Hippocampal subfield volumes across the healthy lifespan and the effects of MR sequence on estimates.

TitleHippocampal subfield volumes across the healthy lifespan and the effects of MR sequence on estimates.
Publication TypeJournal Article
Year of Publication2021
AuthorsBussy A, Plitman E, Patel R, Tullo S, Salaciak A, Bedford SA, Farzin S, Béland M-L, Valiquette V, Kazazian C, Tardif CLucas, Devenyi GA, Chakravarty MM
Corporate AuthorsAlzheimer's Disease Neuroimaging Initiative
JournalNeuroimage
Volume233
Pagination117931
Date Published2021 06
ISSN1095-9572
KeywordsAged, Aged, 80 and over, Cross-Sectional Studies, Databases, Factual, Female, Healthy Aging, Hippocampus, Humans, Longevity, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size
Abstract

The hippocampus has been extensively studied in various neuropsychiatric disorders throughout the lifespan. However, inconsistent results have been reported with respect to which subfield volumes are most related to age. Here, we investigate whether these discrepancies may be explained by experimental design differences that exist between studies. Multiple datasets were used to collect 1690 magnetic resonance scans from healthy individuals aged 18-95 years old. Standard T1-weighted (T1w; MPRAGE sequence, 1 mm voxels), high-resolution T2-weighted (T2w; SPACE sequence, 0.64 mm voxels) and slab T2-weighted (Slab; 2D turbo spin echo, 0.4 × 0.4 × 2 mm voxels) images were included. The MAGeT Brain algorithm was used for segmentation of the hippocampal grey matter (GM) subfields and peri-hippocampal white matter (WM) subregions. Linear mixed-effect models and Akaike information criterion were used to examine linear, second or third order natural splines relationship between hippocampal volumes and age. We demonstrated that stratum radiatum/lacunosum/moleculare and fornix subregions expressed the highest relative volumetric decrease, while the cornus ammonis 1 presented a relative volumetric preservation of its volume with age. We also found that volumes extracted from slab images demonstrated different age-related relationships compared to volumes extracted from T1w and T2w images. The current work suggests that although T1w, T2w and slab derived subfield volumetric outputs are largely homologous, modality choice plays a meaningful role in the volumetric estimation of the hippocampal subfields.

DOI10.1016/j.neuroimage.2021.117931
Alternate JournalNeuroimage
PubMed ID33677075
Grant List / / CIHR / Canada
U01 AG024904 / AG / NIA NIH HHS / United States
BB/H008217/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
/ MRC_ / Medical Research Council / United Kingdom