Rapid hippocampal plasticity supports motor sequence learning.

TitleRapid hippocampal plasticity supports motor sequence learning.
Publication TypeJournal Article
Year of Publication2020
AuthorsJacobacci F, Armony JL, Yeffal A, Lerner G, Amaro E, Jovicich J, Doyon J, Della-Maggiore V
JournalProc Natl Acad Sci U S A
Volume117
Issue38
Pagination23898-23903
Date Published2020 09 22
ISSN1091-6490
Abstract

Recent evidence suggests that gains in performance observed while humans learn a novel motor sequence occur during the quiet rest periods interleaved with practice (micro-offline gains, MOGs). This phenomenon is reminiscent of memory replay observed in the hippocampus during spatial learning in rodents. Whether the hippocampus is also involved in the production of MOGs remains currently unknown. Using a multimodal approach in humans, here we show that activity in the hippocampus and the precuneus increases during the quiet rest periods and predicts the level of MOGs before asymptotic performance is achieved. These functional changes were followed by rapid alterations in brain microstructure in the order of minutes, suggesting that the same network that reactivates during the quiet periods of training undergoes structural plasticity. Our work points to the involvement of the hippocampal system in the reactivation of procedural memories.

DOI10.1073/pnas.2009576117
Alternate JournalProc Natl Acad Sci U S A
PubMed ID32900965
PubMed Central IDPMC7519327