Resting state executive control network adaptations in amnestic mild cognitive impairment.

TitleResting state executive control network adaptations in amnestic mild cognitive impairment.
Publication TypeJournal Article
Year of Publication2014
AuthorsWu L, Soder RBernardi, Schoemaker D, Carbonnell F, Sziklas V, Rowley J, Mohades S, Fonov V, Bellec P, Dagher A, Shmuel A, Jia J, Gauthier S, Rosa-Neto P
JournalJ Alzheimers Dis
Volume40
Issue4
Pagination993-1004
Date Published2014
ISSN1875-8908
KeywordsAged, Amnesia, Brain Mapping, Cerebral Cortex, Executive Function, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Mild Cognitive Impairment, Nerve Net, Neuropsychological Tests, Oxygen, Rest
Abstract

Executive dysfunction is frequently associated with episodic memory decline in amnestic mild cognitive impairment (aMCI) patients. Resting state executive control network (RS-ECN) represents a novel approach to interrogate the integrity of brain areas underlying executive dysfunction. The present study aims to investigate RS-ECN in aMCI and examine a possible link between changes in brain functional connectivity and declines in executive function. aMCI individuals (n = 13) and healthy subjects (n = 16) underwent cognitive assessment including executive function and high field functional magnetic resonance imaging. Individual RS-ECN maps were estimated using a seed-based cross-correlation method. Between groups RS-ECN functional connectivity comparison was assessed using voxel-wise statistic parametric mapping. aMCI individuals had reduced RS-ECN connectivity in the anterior cingulate cortex (ACC) and dorsal lateral prefrontal cortex (DLPFC), bilaterally. In contrast, aMCI showed increased connectivity in ventral lateral and anterior prefrontal cortex, bilaterally. Connectivity strength was associated with executive function in the ACC (r = 0.6213, p = 0.023) and right DLPFC (r = 0.6454, p = 0.017). Coexistence between connectivity declines and recruitment of brain regions outside the RS-ECN as reported here fits a brain reserve conceptual framework in which brain networks undergo remodeling in aMCI individuals.

DOI10.3233/JAD-131574
Alternate JournalJ. Alzheimers Dis.
PubMed ID24583406

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