Synergistic interaction between amyloid and tau predicts the progression to dementia.
|Title||Synergistic interaction between amyloid and tau predicts the progression to dementia.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Pascoal TA, Mathotaarachchi S, Shin M, Benedet AL, Mohades S, Wang S, Beaudry T, Kang MSu, Soucy J-P, Labbe A, Gauthier S, Rosa-Neto P|
|Corporate Authors||Alzheimer's Disease Neuroimaging Initiative|
|Date Published||2017 Jun|
INTRODUCTION: Recent literature proposes that amyloid β (Aβ) and phosphorylated tau (p-tau) synergism accelerates biomarker abnormalities in controls. Yet, it remains to be answered whether this synergism is the driving force behind Alzheimer disease (AD) dementia.METHODS: We stratified 314 mild cognitive impairment individuals using [(18)F]florbetapir positron emission tomography Aβ imaging and cerebrospinal fluid p-tau. Regression and voxel-based logistic regression models with interaction terms evaluated 2-year changes in cognition and clinical status as a function of baseline biomarkers.RESULTS: We found that the synergism between [(18)F]florbetapir and p-tau, rather than their additive effects, was associated with the cognitive decline and progression to AD. Furthermore, voxel-based analysis revealed that temporal and inferior parietal were the regions where the synergism determined an increased likelihood of developing AD.DISCUSSION: Together, the present results support that progression to AD dementia is driven by the synergistic rather than a mere additive effect between Aβ and p-tau proteins.
|Alternate Journal||Alzheimers Dement|