Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder.
|Title||Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Gouveia FVenetucci, Germann J, Devenyi GA, Morais RMCB, Santos APaula M, Fonoff ET, Hamani C, Brentani H, Chakravarty MM, Martinez RCR|
|Date Published||2020 Aug 07|
Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions.
|Alternate Journal||BJPsych Open|
|PubMed Central ID||PMC7453794|