Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol.

TitleQuantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol.
Publication TypeJournal Article
Year of Publication2015
AuthorsYushkevich PA, Amaral RSC, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren AC, Carr VA, M Chakravarty M, Chételat G, Daugherty AM, Davachi L, Ding S-L, Ekstrom A, Geerlings MI, Hassan A, Huang Y, J Iglesias E, La Joie R, Kerchner GA, LaRocque KF, Libby LA, Malykhin N, Mueller SG, Olsen RK, Palombo DJ, Parekh MB, Pluta JB, Preston AR, Pruessner JC, Ranganath C, Raz N, Schlichting ML, Schoemaker D, Singh S, Stark CEL, Suthana N, Tompary A, Turowski MM, Van Leemput K, Wagner AD, Wang L, Winterburn JL, Wisse LEM, Yassa MA, Zeineh MM
Corporate AuthorsHippocampal Subfields Group(HSG)
JournalNeuroimage
Volume111
Pagination526-41
Date Published2015 May 1
ISSN1095-9572
Abstract

OBJECTIVE: An increasing number of human in vivo magnetic resonance imaging (MRI) studies have focused on examining the structure and function of the subfields of the hippocampal formation (the dentate gyrus, CA fields 1-3, and the subiculum) and subregions of the parahippocampal gyrus (entorhinal, perirhinal, and parahippocampal cortices). The ability to interpret the results of such studies and to relate them to each other would be improved if a common standard existed for labeling hippocampal subfields and parahippocampal subregions. Currently, research groups label different subsets of structures and use different rules, landmarks, and cues to define their anatomical extents. This paper characterizes, both qualitatively and quantitatively, the variability in the existing manual segmentation protocols for labeling hippocampal and parahippocampal substructures in MRI, with the goal of guiding subsequent work on developing a harmonized substructure segmentation protocol.METHOD: MRI scans of a single healthy adult human subject were acquired both at 3 T and 7 T. Representatives from 21 research groups applied their respective manual segmentation protocols to the MRI modalities of their choice. The resulting set of 21 segmentations was analyzed in a common anatomical space to quantify similarity and identify areas of agreement.RESULTS: The differences between the 21 protocols include the region within which segmentation is performed, the set of anatomical labels used, and the extents of specific anatomical labels. The greatest overall disagreement among the protocols is at the CA1/subiculum boundary, and disagreement across all structures is greatest in the anterior portion of the hippocampal formation relative to the body and tail.CONCLUSIONS: The combined examination of the 21 protocols in the same dataset suggests possible strategies towards developing a harmonized subfield segmentation protocol and facilitates comparison between published studies.

DOI10.1016/j.neuroimage.2015.01.004
Alternate JournalNeuroimage
PubMed ID25596463
PubMed Central IDPMC4387011
Grant ListF32 AG005778 / AG / NIA NIH HHS / United States
F32-MH087012 / MH / NIMH NIH HHS / United States
K01 DA034728 / DA / NIDA NIH HHS / United States
K01-DA034728 / DA / NIDA NIH HHS / United States
K23 AG042858 / AG / NIA NIH HHS / United States
K23-AG042858 / AG / NIA NIH HHS / United States
MOP 111049 / / Canadian Institutes of Health Research / Canada
MOP 115011 / / Canadian Institutes of Health Research / Canada
MOP-62963 / / Canadian Institutes of Health Research / Canada
P41-EB015896 / EB / NIBIB NIH HHS / United States
P50 AG016573 / AG / NIA NIH HHS / United States
P50-AG016573 / AG / NIA NIH HHS / United States
R01 AG013308 / AG / NIA NIH HHS / United States
R01 AG034613 / AG / NIA NIH HHS / United States
R01 AG037376 / AG / NIA NIH HHS / United States
R01 AG037376 / AG / NIA NIH HHS / United States
R01 AG048076 / AG / NIA NIH HHS / United States
R01 EB013565 / EB / NIBIB NIH HHS / United States
R01 MH074692 / MH / NIMH NIH HHS / United States
R01 MH076932 / MH / NIMH NIH HHS / United States
R01 MH083734 / MH / NIMH NIH HHS / United States
R01 MH100121 / MH / NIMH NIH HHS / United States
R01 NS076856 / NS / NINDS NIH HHS / United States
R01-AG013308 / AG / NIA NIH HHS / United States
R01-AG034613 / AG / NIA NIH HHS / United States
R01-AG037376 / AG / NIA NIH HHS / United States
R01-AG048076 / AG / NIA NIH HHS / United States
R01-EB013565 / EB / NIBIB NIH HHS / United States
R01-MH074692 / MH / NIMH NIH HHS / United States
R01-MH076932 / MH / NIMH NIH HHS / United States
R01-MH083734 / MH / NIMH NIH HHS / United States
R01-MH100121 / MH / NIMH NIH HHS / United States
R01-NS076856 / NS / NINDS NIH HHS / United States
R37 AG011230 / AG / NIA NIH HHS / United States
R37-AG011230 / AG / NIA NIH HHS / United States
T35 AG029793 / AG / NIA NIH HHS / United States
T90 431587-BH-29793 / BH / FDA HHS / United States

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