Processing of decision-making and social threat in patients with history of suicidal attempt: A neuroimaging replication study.

TitleProcessing of decision-making and social threat in patients with history of suicidal attempt: A neuroimaging replication study.
Publication TypeJournal Article
Year of Publication2015
AuthorsOlié E, Ding Y, Le Bars E, de Champfleur NMenjot, Mura T, Bonafé A, Courtet P, Jollant F
JournalPsychiatry Res
Volume234
Issue3
Pagination369-77
Date Published2015 Dec 30
ISSN1872-7123
KeywordsAdolescent, Adult, Anger, Case-Control Studies, Choice Behavior, Decision Making, Emotions, Female, Gambling, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Prefrontal Cortex, Reward, Suicidal Ideation, Suicide, Attempted, Young Adult
Abstract

Suicidal vulnerability has been related to impaired value-based decision-making and increased sensitivity to social threat, mediated by the prefrontal cortex. Using functional magnetic resonance imaging, we aimed at replicating these previous findings by measuring brain activation during the Iowa Gambling Task and an emotional faces viewing task. Participants comprised 15 euthymic suicide attempters (history of depression and suicidal behavior) who were compared with 23 euthymic patient controls (history of depression without suicidal history) and 35 healthy controls. The following five model-based regions of interest were investigated: the orbitofrontal cortex (OFC), ventrolateral prefrontal cortex (VLPFC), anterior cingulate cortex (ACC), medial (MPFC) and dorsal prefrontal cortex (DPFC). Suicide attempters relative to patient controls showed (1) increased response to angry vs. neutral faces in the left OFC and the VLPFC, as previously reported; (2) increased response to wins vs. losses in the right OFC, DPFC and ACC; (3) decreased response to risky vs. safe choices in the left DPFC; and (4) decreased response to sad vs. neutral faces in the right ACC. This study links impaired valuation processing (here for signals of social threat, sadness and reward) to prefrontal cortex dysfunction in suicide attempters. These long-term deficits may underlie the impaired decision-making and social difficulties found in suicide attempters.

DOI10.1016/j.pscychresns.2015.09.020
Alternate JournalPsychiatry Res
PubMed ID26483212