Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.
Title | Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille J-C, Gobbi G, Sonenberg N |
Journal | Nat Commun |
Volume | 9 |
Issue | 1 |
Pagination | 2459 |
Date Published | 2018 Jun 25 |
ISSN | 2041-1723 |
Abstract | Translation of mRNA into protein has a fundamental role in neurodevelopment, plasticity, and memory formation; however, its contribution in the pathophysiology of depressive disorders is not fully understood. We investigated the involvement of MNK1/2 (MAPK-interacting serine/threonine-protein kinase 1 and 2) and their target, eIF4E (eukaryotic initiation factor 4E), in depression-like behavior in mice. Mice carrying a mutation in eIF4E for the MNK1/2 phosphorylation site (Ser209Ala, Eif4e ki/ki), the Mnk1/2 double knockout mice (Mnk1/2), or mice treated with the MNK1/2 inhibitor, cercosporamide, displayed anxiety- and depression-like behaviors, impaired serotonin-induced excitatory synaptic activity in the prefrontal cortex, and diminished firing of the dorsal raphe neurons. In Eif4e ki/ki mice, brain IκBα, was decreased, while the NF-κB target, TNFα was elevated. TNFα inhibition in Eif4e ki/ki mice rescued, whereas TNFα administration to wild-type mice mimicked the depression-like behaviors and 5-HT synaptic deficits. We conclude that eIF4E phosphorylation modulates depression-like behavior through regulation of inflammatory responses. |
DOI | 10.1038/s41467-018-04883-5 |
Alternate Journal | Nat Commun |
PubMed ID | 29941989 |
PubMed Central ID | PMC6018502 |
Grant List | FND-148423 / / Canadian Health Services Research Foundation (Fondation Canadianne de la Recherche sur les Service de Santé) / |