Transcriptomic and epigenomic biomarkers of antidepressant response.
Title | Transcriptomic and epigenomic biomarkers of antidepressant response. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Belzeaux R, Lin R, Ju C, Chay M-A, Fiori LM, Lutz P-E, Turecki G |
Journal | J Affect Disord |
Date Published | 2017 Sep 08 |
ISSN | 1573-2517 |
Abstract | BACKGROUND: Antidepressant treatment is associated with a high rate of poor response, and thus, biomarker development is warranted.METHODS: We aimed to synthesize studies investigating gene expression, small RNAs, and epigenomic biomarkers of antidepressant response. We conducted a narrative review of the literature.RESULTS: Firstly, we detailed the challenges involved, in terms of biological tissues, relevant study time frames, and mandatory statistical tools. Secondly we synthesized results obtained in gene expression studies, focusing mainly on genome-wide studies, particularly small non-coding RNA, including micro-RNA and other small RNA species. In addition, we reviewed the potential biomarkers of antidepressant response arising from studies investigating DNA methylation variation and histone modifications.LIMITATIONS: We did not conduct a meta-analysis due to the heterogeneity of the study.CONCLUSION: Although promising, the field of gene expression and epigenomic biomarkers of antidepressant response is still in its infancy, and needs further development to define useful biomarkers in clinical practice. |
DOI | 10.1016/j.jad.2017.08.087 |
Alternate Journal | J Affect Disord |
PubMed ID | 28918100 |