Transcriptomic and epigenomic biomarkers of antidepressant response.
|Title||Transcriptomic and epigenomic biomarkers of antidepressant response.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Belzeaux R, Lin R, Ju C, Chay M-A, Fiori LM, Lutz P-E, Turecki G|
|Journal||J Affect Disord|
|Date Published||2017 Sep 08|
BACKGROUND: Antidepressant treatment is associated with a high rate of poor response, and thus, biomarker development is warranted.METHODS: We aimed to synthesize studies investigating gene expression, small RNAs, and epigenomic biomarkers of antidepressant response. We conducted a narrative review of the literature.RESULTS: Firstly, we detailed the challenges involved, in terms of biological tissues, relevant study time frames, and mandatory statistical tools. Secondly we synthesized results obtained in gene expression studies, focusing mainly on genome-wide studies, particularly small non-coding RNA, including micro-RNA and other small RNA species. In addition, we reviewed the potential biomarkers of antidepressant response arising from studies investigating DNA methylation variation and histone modifications.LIMITATIONS: We did not conduct a meta-analysis due to the heterogeneity of the study.CONCLUSION: Although promising, the field of gene expression and epigenomic biomarkers of antidepressant response is still in its infancy, and needs further development to define useful biomarkers in clinical practice.
|Alternate Journal||J Affect Disord|