Jamie Near | The Douglas Research Centre

Jamie Near
PhD

Division:
Basic Neuroscience

Jamie Near, PhD

jamie.near@mcgill.ca

http://www.github.com/CIC-methods/FID-A

Associated Researcher, Douglas Research Centre

Research Summary

Jamie Near's research is focused on the development of advanced magnetic resonance spectroscopy (MRS) techniques to accurately measure metabolite concentrations in the human brain. Specific activities in Jamie Near's Laboratory include:

Pulse sequence programming
Data processing and analysis
Radiofrequency coil development
Quantum mechanical simulation of MRS experiments

Bio

A native of Toronto, Jamie Near received his undergraduate degree in Engineering Physics from Queen's University in 2004. He then went on to the University of Western Ontario's Robarts Research Institute where he received his PhD in Medical Biophysics. His doctoral thesis involved the development of imaging techniques and radiofrequency coils for MR investigations of prostate cancer. Following his PhD, Jamie then went on to a postdoctoral position at the University of Oxford, UK, where his research was focused on the development of magnetic resonance spectroscopy (MRS) methods for quantitative measurement of neurotransmitter concentrations in the human brain, with a particular focus on psychiatric applications. In 2012, Jamie returned to Canada to work as an Assistant Professor in the Department of Psychiatry at McGill University.

Recent news

2019-12-09
Caitlin Fowler, featured in the latest "Trainee Spotlight"

Caitlin Fowler

Recent publications

Fowler C, Goerzen D, Madularu D, Devenyi GA, Chakravarty MM, Near J. Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes. Neurobiol Aging. 2022;109:216-228.
- PubMed
- RIS
Takado Y, Takuwa H, Sampei K, Urushihata T, Takahashi M, Shimojo M, et al. MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice. J Cereb Blood Flow Metab. 2022;42(1):197-212.
- PubMed
- RIS
Dehghani M, Edden R, Near J. Hadamard-encoded dual-voxel SPECIAL: Short-TE MRS acquired in two brain regions simultaneously using Hadamard encoding. Magn Reson Med. 2021.
- PubMed
- RIS
Hui SC, Mikkelsen M, Zöllner HJ, Ahluwalia V, Alcauter S, Baltusis L, et al. Frequency drift in MR spectroscopy at 3T. Neuroimage. 2021;241:118430.
- PubMed
- RIS
Plitman E, Bussy A, Valiquette V, Salaciak A, Patel R, Cupo L, et al. The impact of the Siemens Tim Trio to Prisma upgrade and the addition of volumetric navigators on cortical thickness, structure volume, and H-MRS indices: An MRI reliability study with implications for longitudinal study designs. Neuroimage. 2021;238:118172.
- PubMed
- RIS
Fowler CF, Madularu D, Dehghani M, Devenyi GA, Near J. Longitudinal quantification of metabolites and macromolecules reveals age- and sex-related changes in the healthy Fischer 344 rat brain. Neurobiol Aging. 2021;101:109-122.
- PubMed
- RIS
Lin A, Andronesi O, Bogner W, Choi I-, Coello E, Cudalbu C, et al. Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations. NMR Biomed. 2021;34(5):e4484.
- PubMed
- RIS
van Vugt FT, Near J, Hennessy TJ, Doyon J, Ostry DJ. Early stages of sensorimotor map acquisition: neurochemical signature in primary motor cortex and its relation to functional connectivity. J Neurophysiol. 2020.
- PubMed
- RIS
Kreis R, Boer V, Choi I-, Cudalbu C, de Graaf RA, Gasparovic C, et al. Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations. NMR Biomed. 2020:e4347.
- PubMed
- RIS
Mikkelsen M, Tapper S, Near J, Mostofsky SH, Puts NA, Edden RA. Correcting frequency and phase offsets in MRS data using robust spectral registration. NMR Biomed. 2020;33(10):e4368.
- PubMed
- RIS
Goerzen D, Fowler C, Devenyi GA, Germann J, Madularu D, Chakravarty MM, et al. An MRI-Derived Neuroanatomical Atlas of the Fischer 344 Rat Brain. Sci Rep. 2020;10(1):6952.
- PubMed
- RIS
Near J, Harris AD, Juchem C, Kreis R, Marjańska M, Öz G, et al. Preprocessing, analysis and quantification in single-voxel magnetic resonance spectroscopy: experts' consensus recommendations. NMR in BiomedicineNMR in BiomedicineNMR in Biomedicine. 2020;n/a(n/a):e4257.
- RIS
Motegi T, Narita K, Fujihara K, Kasagi M, Suzuki Y, Tagawa M, et al. Glutamine + glutamate level predicts the magnitude of microstructural organization in the gray matter in the healthy elderly. Int Psychogeriatr. 2019:1-9.
- PubMed
- RIS
Takado Y, Sato N, Kanbe Y, Tomiyasu M, Xin L, Near J, et al. Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS. Nutrients. 2019;11(7).
- PubMed
- RIS
Plitman E, Guma E, Lepage M, Near J, Chakravarty MM. Using proton magnetic resonance spectroscopic imaging to study glutamatergic alterations in patients with schizophrenia: A systematic review. Schizophr Res. 2019;210:13-20.
- PubMed
- RIS
Knudsen MK, Near J, Blicher AB, Videbech P, Blicher JU. Magnetic resonance (MR) spectroscopic measurement of γ-aminobutyric acid (GABA) in major depression before and after electroconvulsive therapy. Acta Neuropsychiatr. 2018:1-10.
- PubMed
- RIS
S Wijtenburg A, Near J, Korenic SA, Gaston FE, Chen H, Mikkelsen M, et al. Comparing the reproducibility of commonly used magnetic resonance spectroscopy techniques to quantify cerebral glutathione. J Magn Reson Imaging. 2018.
- PubMed
- RIS
Kumaragamage C, Madularu D, Mathieu AP, Lupinsky D, de Graaf RA, Near J. Minimum echo time PRESS-based proton observed carbon edited (POCE) MRS in rat brain using simultaneous editing and localization pulses. Magn Reson Med. 2018.
- PubMed
- RIS
Mikkelsen M, Saleh MG, Near J, Chan KL, Gong T, Harris AD, et al. Frequency and phase correction for multiplexed edited MRS of GABA and glutathione. Magn Reson Med. 2018;80(1):21-28.
- PubMed
- RIS
Madularu D, Mathieu AP, Kumaragamage C, Reynolds LM, Near J, Flores C, et al. A non-invasive restraining system for awake mouse imaging. J Neurosci Methods. 2017;287:53-57.
- PubMed
- RIS
Kumaragamage C, Madularu D, Mathieu AP, De Feyter H, Maria Rajah N, Near J. In vivo proton observed carbon edited (POCE) (13) C magnetic resonance spectroscopy of the rat brain using a volumetric transmitter and receive-only surface coil on the proton channel. Magn Reson Med. 2017.
- PubMed
- RIS
Madularu D, Kumaragamage C, Mathieu AP, Kulkarni P, Maria Rajah N, Gratton A, et al. A chronic in situ coil system adapted for intracerebral stimulation during MRI in rats. J Neurosci Methods. 2017;284:85-95.
- PubMed
- RIS
Papoutsis K, Li L, Near J, Payne S, Jezzard P. A purpose-built neck coil for black-blood DANTE-prepared carotid artery imaging at 7T. Magn Reson Imaging. 2017;40:53-61.
- PubMed
- RIS
Suri S, Emir U, Stagg CJ, Near J, Mekle R, Schubert F, et al. Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex. Neuroimage. 2017;152:509-516.
- PubMed
- RIS
Kanaan AS, Gerasch S, García-García I, Lampe L, Pampel A, Anwander A, et al. Pathological glutamatergic neurotransmission in Gilles de la Tourette syndrome. Brain. 2017;140(Pt 1):218-234.
- PubMed
- RIS