Intravenous arketamine for treatment-resistant depression: open-label pilot study.

TitleIntravenous arketamine for treatment-resistant depression: open-label pilot study.
Publication TypeJournal Article
Year of Publication2020
AuthorsLeal GC, Bandeira ID, Correia-Melo FS, Telles M, Mello RP, Vieira F, Lima CS, Jesus-Nunes APaula, Guerreiro-Costa LNF, Marback RF, Caliman-Fontes ATeresa, Marques BLS, Bezerra MLO, Dias-Neto AL, Silva SS, Sampaio AS, Sanacora G, Turecki G, Loo C, Lacerda ALT, Quarantini LC
JournalEur Arch Psychiatry Clin Neurosci
Date Published2020 Feb 20
ISSN1433-8491
Abstract

We aimed to analyze the efficacy and safety of arketamine, the R(-)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery-Åsberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion to 10.4 after one day, a mean difference of 20.3 points [CI 95% 13.6-27.0; p < 0.001]; dissociation was nearly absent. Arketamine might produce fast-onset and sustained antidepressant effects in humans with favorable safety profile, like previously reported with animals; further controlled-trials are needed.

DOI10.1007/s00406-020-01110-5
Alternate JournalEur Arch Psychiatry Clin Neurosci
PubMed ID32078034
Grant List003/2017 / / Programa de Pesquisa para o SUS /