Superficial white matter as a novel substrate of age-related cognitive decline.

TitleSuperficial white matter as a novel substrate of age-related cognitive decline.
Publication TypeJournal Article
Year of Publication2015
AuthorsNazeri A, M Chakravarty M, Rajji TK, Felsky D, Rotenberg DJ, Mason M, Xu LN, Lobaugh NJ, Mulsant BH, Voineskos AN
JournalNeurobiol Aging
Volume36
Issue6
Pagination2094-106
Date Published2015 Jun
ISSN1558-1497
Abstract

Studies of diffusion tensor imaging have focused mainly on the role of deep white matter tract microstructural abnormalities associated with aging and age-related cognitive decline. However, the potential role of superficial white matter (SWM) in aging and, by extension, cognitive-aging, is less clear. Healthy individuals (n = 141; F/M: 66/75 years) across the adult lifespan (18-86 years) underwent diffusion tensor imaging and a battery of cognitive testing. SWM was assessed via a combination of probabilistic tractography and tract-based spatial statistics (TBSS). A widespread inverse relationship of fractional anisotropy (FA) values in SWM with age was observed. SWM-FA adjacent to the precentral gyri was associated with fine-motor-speed, whereas performance in visuomotor-attention/processing speed correlated with SWM-FA in all 4 lobes of the left-hemisphere and in right parieto-occipital SWM-FA (family-wise error corrected p < 0.05). Independent of deep white matter-FA, right frontal and right occipital SWM-FA-mediated age effects on motor-speed and visuomotor-attention/processing speed, respectively. Altogether, our results indicate that SWM-FA contributes uniquely to age-related cognitive performance, and should be considered as a novel biomarker of cognitive-aging.

DOI10.1016/j.neurobiolaging.2015.02.022
Alternate JournalNeurobiol. Aging
PubMed ID25834938
Grant ListR01MH099167 / MH / NIMH NIH HHS / United States
R01MH102324 / MH / NIMH NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada

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