Interneuron activity leads to initiation of low-voltage fast-onset seizures.
|Title||Interneuron activity leads to initiation of low-voltage fast-onset seizures.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Shiri Z, Manseau F, Lévesque M, Williams S, Avoli M|
|Date Published||2015 Mar|
Seizures in temporal lobe epilepsy can be classified as hypersynchronous and low-voltage fast according to their onset patterns. Experimental evidence suggests that low-voltage fast-onset seizures mainly result from the synchronous activity of γ-aminobutyric acid-releasing cells. In this study, we tested this hypothesis using the optogenetic control of parvalbumin-positive interneurons in the entorhinal cortex, in the in vitro 4-aminopyridine model. We found that both spontaneous and optogenetically induced seizures had similar low-voltage fast-onset patterns. In addition, both types of seizures presented with higher ripple than fast ripple rates. Our data demonstrate the involvement of interneuronal networks in the initiation of low-voltage fast-onset seizures.
|Alternate Journal||Ann. Neurol.|
|PubMed Central ID||PMC4880461|
|Grant List||74609 / / Canadian Institutes of Health Research / Canada |
8109 / / Canadian Institutes of Health Research / Canada
MOP119340 / / Canadian Institutes of Health Research / Canada