Neurodevelopmental insights into circuit dysconnectivity in schizophrenia.

TitleNeurodevelopmental insights into circuit dysconnectivity in schizophrenia.
Publication TypeJournal Article
Year of Publication2021
AuthorsNath M, Wong TPan, Srivastava LK
JournalProg Neuropsychopharmacol Biol Psychiatry
Volume104
Pagination110047
Date Published2021 Jan 10
ISSN1878-4216
Abstract

Schizophrenia is increasingly being recognized as a disorder of brain circuits of developmental origin. Animal models, however, have been technically limited in exploring the effects of early developmental circuit abnormalities on the maturation of the brain and associated behavioural outputs. This review discusses evidence of the developmental emergence of circuit abnormalities in schizophrenia, followed by a critical assessment on how animal models need to be adapted through optimized tools in order to spatially and temporally manipulate early developmental events, thereby providing insight into the causal contribution of developmental perturbations to schizophrenia.

DOI10.1016/j.pnpbp.2020.110047
Alternate JournalProg Neuropsychopharmacol Biol Psychiatry
PubMed ID32721441