Normative brain size variation and brain shape diversity in humans.

TitleNormative brain size variation and brain shape diversity in humans.
Publication TypeJournal Article
Year of Publication2018
AuthorsReardon PK, Seidlitz J, Vandekar S, Liu S, Patel R, Park MTae M, Alexander-Bloch A, Clasen LS, Blumenthal JD, Lalonde FM, Giedd JN, Gur RC, Gur RE, Lerch JP, M Chakravarty M, Satterthwaite TD, Shinohara RT, Raznahan A
JournalScience
Volume360
Issue6394
Pagination1222-1227
Date Published2018 06 15
ISSN1095-9203
Abstract

Brain size variation over primate evolution and human development is associated with shifts in the proportions of different brain regions. Individual brain size can vary almost twofold among typically developing humans, but the consequences of this for brain organization remain poorly understood. Using in vivo neuroimaging data from more than 3000 individuals, we find that larger human brains show greater areal expansion in distributed frontoparietal cortical networks and related subcortical regions than in limbic, sensory, and motor systems. This areal redistribution recapitulates cortical remodeling across evolution, manifests by early childhood in humans, and is linked to multiple markers of heightened metabolic cost and neuronal connectivity. Thus, human brain shape is systematically coupled to naturally occurring variations in brain size through a scaling map that integrates spatiotemporally diverse aspects of neurobiology.

DOI10.1126/science.aar2578
Alternate JournalScience
PubMed ID29853553
Grant ListZIA MH002794 / MH / NIMH NIH HHS / United States
R01 MH107235 / MH / NIMH NIH HHS / United States
R01 NS085211 / NS / NINDS NIH HHS / United States
R01 NS060910 / NS / NINDS NIH HHS / United States
R01 MH112847 / MH / NIMH NIH HHS / United States
R01 MH107703 / MH / NIMH NIH HHS / United States
U54 MH091657 / MH / NIMH NIH HHS / United States