GABA predicts time perception.

TitleGABA predicts time perception.
Publication TypeJournal Article
Year of Publication2014
AuthorsTerhune DB, Russo S, Near J, Stagg CJ, Kadosh RCohen
JournalJ Neurosci
Volume34
Issue12
Pagination4364-70
Date Published2014 Mar 19
ISSN1529-2401
KeywordsAdolescent, Adult, Female, gamma-Aminobutyric Acid, Humans, Magnetic Resonance Spectroscopy, Male, Photic Stimulation, Time Perception, Visual Cortex, Visual Perception
Abstract

Our perception of time constrains our experience of the world and exerts a pivotal influence over a myriad array of cognitive and motor functions. There is emerging evidence that the perceived duration of subsecond intervals is driven by sensory-specific neural activity in human and nonhuman animals, but the mechanisms underlying individual differences in time perception remain elusive. We tested the hypothesis that elevated visual cortex GABA impairs the coding of particular visual stimuli, resulting in a dampening of visual processing and concomitant positive time-order error (relative underestimation) in the perceived duration of subsecond visual intervals. Participants completed psychophysical tasks measuring visual interval discrimination and temporal reproduction and we measured in vivo resting state GABA in visual cortex using magnetic resonance spectroscopy. Time-order error selectively correlated with GABA concentrations in visual cortex, with elevated GABA associated with a rightward horizontal shift in psychometric functions, reflecting a positive time-order error (relative underestimation). These results demonstrate anatomical, neurochemical, and task specificity and suggest that visual cortex GABA contributes to individual differences in time perception.

DOI10.1523/JNEUROSCI.3972-13.2014
Alternate JournalJ. Neurosci.
PubMed ID24647956
PubMed Central IDPMC3960474
Grant ListWT88378 / / Wellcome Trust / United Kingdom