Functional neural correlates of social approval in schizophrenia.

TitleFunctional neural correlates of social approval in schizophrenia.
Publication TypeJournal Article
Year of Publication2016
AuthorsMakowski CS, Lepage M, Harvey P-O
JournalSoc Cogn Affect Neurosci
Volume11
Issue3
Pagination445-57
Date Published2016 Mar
ISSN1749-5024
KeywordsAdult, Brain Mapping, Cognition, Feedback, Psychological, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parietal Lobe, Personality, Reward, Schizophrenia, Schizophrenic Psychology, Social Behavior, Young Adult
Abstract

Social approval is a reward that uses abstract social reinforcers to guide interpersonal interactions. Few studies have specifically explored social reward processing and its related neural substrates in schizophrenia. Fifteen patients with schizophrenia and fifteen healthy controls participated in a two-part study to explore the functional neural correlates of social approval. In the first session, participants were led to believe their personality would be assessed based on their results from various questionnaires and an interview. Participants were then presented with the results of their supposed evaluation in the scanner, while engaging in a relevant fMRI social approval task. Subjects provided subjective reports of pleasure associated with receiving self-directed positive or negative feedback. Higher activation of the right parietal lobe was found in controls compared with individuals with schizophrenia. Both groups rated traits from the high social reward condition as more pleasurable than the low social reward condition, while intergroup differences emerged in the low social reward condition. Positive correlations were found in patients only between subjective ratings of positive feedback and right insula activation, and a relevant behavioural measure. Evidence suggests potential neural substrates underlying the cognitive representation of social reputation in schizophrenia.

DOI10.1093/scan/nsv125
Alternate JournalSoc Cogn Affect Neurosci
PubMed ID26516171
PubMed Central IDPMC4769627

McGill Logo

CIUSSS ouest montreal logo

 



  • Douglas Hospital
  • Dobell Pavillion
  • Brain imaging centre