Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways.

TitleSymptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways.
Publication TypeJournal Article
Year of Publication2015
AuthorsShenk CE, Griffin AM, O'Donnell K
JournalDev Psychopathol
Volume27
Issue4 Pt 2
Pagination1503-14
Date Published2015 Nov
ISSN1469-2198
KeywordsAdolescent, Adult, alpha-Amylases, Child Abuse, Depressive Disorder, Major, Emotions, Female, Humans, Hydrocortisone, Risk, Self-Control, Young Adult
Abstract

Major depressive disorder (MDD) is a prevalent psychiatric condition in the child maltreatment population. However, not all children who have been maltreated will develop MDD or MDD symptoms, suggesting the presence of unique risk pathways that explain how certain children develop MDD symptoms when others do not. The current study tested several candidate risk pathways to MDD symptoms following child maltreatment: neuroendocrine, autonomic, affective, and emotion regulation. Female adolescents (N = 110; age range = 14-19) were recruited into a substantiated child maltreatment or comparison condition and completed a laboratory stressor, saliva samples, and measures of emotion regulation, negative affect, and MDD symptoms. MDD symptoms were reassessed 18 months later. Mediational modeling revealed that emotion regulation was the only significant indirect effect of the relationship between child maltreatment and subsequent MDD symptoms, demonstrating that children exposed to maltreatment had greater difficulties managing affective states that in turn led to more severe MDD symptoms. These results highlight the importance of emotion dysregulation as a central risk pathway to MDD following child maltreatment. Areas of future research and implications for optimizing prevention and clinical intervention through the direct targeting of transdiagnostic risk pathways are discussed.

DOI10.1017/S0954579415000905
Alternate JournalDev. Psychopathol.
PubMed ID26535940
PubMed Central IDPMC4774890
Grant ListKL2 TR000078 / TR / NCATS NIH HHS / United States
T32DA017629 / DA / NIDA NIH HHS / United States
T32 DA017629 / DA / NIDA NIH HHS / United States
KL2TR000078-05 / TR / NCATS NIH HHS / United States
UL1 TR001425 / TR / NCATS NIH HHS / United States