Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling.

TitleNeurons diversify astrocytes in the adult brain through sonic hedgehog signaling.
Publication TypeJournal Article
Year of Publication2016
AuthorsW Farmer T, Abrahamsson T, Chierzi S, Lui C, Zaelzer C, Jones EV, Bally BPonroy, Chen GG, Théroux J-F, Peng J, Bourque CW, Charron F, Ernst C, P Sjöström J, Murai KK
JournalScience
Volume351
Issue6275
Pagination849-54
Date Published2016 Feb 19
ISSN1095-9203
KeywordsAnimals, Astrocytes, Cerebellar Cortex, Female, Gene Deletion, Hedgehog Proteins, Male, Mice, Mice, Mutant Strains, Neurons, Receptors, G-Protein-Coupled, Signal Transduction, Smoothened Receptor
Abstract

Astrocytes are specialized and heterogeneous cells that contribute to central nervous system function and homeostasis. However, the mechanisms that create and maintain differences among astrocytes and allow them to fulfill particular physiological roles remain poorly defined. We reveal that neurons actively determine the features of astrocytes in the healthy adult brain and define a role for neuron-derived sonic hedgehog (Shh) in regulating the molecular and functional profile of astrocytes. Thus, the molecular and physiological program of astrocytes is not hardwired during development but, rather, depends on cues from neurons that drive and sustain their specialized properties.

DOI10.1126/science.aab3103
Alternate JournalScience
PubMed ID26912893
Grant ListFDN 143337 / / Canadian Institutes of Health Research / Canada
NIA 288936 / / Canadian Institutes of Health Research / Canada
MOP 111152 / / Canadian Institutes of Health Research / Canada
130175-1 / / Canadian Institutes of Health Research / Canada
MOP 123390 / / Canadian Institutes of Health Research / Canada
MOP 126137 / / Canadian Institutes of Health Research / Canada
126137-1 / / Canadian Institutes of Health Research / Canada

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