The ratio of posterior–anterior medial temporal lobe volumes predicts source memory performance in healthy young adults

TitleThe ratio of posterior–anterior medial temporal lobe volumes predicts source memory performance in healthy young adults
Publication TypeJournal Article
Year of Publication2020
AuthorsSnytte J, Elshiekh A, Subramaniapillai S, Manning L, Pasvanis S, Devenyi GA, Olsen RK, Maria Rajah N
JournalHippocampusHippocampusHippocampus
Volume30
Issue11
Pagination1209 - 1227
Date Published2020/11/01
ISBN Number1050-9631
Keywordsanterior, episodic memory, Hippocampus, medial temporal lobe, perirhinal, posterior, source
Abstract

Abstract A functional gradient has been proposed across the medial temporal lobes (MTL) such that the anterior MTL is thought to support processing of individual items (e.g., item memory and complex object perception), whereas the posterior MTL is thought to support item-context retrieval (e.g., source memory). Whereas functional imaging studies have provided evidence supporting this anatomical organization, results from structural analyses remain inconclusive. The current study examined the relationship between volume of MTL regions of interest (ROIs), and performance on a source memory task and a fine-grain complex object perception task, in healthy young adults (mean age = 21.5, range = 18?29). Using a semiautomated procedure, we segmented the parahippocampal and perirhinal cortices (PHC, PRC), posteromedial and anterolateral entorhinal cortices (pmERC, alERC), and posterior and anterior hippocampus (postHC, antHC) on high-resolution T2-weighted MRIs. Regional volumes were computed as proportions of intracranial volume, and as posterior?anterior volumetric ratios (PHC:PRC, pmERC:alERC, postHC:antHC). Partial-least squares regressions were applied to predict source and item memory, and perceptual discrimination accuracy, based on ROI and ratio volumes. In our ROI regressions, we found that postHC volume was positively correlated with a latent factor predicting source memory, and PRC and antHC volumes were negatively correlated to this latent factor. In our ratio regressions, we observed an effect relating the posterior?anterior distribution of gray matter across the MTL with source memory. Our results demonstrate differential associations between anterior and posterior MTL and source memory performance. Findings from this study highlight the importance of considering patterns of structure?behavior associations in the neurobiology of episodic memory.

URLhttps://doi.org/10.1002/hipo.23251
Short TitleHippocampus