHODS: Adolescents (M = 15.55; range = 12-18) with and without major depression, at respectively higher risk (n = 23) and lower risk (n = 32) for suicidal ideation, completed 10 consecutive daily diaries reporting on interpersonal capitalization, positive affect, perceived burdensomeness, and loneliness (as a proxy for thwarted belongingness).nnRESULTS: Within-person hierarchical linear modeling analyses showed that daily capitalization attempts and perceived active-constructive responses were associated with higher same-day positive affect in both groups. In the higher-risk group, daily capitalization attempts were associated with lower same-day perceived burdensomeness (b = -0.102, p < 0.05) and perceived active-constructive responses were related to lower daily loneliness (b = -0.279, p < 0.001).nnCONCLUSION: Daily interpersonal capitalization processes may represent a protective interpersonal pathway linked to reduced suicidal ideation over time, particularly among higher-risk adolescents.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40645654,

title = {Association of hyperactivity-impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study},

author = {Michel Spodenkiewicz and Ayla Inja and Samuele Cortese and Cedric Galera and Isabelle Ouellet-Morin and Sylvana M Côté and Michel Boivin and Frank Vitaro and Mara Brendgen and Ginette Dionne and Johanne Renaud and Richard E Tremblay and Gustavo Turecki and Marie-Claude Geoffroy and Massimilano Orri},

doi = {10.1136/bmjment-2025-301725},

issn = {2755-9734},

year  = {2025},

date = {2025-07-01},

journal = {BMJ Ment Health},

volume = {28},

number = {1},

abstract = {BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptomatology in childhood is associated with a high risk of suicide attempt later in life. However, symptom presentation in ADHD is heterogeneous, and little is known about how suicide risk varies according to different profiles of ADHD symptoms and sex.nnOBJECTIVE: The aim was to investigate the longitudinal associations between childhood profiles of ADHD symptoms (ie, hyperactivity-impulsivity and inattention) and youth suicide attempt in males and females, separately.nnMETHODS: This population-based cohort study used data from three longitudinal cohorts: the Quebec Longitudinal Study of Child Development (QLSCD), the Quebec Longitudinal Study of Kindergarten Children (QLSKC) and the Quebec Newborn Twin Study (QNTS) for a total of 4399 participants (1490 from the QLSCD, 2134 from the QLSKC and 775 from the QNTS; 50% females) followed up from ages 6-23 years. Symptoms of hyperactivity-impulsivity and inattention were assessed by teachers five times from ages 6-12 years. Suicide attempt in adolescence and young adulthood (by age 23) was self-reported. Multitrajectory modelling was used to identify profiles of ADHD symptoms, and regression analysis was used to test their association with suicide attempt, adjusting for childhood socioeconomic and clinical characteristics.nnFINDINGS: We identified four ADHD symptom profiles with distinct associations with suicide attempt for males and females. Compared with those with persistently low symptoms, females with persistently high inattention and hyperactivity-impulsivity (OR: 2.54, CI 1.39 to 4.63) or high inattention and low hyperactivity-impulsivity (OR: 1.81, CI 1.21 to 2.70) were at higher risk of suicide attempt, while, among males, only those with decreasing hyperactivity-impulsivity and inattention over time (OR: 2.23, CI 1.20 to 4.13) were at higher risk of suicide attempt.nnCONCLUSIONS: Risk of suicide attempt in children with ADHD symptoms varies according to both symptom profile and sex, the highest risk being for females with high inattention symptoms (with or without hyperactivity), and males with decreasing symptoms.nnCLINICAL IMPLICATIONS: Taking into account differences in both sex and ADHD symptoms profile may be relevant to more accurately identify and manage suicide risk in individuals with high ADHD symptoms, though caution is needed when generalising our population-based findings to clinical populations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38424142,

title = {Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multidomain task-based fMRI study},

author = {Anthony J Gifuni and Fabricio Pereira and M Mallar Chakravarty and Martin Lepage and Henri W Chase and Marie-Claude Geoffroy and Eric Lacourse and Mary L Phillips and Gustavo Turecki and Johanne Renaud and Fabrice Jollant},

doi = {10.1038/s41380-024-02485-w},

issn = {1476-5578},

year  = {2024},

date = {2024-07-01},

journal = {Mol Psychiatry},

volume = {29},

number = {7},

pages = {2135--2144},

abstract = {The occurrence of suicidal behaviors increases during adolescence. Hypersensitivity to negative social signals and deficits in cognitive control are putative mechanisms of suicidal behaviors, which necessitate confirmation in youths. Multidomain functional neuroimaging could enhance the identification of patients at suicidal risk beyond standard clinical measures. Three groups of adolescents (N = 96; 78% females, age = 11.6-18.1) were included: patients with depressive disorders and previous suicide attempts (SA, n = 29); patient controls with depressive disorders but without any suicide attempt history (PC, n = 35); and healthy controls (HC, n = 32). We scanned participants with 3T-MRI during social inclusion/exclusion (Cyberball Game) and response inhibition (Go-NoGo) tasks. Neural activation was indexed by the blood-oxygenation-level dependent (BOLD) of the hemodynamic response during three conditions in the Cyberball Game ("Control condition", "Social Inclusion", and "Social Exclusion"), and two conditions in Go-NoGo task ("Go" and "NoGo" blocks). ANCOVA-style analysis identified group effects across three whole-brain contrasts: 1) NoGo vs. Go, 2) Social inclusion vs. control condition, 3) Social exclusion vs. control condition. We found that SA had lower activation in the left insula during social inclusion vs. control condition compared to PC and HC. Moreover, SA compared to PC had higher activity in the right middle prefrontal gyrus during social exclusion vs. control condition, and in bilateral precentral gyri during NoGo vs. Go conditions. Task-related behavioral and self-report measures (Self-reported emotional reactivity in the Cyberball Game, response times and number of errors in the Go-NoGo Task) did not discriminate groups. In conclusion, adolescent suicidal behaviors are likely associated with neural alterations related to the processing of social perception and response inhibition. Further research, involving prospective designs and diverse cohorts of patients, is necessary to explore the potential of neuroimaging as a tool in understanding the emergence and progression of suicidal behaviors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37208985,

title = {Respiratory sinus arrhythmia, negative social interactions, and fluctuations in unmet interpersonal needs: A daily diary study},

author = {Sasha MacNeil and Johanne Renaud and Jean-Philippe Gouin},

doi = {10.1111/sltb.12967},

issn = {1943-278X},

year  = {2023},

date = {2023-05-01},

journal = {Suicide Life Threat Behav},

abstract = {INTRODUCTION: This study examined daily fluctuations in the unmet interpersonal needs of thwarted belongingness and perceived burdensomeness in response to daily negative social interactions, as well as the moderating role of respiratory sinus arrhythmia (RSA) across adolescents at lower and higher risk for suicidal ideation.nnMETHODS: Fifty five adolescents with major depressive disorder (MDD, i.e., higher-risk group) and without MDD (i.e., lower-risk group) completed measures of resting RSA, and daily measures of negative social interactions, perceived burdensomeness, and loneliness, as a proxy for thwarted belongingness, for 10 consecutive days. Within-person analyses examined the association between daily negative social interactions and unmet interpersonal needs, and the moderating roles of RSA and higher-risk group status. Between-person analyses also examined the association between RSA and unmet interpersonal needs across groups.nnRESULTS: At the within-person level, participants reported more unmet interpersonal needs on days when they reported more negative social interactions. At the between-person level, higher RSA was associated with decreased loneliness in both groups, and decreased burdensomeness among the higher-risk group.nnCONCLUSIONS: Negative social interactions are associated with daily unmet interpersonal needs. Higher RSA may serve as a protective factor mitigating risk for unmet interpersonal needs, particularly burdensomeness, among adolescents at higher risk for suicidal ideation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38146283,

title = {Symptoms characteristics of personality disorders associated with suicidal ideation and behaviors in a clinical sample of adolescents with a depressive disorder},

author = {Anthony Joseph Gifuni and Michel Spodenkiewicz and Geneviève Laurent and Sasha MacNeil and Fabrice Jollant and Johanne Renaud},

doi = {10.3389/fpsyt.2023.1269744},

issn = {1664-0640},

year  = {2023},

date = {2023-01-01},

journal = {Front Psychiatry},

volume = {14},

pages = {1269744},

abstract = {INTRODUCTION: Pathological personality traits have repeatedly been identified as important risk factors for suicidal ideation and behaviors. Moreover, impulsive-aggressive traits, have shown a consistent association with suicidal behaviors across the lifespan. Adolescence represents a critical period for the emergence of different personality traits, mood disorders, and suicidal behaviors, but the relationship between these variables remain poorly understood.nnMETHODS: These variables were examined in a cross-sectional case-control design involving three groups: 30 adolescents with a depressive disorder and past suicide attempt (Mean Age = 16.2, Females = 26), 38 adolescents with a depressive disorder but without past suicide attempt (Mean age = 16.0, Females = 29), and 34 healthy adolescent controls (Mean age = 15.2, Females = 22). Suicidal ideations were indexed using Suicidal Behavior Questionnaire (SBQ-R), psychiatric disorder assessed using a semi-structured questionnaire (K-SADS-PL), depressive symptoms with the Beck Depressive Inventory (BDI), symptoms characteristics of personality disorders with the Scheduled Clinical Interview for the DSM-IV (SCID-II) screening questionnaire, and impulsivity with the Barratt Impulsivesness Scale (BIS).nnRESULTS: Findings showed that impulsivity ( = 11.0,  < 0.0001) and antisocial symptoms characteristics of personality disorders ( < 0.001, d = 0.70) displayed the most robust association with adolescent suicide attempts. Borderline symptoms characteristics of personality disorders did not discriminate attempters from non-attempters but presented high correlations with suicidal ideation and depression severity. In an item-wise analysis, suicide attempt status was uniquely correlated with symptoms characteristics of an antisocial personality disorder. Suicide attempt status also correlated with non-suicidal self-injury and a chronic feeling of emptiness.nnDISCUSSION: The caveats of this cross-sectional study include the stability of symptoms characteristics of personality disorders in adolescence and the limited sample size. In sum, suicidal behaviors were characteristically correlated with increased impulsivity and antisocial symptoms characteristics of personality disorders, but other symptoms characteristics of personality disorders were relevant to adolescent depression and suicidal ideation. Understanding the emergence of symptoms characteristics of personality disorders and suicidal behaviors in a developmental context can ultimately inform not only the neurobiological origin of suicidal behaviors, but also provide new avenues for early detection and intervention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37900296,

title = {Hard-to-treat or hard-to-catch? Clinical features and therapeutic outcomes of help-seeking foster care youths with mood disorders},

author = {Xavier Benarous and Hélène Lahaye and Hugues Pellerin and Angèle Consoli and David Cohen and Réal Labelle and Johanne Renaud and Priscille Gérardin and Fabienne El-Khoury and Judith van der Waerden and Jean-Marc Guilé},

doi = {10.3389/fpsyt.2023.1211516},

issn = {1664-0640},

year  = {2023},

date = {2023-01-01},

journal = {Front Psychiatry},

volume = {14},

pages = {1211516},

abstract = {INTRODUCTION: The high level of emotional problems in youths placed in foster care contrasts with the limited use of evidence-based treatments. This study aims to better characterize the clinical features and therapeutic outcomes of foster care youths with mood disorders.nnMETHODS: A secondary analysis of data collected in the context of a French-Canadian clinical research network on pediatric mood disorders in four sites was conducted to compare three groups of patients with depressive or bipolar disorder: those without exposure to child welfare intervention (WCWI,  = 181), those who received non-placement psychosocial intervention (NPI,  = 62), and those in placement interventions (PI,  = 41).nnRESULTS: We observed a very high rate of academic problems in patients in the groups NPI/PI compared to those in the WCWI group. Patients in the PI group had more disruptive behavioral disorders (OR = 6.87, 95% CI [3.25-14.52]), trauma-related disorders (OR = 3.78, 95% CI [1.6-8.94]), and any neurodevelopmental disorders (OR = 2.73, 95% CI [1.36-5.49]) compared to the other groups (NPI/WCWI). Among inpatients, the Clinical Global Impression-Improvement scale and the change in the Children Global Assessment Scale during the hospital stay did not differ across the three groups. We observed a higher prescription rate of antipsychotics in the PI group compared to the NPI/WCWI groups, but no significant difference for antidepressants and mood stabilizers.nnDISCUSSION: These findings support the view that, when provided with dedicated support, fostered inpatient youths can improve in a range comparable to other inpatients. Undetected neurodevelopmental disorders and academic problems are likely important contributors of the burden of mood disorders in these youths.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35803116,

title = {Longitudinal associations throughout adolescence: Suicidal ideation, disturbing dreams, and internalizing symptoms},

author = {Mira El-Hourani and Antonio Zadra and Natalie Castellanos-Ryan and Sophie Parent and Johanne Renaud and Jean R Séguin},

doi = {10.1016/j.sleep.2022.06.012},

issn = {1878-5506},

year  = {2022},

date = {2022-10-01},

journal = {Sleep Med},

volume = {98},

pages = {89--97},

abstract = {OBJECTIVE/BACKGROUND: Many studies have reported associations between disturbing dream occurrence and internalizing symptoms in adults, but the extent to which such associations also characterize adolescents remains unknown. The main goal of the present longitudinal study was to evaluate the strength and stability of the associations between disturbing dream frequency, suicidal ideation, and internalizing symptoms from ages 13 to 18.nnMETHODS: Participants (N = 434) drawn from two longitudinal birth cohort studies on child development in the province of Quebec, Canada, completed annual self-reports of disturbing dream frequency, suicidal ideation, and levels of depression and anxiety.nnRESULTS: Two separate cross-lagged panel models for symptoms of depression and anxiety were conducted with both models showing similar results. In early adolescence, high levels of and higher change in disturbing dream frequency were associated with increased odds of reporting later suicidal ideation, whereas in mid to late adolescence, increased odds of reporting suicidal ideation at age 17 was associated with increased disturbing dream frequency at age 18. Across adolescence, increased levels of depression and anxiety were associated with increased odds of reporting later suicidal ideation and increased disturbing dream frequency.nnCONCLUSIONS: These findings support previous literature suggesting that disturbing dream frequency, depression, and anxiety, are risk factors for suicidal ideation throughout adolescence. The present longitudinal study allows for a refinement of our conceptualization of disturbing dream and their relation to suicide and internalizing symptoms throughout adolescence and suggests that the collection of information on disturbing dream and internalizing symptoms during early adolescence may help screen adolescents for suicide risk.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35907406,

title = {Prevalence of suicidal ideation and self-harm behaviours in children aged 12 years and younger: a systematic review and meta-analysis},

author = {Marie-Claude Geoffroy and Samantha Bouchard and Megan Per and Bassam Khoury and Elise Chartrand and Johanne Renaud and Gustavo Turecki and Ian Colman and Massimiliano Orri},

doi = {10.1016/S2215-0366(22)00193-6},

issn = {2215-0374},

year  = {2022},

date = {2022-09-01},

journal = {Lancet Psychiatry},

volume = {9},

number = {9},

pages = {703--714},

abstract = {BACKGROUND: Suicide in children is a pressing public health concern. The increasing number of deaths by suicide and emergency visits for suicidal ideation and self-harm in children might not be fully representative; it is likely that many more children are in distress but do not seek out help. We conducted a systematic review and meta-analysis of existing studies to quantify the prevalence of suicidal ideation and self-harm behaviours among children in the community aged 12 years and younger.nnMETHODS: In this systematic review and meta-analysis, we searched PsycINFO, MEDLINE, and Web of Science via OVID from database inception to Feb 28, 2022, for articles published in French or English that reported estimates of prevalence of suicidal ideation (including suicide planning) and self-harm behaviours (namely, self-harm, suicide attempts, and non-suicidal self-injury) in children aged 12 years and younger. Reference lists were also searched; case studies, qualitative studies, and health-care visit studies were excluded. The outcomes were suicidal ideation, suicide plan or attempts, and self-harm. We used a random-effects model to calculate the overall pooled prevalence of suicidal ideation and self-harm behaviours for all timeframes combined and for ever versus the past 12 months for suicidal ideation. We used the Joanna Briggs Institute Critical Appraisal tool to evaluate the risk of bias in each study. This study is registered with PROSPERO, CRD42020179041.nnFINDINGS: 28 articles, encompassing 30 studies overall, met the inclusion criteria, aggregating findings from 98 044 children (of whom 46 980 [50·5%] were girls and 46 136 [49·5%] were boys; six articles did not report sex or gender) aged 6-12 years. The pooled prevalence estimate was 7·5% (95% CI 5·9-9·6) for suicidal ideation from 28 studies and 2·2% (2·0-2·5) for suicide planning from three studies. The pooled prevalence was 1·4% (0·4-4·7) for self-harm from four studies, 1·3% (1·0-1·9) for suicide attempt from six studies, and 21·9% (6·2-54·5) for non-suicidal self-injury from two studies. The prevalence of suicidal ideation was higher in studies that included child-reported outcomes (10·9% [95% CI 8·1-14·5] for child only and 10·4% [6·8-15·5] for child and parent combined) than for parent-only reported outcomes (4·7% [3·4-6·6]; p=0·0004). The prevalence of suicidal ideation and self-harm behaviours was similar in boys and girls (suicidal ideation, 7·9% [95% CI 5·2-12·0] for boys vs 6·4% [3·7-10·7] for girls; self-harm behaviours, 3·5% [1·6-7·2] for boys vs 3·0% [1·4-6·4%] for girls). Detailed ethnicity data were not available. High heterogeneity was identified across estimates (I>90%), which was not well explained by the characteristics of the studies.nnINTERPRETATION: A high number of children in the general population can experience suicidal ideation and self-harm behaviours, thus underlining the need for more research on childhood suicide, including developmentally appropriate preventive strategies, such as youth-nominated support teams or dialectical behavioural therapy.nnFUNDING: Canada Research Chair in Youth Mental Health and Suicide Prevention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34042491,

title = {Dos and Don'ts in Designing School-Based Awareness Programs for Suicide Prevention},

author = {Luna Grosselli and Kristina Herzog and Robert H Aseltine and Judit Balazs and Vladimir Carli and Jerry Ciffone and Diego De Leo and Christina van der Feltz-Cornelis and Keith Hawton and Ulrich Hegerl and Kairi Kõlves and Stan Kutcher and Lars Mehlum and Thomas Niederkrotenthaler and Mohsen Rezaeian and Johanne Renaud and Barbara Schneider and Ute Lewitzka and Jürgen Hoyer and Susanne Knappe},

doi = {10.1027/0227-5910/a000783},

issn = {2151-2396},

year  = {2022},

date = {2022-07-01},

journal = {Crisis},

volume = {43},

number = {4},

pages = {270--277},

abstract = { Despite the promising evidence for the effectiveness of school-based awareness programs in decreasing the rates of suicidal thoughts and suicide attempts in young people, no guidelines on the targets and methods of safe and effective awareness programs exist.  This study intends to distill recommendations for school-based suicide awareness and prevention programs from experts.  A three-stage Delphi survey was administered to an expert panel between November 2018 and March 2019. A total of 214 items obtained from open-ended questions and the literature were rated in two rounds. Consensus and stability were used as assessment criteria.  The panel consisted of 19 participants in the first and 13 in the third stage. Recommended targets included the reduction of suicide attempts, the enhancement of help-seeking and peer support, as well as the promotion of mental health literacy and life skills. Program evaluation, facilitating access to healthcare, and long-term action plans across multiple levels were among the best strategies for the prevention of adverse effects.  The study is based on opinions of a rather small number of experts.  The promotion of help-seeking and peer support as well as facilitating access to mental health-care utilities appear pivotal for the success of school-based awareness programs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36561636,

title = {Suicidal ideation and behavior in youth in low- and middle-income countries: A brief review of risk factors and implications for prevention},

author = {Johanne Renaud and Sasha Leigh MacNeil and Lakshmi Vijayakumar and Michel Spodenkiewicz and Sylvanne Daniels and David A Brent and Gustavo Turecki},

doi = {10.3389/fpsyt.2022.1044354},

issn = {1664-0640},

year  = {2022},

date = {2022-01-01},

journal = {Front Psychiatry},

volume = {13},

pages = {1044354},

abstract = {Although global rates of suicide have dropped in the last 30 years, youth in low- and middle-income countries (LMICs) continue to be highly represented in suicide statistics yet underrepresented in research. In this review we present the epidemiology of suicide, suicidal ideation, and suicide attempts among youth in LMICs. We also describe population-level (attitudes toward suicide, socioeconomic, and societal factors) and individual-level clinical and psychosocial risk factors, highlighting specific considerations pertaining to youth in LMICs. These specific considerations in risk factors within this population can inform how multi-level prevention strategies may be targeted to meet their specific needs. Prevention and intervention strategies relying on the stepped-care framework focusing on population-, community-, and individual level targets while considering locally- and culturally relevant practices are key in LMICs. In addition, systemic approaches favoring school-based and family-based interventions are important among youth. Cross-culturally adapted multimodal prevention strategies targeting the heterogeneity that exists in healthcare systems, suicide rates, and risk factors in these countries should be accorded a high priority to reduce the burden of suicide among youth in LMICs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32388626,

title = {Decision-making and cognitive control in adolescent suicidal behaviors: a qualitative systematic review of the literature},

author = {Anthony J Gifuni and Lea C Perret and Eric Lacourse and Marie-Claude Geoffroy and Valentin Mbekou and Fabrice Jollant and Johanne Renaud},

doi = {10.1007/s00787-020-01550-3},

issn = {1435-165X},

year  = {2021},

date = {2021-12-01},

journal = {Eur Child Adolesc Psychiatry},

volume = {30},

number = {12},

pages = {1839--1855},

abstract = {Suicide and suicidal behaviors represent a leading cause of morbidity and mortality during adolescence. While several lines of evidence suggest that suicidal behaviors are associated with risky decisions and deficient cognitive control in laboratory tasks in adults, comparatively less is known about adolescents. Here, we systematically reviewed the literature on the association between these neurocognitive variables and adolescent suicidal behaviors. The online search strategy identified 17 neurocognitive studies examining either cognitive control or decision-making processes in adolescents with past suicidal behaviors. Several studies have reported that adolescents with a history of suicidal behaviors present neuropsychological differences in the cognitive control (using Go/NoGo, suicide Stroop Test, continuous performance test, suicide/death Implicit Association Test), and decision-making (Iowa Gambling Task, Cambridge Gambling Task, cost computation, delay discounting, loss aversion tasks) domains. Due to a lack of replication or conflicting findings, our systematic review suggests that no firm conclusion can be drawn as to whether altered decision-making or poor cognitive control contribute to adolescent suicidal behaviors. However, these results collectively suggest that further research is warranted. Limitations included scarcity of longitudinal studies and a lack of homogeneity in study designs, which precluded quantitative analysis. We propose remediating ways to continue neuropsychological investigations of suicide risk in adolescence, which could lead to the identification of novel therapeutic targets and predictive markers, enabling early intervention in suicidal youth.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33961355,

title = {Brain cortical and subcortical morphology in adolescents with depression and a history of suicide attempt},

author = {Anthony J Gifuni and M Mallar Chakravarty and Martin Lepage and Tiffany C Ho and Marie-Claude Geoffroy and Eric Lacourse and Ian H Gotlib and Gustavo Turecki and Johanne Renaud and Fabrice Jollant},

doi = {10.1503/jpn.200198},

issn = {1488-2434},

year  = {2021},

date = {2021-05-01},

journal = {J Psychiatry Neurosci},

volume = {46},

number = {3},

pages = {E347--E357},

abstract = {BACKGROUND: Suicidal behaviours are a major source of mortality and morbidity among adolescents. Given the maturational changes that occur in cortical and subcortical structures during adolescence, we tested whether atypical brain structural measurements were associated with a history of suicide attempt.nnMETHODS: We assessed 3 groups of adolescents (n = 92; 79% female, mean age 15.9 years, range 11.6-18.1 years): patients with a depressive disorder and a history of suicide attempt (n = 28); patient controls, who had a depressive disorder but no history of suicide attempt (n = 34); and healthy controls (n = 30). We derived regional cortical thickness and surface area, and subcortical volumes, from T1-weighted anatomic MRI scans acquired at 3 T.nnRESULTS: We found significant group differences in surface area in the prefrontal, temporal and parietal regions, as well as in the volume of several subcortical nuclei (pFDR ≤ 0.05), but not in cortical thickness. Post hoc analyses indicated that morphological alterations primarily differentiated patients with a history of suicide attempt from healthy controls, but not from patient controls. However, patients with a history of suicide attempt exhibited positive correlations between age and cortical thickness in the temporal cortices and right insula, and between age and right putamen volume (i.e., thicker regional cortex and larger subcortical volumes with age). These correlations were negative in both patient controls and healthy controls (i.e., thinner regional cortex and smaller subcortical volumes).nnLIMITATIONS: Sample sizes, cross-sectional findings and psychiatric heterogeneity were limitations of this study.nnCONCLUSION: Macroscopic structural differences in several brain regions differentiated adolescents with a history of suicide attempt from healthy controls, but not from patient controls. However, adolescents with a history of suicide attempt may present with atypical maturation of specific cortical and subcortical regions that might contribute to the risk of suicidal behaviour.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34358273,

title = {Substance use disorders and suicidality in youth: A systematic review and meta-analysis with a focus on the direction of the association},

author = {Charlie Rioux and Anne-Sophie Huet and Natalie Castellanos-Ryan and Laurianne Fortier and Myriam Le Blanc and Stéphanie Hamaoui and Marie-Claude Geoffroy and Johanne Renaud and Jean R Séguin},

doi = {10.1371/journal.pone.0255799},

issn = {1932-6203},

year  = {2021},

date = {2021-01-01},

journal = {PLoS One},

volume = {16},

number = {8},

pages = {e0255799},

abstract = {BACKGROUND: Reviews and meta-analyses suggest that substance use and suicidality (i.e., suicidal ideations and attempts) are associated in youth, but the direction of this association remains unclear. Theoretically, the secondary psychiatric disorder hypothesis (SPDH) posits that substance use leads to suicidality, while the secondary substance use disorder hypothesis (SSUDH) posits that suicidality leads to substance use. To clarify these associations, this meta-analysis systematically reviewed studies that examined the prospective associations between SUDs and suicidality in youth (age 25 and younger) and compared results according to the direction of the association.nnMETHODS: Web of Science, Embase, PsycINFO, PubMed, Medline and ProQuest Dissertations & Theses Global were searched from inception to March 8, 2020, and 55 effect sizes from 23 samples were included and analyzed using a three-level meta-analysis.nnRESULTS: SUDs significantly predicted subsequent suicidality (OR = 2.16, 95%CI 1.57-2.97), suicidality significantly predicted subsequent SUDs (OR = 2.16, 95%CI 1.53-3.04), and these effect sizes did not differ (p = 0.49).nnCONCLUSIONS: Considering that 65% of reviewed studies only examined the SPDH, this review highlights that more attention should be given to the SSUDH, and that studies should examine bidirectional associations between SUDs and suicidality across time. Clinically, because SUDs and suicidality were found to influence each other, results suggest that mental health and SUDs should ideally be detected and treated early, and that co-occurring disorders should be assessed and treated concomitantly.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32663935,

title = {Cannabis use, depression and suicidal ideation in adolescence: direction of associations in a population based cohort},

author = {Despina Bolanis and Massimiliano Orri and Natalie Castellanos-Ryan and Johanne Renaud and Tina Montreuil and Michel Boivin and Frank Vitaro and Richard E Tremblay and Gustavo Turecki and Sylvana M Côté and Jean R Séguin and Marie-Claude Geoffroy},

doi = {10.1016/j.jad.2020.05.136},

issn = {1573-2517},

year  = {2020},

date = {2020-09-01},

journal = {J Affect Disord},

volume = {274},

pages = {1076--1083},

abstract = {BACKGROUND: To clarify the direction of the association between frequency of cannabis use, depressive symptoms and suicidal ideation from 15 to 20 years using cross-lagged analyses.nnMETHOD: We included 1606 adolescents from the province of Québec followed since 1997 with information on frequency of cannabis use (none/monthly/weekly), depression (defined as being in the top 10% symptoms) and serious suicidal ideation at ages 15, 17 and 20 years.nnRESULTS: The prevalence of weekly cannabis use increased from 7.0% at age 15 years to 15.6% by age 20 years. Adolescents who reported using cannabis weekly at one age were 11 to 15 times more likely to continue using cannabis over time. In longitudinal cross-lagged analyses, weekly cannabis use at age 15 was associated with greater odds (OR=2.19, 95% CI=1.04-4.58) of suicidal ideation two years later. However, other substance use (alcohol, tobacco, other drugs) fully explained this association. Further, depression predicted subsequent weekly cannabis use, even after adjusting for comorbid other substance use (eg, for depression at 15 years predicting cannabis use at 17 years: OR=2.30, 95% CI=1.19-4.43).nnLIMITATIONS: Quantity of cannabis consumed was not measured.nnCONCLUSION: Findings suggest that depressive symptoms in adolescence may represent a risk factor for weekly cannabis consumption, which once initiated is likely to remain chronic. Weekly cannabis use increased risk for suicidal ideation, but not independently from other substance use including alcohol, tobacco and other drugs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32017089,

title = {Cybervictimization in adolescence and its association with subsequent suicidal ideation/attempt beyond face-to-face victimization: a longitudinal population-based study},

author = {Lea C Perret and Massimiliano Orri and Michel Boivin and Isabelle Ouellet-Morin and Anne-Sophie Denault and Sylvana M Côté and Richard E Tremblay and Johanne Renaud and Gustavo Turecki and Marie-Claude Geoffroy},

doi = {10.1111/jcpp.13158},

issn = {1469-7610},

year  = {2020},

date = {2020-08-01},

journal = {J Child Psychol Psychiatry},

volume = {61},

number = {8},

pages = {866--874},

abstract = {BACKGROUND: Cross-sectional associations have been documented between cybervictimization and suicidal risk; however, prospective associations remain unclear.nnMETHODS: Participants were members of the Quebec Longitudinal Study of Child Development (QLSCD), a prospective birth cohort of 2,120 individuals followed from birth (1997/98) to age 17 years (2014/15). Cybervictimization and face-to-face victimization experienced since the beginning of the school year, as well as serious suicidal ideation and/or suicide attempt were self-reported at ages 13, 15 and 17 years.nnRESULTS: In cross-sectional analyses at 13, 15 and 17 years, adolescents cybervictimized at least once had, respectively, 2.3 (95% CI = 1.64-3.19), 4.2 (95% CI = 3.27-5.41) and 3.5 (95% CI = 2.57-4.66) higher odds of suicidal ideation/attempt after adjusting for confounders including face-to-face victimization, prior mental health symptoms and family hardship. Sensitivity analyses suggested that cybervictimization only and both cyber- and face-to-face victimization were associated with a higher risk of suicidal ideation/attempt compared to face-to-face victimization only and no victimization; however, analyses were based on small n. In prospective analyses, cybervictimization was not associated with suicidal ideation/attempt 2 years later after accounting for baseline suicidal ideation/attempt and other confounders. In contrast, face-to-face victimization was associated with suicidal ideation/attempt 2 years later in the fully adjusted model, including cybervictimization.nnCONCLUSIONS: The cross-sectional association between cybervictimization and suicidal ideation/attempt is independent from face-to-face victimization. The absence of a prospective association suggested short-term effects of cybervictimization on suicidal ideation/attempt.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31782164,

title = {Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence},

author = {Massimiliano Orri and Marie-Claude Geoffroy and Gustavo Turecki and Bei Feng and Mara Brendgen and Frank Vitaro and Ginette Dionne and Stephane Paquin and Cedric Galera and Johanne Renaud and Richard E Tremblay and Sylvana M Côté and Michel Boivin},

doi = {10.1111/jcpp.13163},

issn = {1469-7610},

year  = {2020},

date = {2020-06-01},

journal = {J Child Psychol Psychiatry},

volume = {61},

number = {6},

pages = {711--720},

abstract = {BACKGROUND: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood.nnMETHODS: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsive-aggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components.nnRESULTS: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027.nnCONCLUSIONS: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32090743,

title = {Are youths with disruptive mood dysregulation disorder different from youths with major depressive disorder or persistent depressive disorder?},

author = {Xavier Benarous and Johanne Renaud and Jean Jacques Breton and David Cohen and Réal Labelle and Jean-Marc Guilé},

doi = {10.1016/j.jad.2020.01.020},

issn = {1573-2517},

year  = {2020},

date = {2020-03-01},

journal = {J Affect Disord},

volume = {265},

pages = {207--215},

abstract = {BACKGROUND: Although the disruptive mood dysregulation disorder (DMDD) was included in the depressive disorders (DD) section of the DSM-5, common and distinctive features between DMDD and the pre-existing DD (i.e., major depressive disorder, MDD, and persistent depressive disorder, PDD) received little scrutiny.nnMETHODS: Youths consecutively assessed as outpatients at two Canadian mood clinics over four years were included in the study (n = 163; mean age:13.4 ± 0.3; range:7-17). After controlling for inter-rater agreement, data were extracted from medical charts, using previously validated chart-review instruments.nnRESULTS: Twenty-two percent of youths were diagnosed with DMDD (compared to 36% for MDD and 25% for PDD), with substantial overlap between the three disorders. Youths with DMDD were more likely to have a comorbid non-depressive psychiatric disorder - particularly attention deficit hyperactivity disorder, odds ratio (OR=3.9), disruptive, impulse-control and conduct disorder (OR=3.0) or trauma- and stressor-related disorder (OR=2.5). Youths with DMDD did not differ with regard to the level of global functioning, but reported more school and peer-relationship difficulties compared to MDD and/or PDD. The vulnerability factors associated with mood disorders (i.e., history of parental depression and adverse life events) were found at a comparable frequency across the three groups.nnLIMITATIONS: The retrospective design and the selection bias for mood disordered patients restricted the generalizability of the results.nnCONCLUSIONS: Youths with DMDD share several clinical features with youths with MDD and PDD. Further studies are required to determine the developmental trajectories and the benefits of expanding pharmacotherapy for DD to DMDD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31956339,

title = {Are school difficulties an early sign for mental disorder diagnosis and suicide prevention? A comparative study of individuals who died by suicide and control group},

author = {Fabienne Ligier and Charles-Edouard Giguère and Charles-Edouard Notredame and Alain Lesage and Johanne Renaud and Monique Séguin},

doi = {10.1186/s13034-019-0308-x},

issn = {1753-2000},

year  = {2020},

date = {2020-01-01},

journal = {Child Adolesc Psychiatry Ment Health},

volume = {14},

pages = {1},

abstract = {BACKGROUND: Suicide is the third leading cause of death worldwide among youth aged 10- to 19, and mental disorders are often associated in the etiology of suicidal behavior. Mental disorders are often under-diagnosed and under-treated in young people, a situation likely to increase the severity of the disorder and suicide risk. Presence of school difficulties may, in some cases, be a consequence of mental disorder, and theses difficulties are observable. Therefore, early detection and early intervention of school difficulties may alleviate the development of mental disorders and suicide vulnerability. The aim of this study is to understand the link between school difficulties and suicide risk.nnMETHODS: We used the data bank gathered by the McGill Group on Suicide Studies over the past two decades through interviews with the relatives of individuals who died by suicide and with individuals from the community as a control group. We included data on common sociodemographic characteristics, life events and mental health characteristics identified before age 18, among individuals who died before the age of 35 or were interviewed before the age of 35. We identified 200 individuals who died by suicide and 97 living controls. We compared groups according to gender and characteristics.nnRESULTS: Within the total sample, 74% were male, 13% had met with academic failure, 18% had engaged in inappropriate behavior at school, and 18% presented combined school difficulties. Combined school difficulties (academic failure and inappropriate behavior) for both sexes and academic failure alone for males were associated with higher suicide risk before the age of 35. School difficulties generally began in early childhood and were linked to mental disorders/difficulties and substance abuse before age 18.nnCONCLUSIONS: This study underlines the importance for parents, teachers, and educators to identify children with school difficulties-academic failure and behavioral difficulties at school-as early as possible in order to be able to propose adapted interventions. Early identification and proper diagnosis may prevent chronicity of some disorders, accumulation of adverse events, and even suicide.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid30293122,

title = {Suicidal behaviors and irritability in children and adolescents: a systematic review of the nature and mechanisms of the association},

author = {Xavier Benarous and Angèle Consoli and David Cohen and Johanne Renaud and Hélène Lahaye and Jean-Marc Guilé},

doi = {10.1007/s00787-018-1234-9},

issn = {1435-165X},

year  = {2019},

date = {2019-05-01},

journal = {Eur Child Adolesc Psychiatry},

volume = {28},

number = {5},

pages = {667--683},

abstract = {While many psychiatric disorders are associated with an increased risk for suicidal behaviors (SB) in children and adolescents, a few studies have explored the role of clinical symptoms based on a dimensional approach. Irritability is seen as a marker, a general psychopathology, and a symptom of both externalizing and internalizing disorders. In this review, we are interested in determining whether and how irritability can predict SB in youth. First, we reviewed consistencies and variation in the literature linking irritability to suicidal ideation (SI) and suicide attempt (SA). Second, based on the available models, we proposed specific mechanistic pathways, whereby irritability may modulate the risk for SB. Irritability has been found associated with SB both in cross-sectional and in longitudinal studies. The relation is consistent in different settings (i.e., general population and clinical settings) and across psychiatric disorders. The association is reduced but persists after adjusting for psychiatric disorder, including depression. On one hand, irritability constitutes a risk factor for SI via the onset of internalized disorder. On the other hand, irritable youth may be more prone to attempt suicide when experiencing SI. The measures for irritability were heterogeneous. A limited number of studies were designed to explore the role of mediators and/or moderators. Recognizing irritability in children and adolescents is a key issue with regards to suicide prevention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}