Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease.

TitleHippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease.
Publication TypeJournal Article
Year of Publication2019
AuthorsFontes K, Rohlicek CV, Saint-Martin C, Gilbert G, Easson K, Majnemer A, Marelli A, M Chakravarty M, Brossard-Racine M
JournalHum Brain Mapp
Volume40
Issue12
Pagination3548-3560
Date Published2019 Aug 15
ISSN1097-0193
Abstract

There is a high prevalence of neurodevelopmental impairments in individuals living with congenital heart disease (CHD) and the neural correlates of these impairments are not yet fully understood. Recent studies have shown that hippocampal volume and shape differences may provide unique biomarkers for neurodevelopmental disorders. The hippocampus is vulnerable to early life injury, especially in populations at risk for hypoxemia or hemodynamic instability such as in neonates with CHD. We compared hippocampal gray and white matter volume and morphometry between youth born with CHD (n = 50) aged 16-24 years and healthy peers (n = 48). We also explored whether hippocampal gray and white matter volume and morphometry are associated with executive function and self-regulation deficits. To do so, participants underwent 3T brain magnetic resonance imaging and completed the self-reported Behavior Rating Inventory of Executive Function-Adult version. We found that youth with CHD had smaller hippocampal volumes (all statistics corrected for false discovery rate; q < 0.05) as compared to controls. We also observed significant smaller surface area bilaterally and inward displacement on the left hippocampus predominantly on the ventral side (q < 0.10) in the CHD group that were not present in the controls. Left CA1 and CA2/3 were negatively associated with working memory (p < .05). Here, we report, for the first-time, hippocampal morphometric alterations in youth born with CHD when compared to healthy peers, as well as, structure-function relationships between hippocampal volumes and executive function. These differences may reflect long lasting alterations in brain development specific to individual with CHD.

DOI10.1002/hbm.24615
Alternate JournalHum Brain Mapp
PubMed ID31070841
Grant List / / Faculty of Medicine, McGill University /
/ / Research Institute of the McGill University Health Centre, Montreal Children's Hospital Foundation /