Noncoding RNAs in Depression.

TitleNoncoding RNAs in Depression.
Publication TypeJournal Article
Year of Publication2017
AuthorsLin R, Turecki G
JournalAdv Exp Med Biol
Volume978
Pagination197-210
Date Published2017
ISSN0065-2598
Abstract

Major depressive disorder (MDD) is a common psychiatric disorder affecting millions of people worldwide, yet its etiology remains elusive. The last decades have seen great advances in our understanding of the genome structure and functional organization. Noncoding RNAs (ncRNAs) are RNAs that do not code for proteins but have important regulatory roles. The investigation of ncRNAs as regulators of gene expression has been a topic of growing interest in health research, including in studies investigating etiological and therapeutic factors in major depression. Several different species of ncRNAs have been identified in association to and have shown to be dysregulated in depressed individuals or in animal models of depression. This review will detail the complex relation between ncRNAs and major depression and the studies that propose mechanisms and pathways that specific ncRNAs may be involved in major depression.

DOI10.1007/978-3-319-53889-1_11
Alternate JournalAdv. Exp. Med. Biol.
PubMed ID28523548