Hippocampal (subfield) volume and shape in relation to cognitive performance across the adult lifespan.

TitleHippocampal (subfield) volume and shape in relation to cognitive performance across the adult lifespan.
Publication TypeJournal Article
Year of Publication2015
AuthorsVoineskos AN, Winterburn JL, Felsky D, Pipitone J, Rajji TK, Mulsant BH, M Chakravarty M
JournalHum Brain Mapp
Volume36
Issue8
Pagination3020-37
Date Published2015 Aug
ISSN1097-0193
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Aging, Apolipoprotein E4, Atlases as Topic, Cognition, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Organ Size, Young Adult
Abstract

Newer approaches to characterizing hippocampal morphology can provide novel insights regarding cognitive function across the lifespan. We comprehensively assessed the relationships among age, hippocampal morphology, and hippocampal-dependent cognitive function in 137 healthy individuals across the adult lifespan (18-86 years of age). They underwent MRI, cognitive assessments and genotyping for Apolipoprotein E status. We measured hippocampal subfield volumes using a new multiatlas segmentation tool (MAGeT-Brain) and assessed vertex-wise (inward and outward displacements) and global surface-based descriptions of hippocampus morphology. We examined the effects of age on hippocampal morphology, as well as the relationship among age, hippocampal morphology, and episodic and working memory performance. Age and volume were modestly correlated across hippocampal subfields. Significant patterns of inward and outward displacement in hippocampal head and tail were associated with age. The first principal shape component of the left hippocampus, characterized by a lengthening of the antero-posterior axis was prominently associated with working memory performance across the adult lifespan. In contrast, no significant relationships were found among subfield volumes and cognitive performance. Our findings demonstrate that hippocampal shape plays a unique and important role in hippocampal-dependent cognitive aging across the adult lifespan, meriting consideration as a biomarker in strategies targeting the delay of cognitive aging.

DOI10.1002/hbm.22825
Alternate JournalHum Brain Mapp
PubMed ID25959503
Grant ListR01MH099167 / MH / NIMH NIH HHS / United States
R01MH102324 / MH / NIMH NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada

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