Quantitative assessment of white matter injury in preterm neonates: Association with outcomes.

TitleQuantitative assessment of white matter injury in preterm neonates: Association with outcomes.
Publication TypeJournal Article
Year of Publication2017
AuthorsGuo T, Duerden EG, Adams E, Chau V, Branson HM, M Chakravarty M, Poskitt KJ, Synnes A, Grunau RE, Miller SP
JournalNeurology
Volume88
Issue7
Pagination614-622
Date Published2017 Feb 14
ISSN1526-632X
KeywordsBrain, Cerebral Palsy, Child Development, Cognition Disorders, Developmental Disabilities, Female, Follow-Up Studies, Humans, Image Interpretation, Computer-Assisted, Infant, Infant, Extremely Premature, Infant, Newborn, Language Development Disorders, Magnetic Resonance Imaging, Male, Movement Disorders, Multivariate Analysis, Odds Ratio, Prognosis, White Matter
Abstract

OBJECTIVE: To quantitatively assess white matter injury (WMI) volume and location in very preterm neonates, and to examine the association of lesion volume and location with 18-month neurodevelopmental outcomes.METHODS: Volume and location of WMI was quantified on MRI in 216 neonates (median gestational age 27.9 weeks) who had motor, cognitive, and language assessments at 18 months corrected age (CA). Neonates were scanned at 32.1 postmenstrual weeks (median) and 68 (31.5%) had WMI; of 66 survivors, 58 (87.9%) had MRI and 18-month outcomes. WMI was manually segmented and transformed into a common image space, accounting for intersubject anatomical variability. Probability maps describing the likelihood of a lesion predicting adverse 18-month outcomes were developed.RESULTS: WMI occurs in a characteristic topology, with most lesions occurring in the periventricular central region, followed by posterior and frontal regions. Irrespective of lesion location, greater WMI volumes predicted poor motor outcomes (p = 0.001). Lobar regional analysis revealed that greater WMI volumes in frontal, parietal, and temporal lobes have adverse motor outcomes (all, p < 0.05), but only frontal WMI volumes predicted adverse cognitive outcomes (p = 0.002). To account for lesion location and volume, voxel-wise odds ratio (OR) maps demonstrate that frontal lobe lesions predict adverse cognitive and language development, with maximum odds ratios (ORs) of 78.9 and 17.5, respectively, while adverse motor outcomes are predicted by widespread injury, with maximum OR of 63.8.CONCLUSIONS: The predictive value of frontal lobe WMI volume highlights the importance of lesion location when considering the neurodevelopmental significance of WMI. Frontal lobe lesions are of particular concern.

DOI10.1212/WNL.0000000000003606
Alternate JournalNeurology
PubMed ID28100727
PubMed Central IDPMC5317385

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