HIF3A association with adiposity: the story begins before birth.

TitleHIF3A association with adiposity: the story begins before birth.
Publication TypeJournal Article
Year of Publication2015
AuthorsPan H, Lin X, Wu Y, Chen L, Teh ALing, Soh SE, Lee YSeng, Tint MThway, MacIsaac JL, Morin AM, Tan KHian, Yap F, Saw SMei, Kobor MS, Meaney MJ, Godfrey KM, Chong Y-S, Gluckman PD, Karnani N, Holbrook JD
Corporate Authorsgroup Gstudy
JournalEpigenomics
Volume7
Issue6
Pagination937-50
Date Published2015
ISSN1750-192X
KeywordsAdiposity, Adult, Alleles, Basic Helix-Loop-Helix Transcription Factors, Birth Weight, Child, Preschool, CpG Islands, DNA Methylation, Environmental Exposure, Epigenesis, Genetic, Female, Gene Expression Regulation, Genotype, Humans, Infant, Infant, Newborn, Male, Maternal Exposure, Polymorphism, Single Nucleotide, Pregnancy, Umbilical Cord
Abstract

AIM: Determine if the association of HIF3A DNA methylation with weight and adiposity is detectable early in life.MATERIAL & METHODS: We determined HIF3A genotype and DNA methylation patterns (on hybridization arrays) in DNA extracted from umbilical cords of 991 infants. Methylation levels at three CpGs in the HIF3A first intron were related to neonatal and infant anthropometry and to genotype at nearby polymorphic sites.RESULTS & CONCLUSION: Higher methylation levels at three previously described HIF3A CpGs were associated with greater infant weight and adiposity. The effect sizes were slightly smaller than those reported for adult BMI. There was also an interaction within cis-genotype. The association between higher DNA methylation at HIF3A and increased adiposity is present in neonates. In this study, no particular prenatal factor strongly influenced HIF3A hypermethylation. Our data nonetheless suggest shared prenatal influences on HIF3A methylation and adiposity.

DOI10.2217/epi.15.45
Alternate JournalEpigenomics
PubMed ID26011824
PubMed Central IDPMC4863876
Grant ListMC_UP_A620_1017 / / Medical Research Council / United Kingdom
MC_UU_12011/4 / / Medical Research Council / United Kingdom