Neurodevelopmental insights into circuit dysconnectivity in schizophrenia.
|Title||Neurodevelopmental insights into circuit dysconnectivity in schizophrenia.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Nath M, Wong TPan, Srivastava LK|
|Journal||Prog Neuropsychopharmacol Biol Psychiatry|
|Date Published||2021 Jan 10|
Schizophrenia is increasingly being recognized as a disorder of brain circuits of developmental origin. Animal models, however, have been technically limited in exploring the effects of early developmental circuit abnormalities on the maturation of the brain and associated behavioural outputs. This review discusses evidence of the developmental emergence of circuit abnormalities in schizophrenia, followed by a critical assessment on how animal models need to be adapted through optimized tools in order to spatially and temporally manipulate early developmental events, thereby providing insight into the causal contribution of developmental perturbations to schizophrenia.
|Alternate Journal||Prog Neuropsychopharmacol Biol Psychiatry|