Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons.
| Title | Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Isingrini E, Perret L, Rainer Q, Amilhon B, Guma E, Tanti A, Martin G, Robinson J, Moquin L, Marti F, Mechawar N, Williams S, Gratton A, Giros B |
| Journal | Nat Neurosci |
| Volume | 19 |
| Issue | 4 |
| Pagination | 560-3 |
| Date Published | 2016 Apr |
| ISSN | 1546-1726 |
| Keywords | Adrenergic Neurons, Animals, Chronic Disease, Dopaminergic Neurons, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Neural Inhibition, Norepinephrine, Resilience, Psychological, Stress, Psychological, Ventral Tegmental Area, Vesicular Monoamine Transport Proteins |
| Abstract | Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress susceptibility and resilience. However, upstream mechanisms controlling these neurons remain unknown. Noradrenergic (NE) neurons in the locus coeruleus, implicated in the pathophysiology of depression, have direct connections within the VTA. Here we demonstrate that NE neurons regulate vulnerability to social defeat through inhibitory control of VTA DA neurons. |
| DOI | 10.1038/nn.4245 |
| Alternate Journal | Nat. Neurosci. |
| PubMed ID | 26878672 |