Preliminary Evaluations of [C]Verubulin: Implications for Microtubule Imaging With PET.
| Title | Preliminary Evaluations of [C]Verubulin: Implications for Microtubule Imaging With PET. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Lindberg A, Mossine AV, Aliaga A, Hopewell R, Massarweh G, Rosa-Neto P, Shao X, Bernard-Gauthier V, Scott PJH, Vasdev N |
| Journal | Front Neurosci |
| Volume | 15 |
| Pagination | 725873 |
| Date Published | 2021 |
| ISSN | 1662-4548 |
| Abstract | [C]Verubulin (a.k.a.[C]MCP-6827), [C]HD-800 and [C]colchicine have been developed for imaging microtubules (MTs) with positron emission tomography (PET). The objective of this work was to conduct an comparison of [C]verubulin for MT imaging in mouse and rat brain, as well as an study with this radiotracer in rodent and human Alzheimer's Disease tissue. Our preliminary PET imaging studies of [C]verubulin in rodents revealed contradictory results between mouse and rat brain uptake under pretreatment conditions. autoradiography with [C]verubulin showed an unexpected higher uptake in AD patient tissue compared with healthy controls. We also conducted the first comparative PET imaging study with [C]verubulin, [C]HD-800 and [C]colchicine in a non-human primate. [C]Verubulin and [C]HD-800 require pharmacokinetic modeling and quantification studies to understand the role of how these radiotracers bind to MTs before translation to human use. |
| DOI | 10.3389/fnins.2021.725873 |
| Alternate Journal | Front Neurosci |
| PubMed ID | 34566568 |
| PubMed Central ID | PMC8456034 |