Volumetric navigated MEGA-SPECIAL for real-time motion and shim corrected GABA editing.

TitleVolumetric navigated MEGA-SPECIAL for real-time motion and shim corrected GABA editing.
Publication TypeJournal Article
Year of Publication2016
AuthorsSaleh MG, Alhamud A, Near J, van der Kouwe AJW, Meintjes EM
JournalNMR Biomed
Date Published2016 Mar
Keywordsgamma-Aminobutyric Acid, Humans, Magnetic Resonance Spectroscopy, Phantoms, Imaging, Spin Labels

Mescher-Garwood (MEGA) editing with spin echo full intensity acquired localization (MEGA-SPECIAL, MSpc) is a technique to acquire γ-aminobutyric acid (GABA) without macromolecule (MM) contamination at a TE of 68 ms. However, due to the requirement of multiple shot-localization, it is often susceptible to subject motion and B0 inhomogeneity. A method is presented for real-time shim and motion correction (ShMoCo) using volumetric navigators to correct for motion and motion-related B0 inhomogeneity during MSpc acquisition. A phantom experiment demonstrates that ShMoCo restores the GABA peak and improves spectral quality in the presence of motion and zero- and first-order shim changes. The ShMoCo scans were validated in three subjects who performed up-down and left-right head rotations. Qualitative assessment of these scans indicates effective reduction of subtraction artefacts and well edited GABA peaks, while quantitative analysis indicates superior fitting and spectral quality relative to scans with no correction. Copyright © 2015 John Wiley & Sons, Ltd.

Alternate JournalNMR Biomed
PubMed ID26663075
Grant ListR01HD071664 / HD / NICHD NIH HHS / United States