Head direction is coded more strongly than movement direction in a population of entorhinal neurons.

TitleHead direction is coded more strongly than movement direction in a population of entorhinal neurons.
Publication TypeJournal Article
Year of Publication2015
AuthorsRaudies F, Brandon MP, G Chapman W, Hasselmo ME
JournalBrain Res
Volume1621
Pagination355-67
Date Published2015 Sep 24
ISSN1872-6240
Abstract

The spatial firing pattern of entorhinal grid cells may be important for navigation. Many different computational models of grid cell firing use path integration based on movement direction and the associated movement speed to drive grid cells. However, the response of neurons to movement direction has rarely been tested, in contrast to multiple studies showing responses of neurons to head direction. Here, we analyzed the difference between head direction and movement direction during rat movement and analyzed cells recorded from entorhinal cortex for their tuning to movement direction. During foraging behavior, movement direction differs significantly from head direction. The analysis of neuron responses shows that only 5 out of 758 medial entorhinal cells show significant coding for both movement direction and head direction when evaluating periods of rat behavior with speeds above 10 cm/s and ±30° angular difference between movement and head direction. None of the cells coded movement direction alone. In contrast, 21 cells in this population coded only head direction during behavioral epochs with these constraints, indicating much stronger coding of head direction in this population. This suggests that the movement direction signal required by most grid cell models may arise from other brain structures than the medial entorhinal cortex. This article is part of a Special Issue entitled SI: Brain and Memory.

DOI10.1016/j.brainres.2014.10.053
Alternate JournalBrain Res.
PubMed ID25451111
PubMed Central IDPMC4427560
Grant ListMH61492 / MH / NIMH NIH HHS / United States
P50 MH094263 / MH / NIMH NIH HHS / United States
R01 MH060013 / MH / NIMH NIH HHS / United States
R01 MH061492 / MH / NIMH NIH HHS / United States
R01 MH60013 / MH / NIMH NIH HHS / United States