A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?

TitleA harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?
Publication TypeJournal Article
Year of Publication2017
AuthorsWisse LEM, Daugherty AM, Olsen RK, Berron D, Carr VA, Stark CEL, Amaral RSC, Amunts K, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren A, M Chakravarty M, Chupin M, Ekstrom A, de Flores R, Insausti R, Kanel P, Kedo O, Kennedy KM, Kerchner GA, LaRocque KF, Liu X, Maass A, Malykhin N, Mueller SG, Ofen N, Palombo DJ, Parekh MB, Pluta JB, Pruessner JC, Raz N, Rodrigue KM, Schoemaker D, Shafer AT, Steve TA, Suthana N, Wang L, Winterburn JL, Yassa MA, Yushkevich PA, La Joie R
Corporate AuthorsHippocampal Subfields Group
JournalHippocampus
Volume27
Issue1
Pagination3-11
Date Published2017 Jan
ISSN1098-1063
Abstract

The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, the Hippocampal Subfields Group was formed as an international collaboration with the aim of developing a harmonized protocol for manual segmentation of hippocampal and parahippocampal subregions on high-resolution MRI. In this commentary we discuss the goals for this protocol and the associated key challenges involved in its development. These include differences among existing anatomical reference materials, striking the right balance between reliability of measurements and anatomical validity, and the development of a versatile protocol that can be adopted for the study of populations varying in age and health. The commentary outlines these key challenges, as well as the proposed solution of each, with concrete examples from our working plan. Finally, with two examples, we illustrate how the harmonized protocol, once completed, is expected to impact the field by producing measurements that are quantitatively comparable across labs and by facilitating the synthesis of findings across different studies. © 2016 Wiley Periodicals, Inc.

DOI10.1002/hipo.22671
Alternate JournalHippocampus
PubMed ID27862600
PubMed Central IDPMC5167633
Grant ListK01 DA034728 / DA / NIDA NIH HHS / United States
P50 AG005146 / AG / NIA NIH HHS / United States
R03 NS093052 / NS / NINDS NIH HHS / United States
R01 MH102392 / MH / NIMH NIH HHS / United States
R01 EB017255 / EB / NIBIB NIH HHS / United States
R01 AG037376 / AG / NIA NIH HHS / United States
R00 AG036848 / AG / NIA NIH HHS / United States
R00 AG036818 / AG / NIA NIH HHS / United States
R37 AG011230 / AG / NIA NIH HHS / United States
R21 AG049220 / AG / NIA NIH HHS / United States
R01 NS076856 / NS / NINDS NIH HHS / United States
R01 MH107512 / MH / NIMH NIH HHS / United States

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