Jacques Tremblay MD, MSc, BA
6875 Boulevard LaSalle
Researcher, Douglas Research Centre
General Practitioner, Department of Psychiatry, Douglas Mental Health University Institute
Councilior, Council of physicians, dentists, and pharmacists, CIUSSS ODIM
Assistant Professor, Department of Psychiatry, McGill University
General Practitioner, Departments of Psychiatry and General Medicine, CIUSSS de l'Outaouais
Clinical epidemiology in mental health
-Introduction of the concept of quality of medical care assessment using explicit and implicit criteria in Canada, following the world first clinical trial of Drug Use Review (DUR), conducted under US funding (Grant HS-03971), in the eighties. This concept is now used widely in North America, for purposes of institutional certification, and is the main quality of care assessment method used, and recommended by the Quebec College of Physicians.
-Participation in several clinical studies on substance abusers and their treatment, with a randomized clinical trial (RCT) of aftercare treatment for the multiple substances abuser. This contributed to externally validate evidence for the effectiveness of behavioural cognitive and AA-oriented group therapy. This researcher was responsible for original trial design. These studies have succeeded to lay a foundation for evidence-based practice in this area of the addictions. (1992 - 2003).
-Analysis of population survey data from Quechua Indians in Peru, measuring the long-term effects of protracted political violence on mental health. This research documented local idioms of distress using an ethnographic approach, and integrated a trauma questionnaire to measures of anxiety and depression, this researcher modeling the relationship between the degree of exposure to protracted violence, migratory status, and mental health variables (2001-2009).
-Participation in the development of indicators, from psychosocial, biological, and demographic dimensions, to predict recidivism of Driving under the Influence of Alcohol (DUI). This researcher was responsible for the biological dimension of this indicator development. Identification of cortisol reactivity as best predictor of DUI recidivism, in collaboration. Participation in the development and conduct of a RCT to test the effectiveness of Brief Motivational Interviewing among DUI recidivists, and impact of sleep deprivation and alcohol on young driver performance (2002+).
-Participation in a number of studies on the role of psychiatrists and general practitioners in mental health practice, and in the assessment of patient need severity following the implementation of the Quebec Mental Health Action Plan, from the patient perspective. This researcher is co-directed the later, under CIHR funding (2003+).
-Participation in a research team dedicated to the development of an epidemiological catchment area in the South-West of Montreal, in the area of mental health. This researcher contributed in the area of substance abuse and clinical medicine, and acted as medical officer for diagnostic divulgation, and for referral to appropriate services (2006+).
-Participation in the design and conduct of several RCT to assess the effectiveness of reconsolidation blockade (RB) for the emotional component of traumatic memories under medication in Post-Traumatic Stress Disorder (PTSD). Participation in an international research group including the American VA, Toulouse and Harvard Universities, to test the effectiveness of various medications in RB for PTSD patients, and in animal models using behavioural and neuro-chemical models. This researcher acted as medical officer for the conduct of Canadian trials of propranolol, to test RB effectiveness in PTSD, and drug craving (2007+).
Brown, T.G., Seraganian, P., Tremblay, J. & Annis, H. (2002). Process and outcome changes with relapse prevention versus 12-Step aftercare programs for substance abusers. Addiction, 97, 677-689.
Brunet, J., Orr, S., Tremblay, J., Robertson, K., Nader, K. & Pitman, R.K. (2008). Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. Journal of Psychiatric Research, 42(6), 503-506.
Lasry, N., Levy, E. & Tremblay, J. (2008). Making Memories, Again. A Comment on: J.D. Karpicke & H.L. Roediger III. The Critical Importance of Retrieval for Learning. Science 2008; 319: 966-968. Science, 320(5884), 1720.
Tremblay, J., Pedersen, D. & Errazuriz, C. (2009). Assessing mental health outcomes of political violence and civil unrest in Peru. International Journal of Social Psychiatry, 55(5), 449-63.
Brown, T.G., Dongier, M., Ouimet, M.C., Tremblay, J., Chanut, F., Legault, L. & Ng Ying Kin, N.M.K. (2010). Brief Motivational Interviewing for DWI recidivists who abuse alcohol and are not participating in DWI intervention: a randomized controlled trial. Alcoholism: Clinical and Experimental Research, 34(2), 1-10.
Brunet, A., Poundja, J., Tremblay, J., Bui, E., Thomas, E., Orr, S.P., Azzoug, A., Birmes, P. & Pitman, R.K. (2011). Trauma Reactivation under the Influence of Propranolol Decreases Posttraumatic Stress Symptoms and Disorder: 3 Open-Label Trials. Journal of Clinical Psychopharmacology, 31(4), 547-550.
Caron, J., Fleury, M.J., Perreault, M., Crocker, A., Tremblay, J., Tousignant, M., Kestens, Y., Cargo, M. & Daniel, M. (2012). Prevalence of psychological distress and mental disorders, and use of mental health services in the epidemiological catchment area of Montreal South-West. BMC Psychiatry, 12, 183 - DOI: 10.1186/1471-244X-12-183.
Ouimet, M.C., Dongier, M., Di Leo, I., Legault, L., Tremblay, J., Chanut, F. & Brown, T.G. (2013). A Randomized Controlled Trial of Brief Motivational Interviewing in Impaired Driving Recidivists: A 5-Year Follow-Up of Traffic Offenses and Crashes. Alcoholism Clinical & Experimental Research, 37(11), 1979-85 - DOI: 10.1111/acer.12180.
Tremblay, J, Bamvita, J.M., Grenier, G., Fleury, M.J. (2014). Utility of the Montreal Assessment of Need Questionnaire for Community Mental Health Planning. Journal of Nervous and Mental Disease, 202(9):677-687.
Couture, S., Ouimet, M.C., Gianoulakis, C., Tremblay, J., Ng, Ying Kin N., Brochu, S., Pruessner, J., Dedovic, K. & Brown, T.G. (2015). Lower Cortisol Activity is Associated with First-Time Driving while Impaired. Substance Abuse : Research and Treatment, 9:25-32. doi: 10.4137/SART.S21353.
Reduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy: A Randomized Controlled Trial. Am J Psychiatry. 2018:appiajp201717050481.
Consolidation and reconsolidation are impaired by oral propranolol administered before but not after memory (re)activation in humans. Neurobiol Learn Mem. 2017;142(Pt A):118-125.