Preconception origins of perinatal maternal mental health.

TitlePreconception origins of perinatal maternal mental health.
Publication TypeJournal Article
Year of Publication2021
AuthorsKee MZL, Ponmudi S, Phua DY, Rifkin-Graboi A, Chong YSeng, Tan KHian, Chan JKok Yen, Broekman BFP, Chen H, Meaney MJ
JournalArch Womens Ment Health
Date Published2021 08
KeywordsAnxiety, Depression, Depression, Postpartum, Female, Humans, Mental Health, Parturition, Pregnancy, Prospective Studies

Perinatal maternal symptoms of depression and anxiety compromise psychosocial function and influence developmental outcomes in the offspring. The onset of symptoms remains unclear with findings that suggest a preconceptual origin. We addressed this issue with a prospective analysis of anxiety and depressive symptom profiles from preconception through to parturition. Women were recruited into a preconception study to assess (a) variation in symptom levels of depression and anxiety from pre- to post-conception and (b) if the symptom network profiles of depression and anxiety change from pre-conception to post-conception. A within-subject intraclass correlation analyses revealed that symptoms of depression or anxiety in the preconception phase strongly predicted those across pregnancy and into the early postnatal period. The symptom network analysis revealed that the symptom profiles remained largely unchanged from preconception into the second trimester. Our findings suggest that for a significant portion of women, maternal mental health remains stable from preconception into pregnancy. This finding highlights the need for early intervention studies on women's mental health to be targeted during the preconception period and to be extended across the population.

Alternate JournalArch Womens Ment Health
PubMed ID33486655
PubMed Central IDPMC8266713
Grant ListNMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014 / / National Medical Research Council (NMRC) Singapore /