Prenatal maternal mood is associated with altered diurnal cortisol in adolescence.
|Title||Prenatal maternal mood is associated with altered diurnal cortisol in adolescence.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||O'Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O'Connor TG|
|Date Published||2013 Sep|
|Keywords||Adolescent, Affect, Anxiety, Circadian Rhythm, Depression, Female, Follow-Up Studies, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Saliva, Sampling Studies, Secretory Rate, Severity of Illness Index, Socioeconomic Factors, Wakefulness|
BACKGROUND: Experimental animal work shows that prenatal stress has a persisting effect on the hypothalamic-pituitary-adrenal (HPA) axis of offspring. The implications of these findings for human health and development are not yet clear.METHODS: The data are based on the ALSPAC cohort, a prospective longitudinal study of a community sample that has followed mothers and children from pregnancy. When the children were aged 15 years, diurnal cortisol samples were collected at wake-up, 30 min post-awakening and at afternoon and evening times on up to three consecutive days on n=889 adolescents. Diurnal cortisol was predicted from prenatal anxiety and depression, obstetric, life-style, socio-demographic, and postnatal covariates.RESULTS: Multilevel model analysis indicated that maternal prenatal anxiety was associated with a modest alteration of diurnal cortisol, indexed by a reduced cortisol awakening response and flatter diurnal slope. The effects were independent of psychosocial and obstetric covariates and measures of maternal postnatal anxiety; effects were similar for prenatal maternal depression. There was no association between adolescent cortisol and paternal prenatal anxiety.CONCLUSIONS: There are small but persisting associations between maternal prenatal mood and diurnal cortisol in the child that persist into adolescence and may constitute a programming effect.
|PubMed Central ID||PMC3695029|
|Grant List||R01 MH073842 / MH / NIMH NIH HHS / United States |
092731 / / Wellcome Trust / United Kingdom
74882 / / Medical Research Council / United Kingdom
076467 / / Wellcome Trust / United Kingdom
G9815508 / / Medical Research Council / United Kingdom