The Role of Epigenetic Dysregulation in Suicidal Behaviors.

TitleThe Role of Epigenetic Dysregulation in Suicidal Behaviors.
Publication TypeJournal Article
Year of Publication2020
AuthorsFiori LM, Turecki G
JournalCurr Top Behav Neurosci
Date Published2020 Jul 24
ISSN1866-3370
Abstract

Suicidal behaviors have been associated with both heritable genetic variables and environmental risk factors. Epigenetic processes, such as DNA methylation, have important roles in mediating the effects of the environment on behavior. Dysregulation of these processes has been observed in many psychiatric disorders, and evidence suggests that they may also be involved in suicidal behaviors. Herein, we have summarized candidate gene and epigenome-wide studies which have investigated DNA methylation in relation to suicidal behaviors, as well as discussed some of the limitations of the field to date.

DOI10.1007/7854_2020_160
Alternate JournalCurr Top Behav Neurosci
PubMed ID32705498