Neural correlates of recognition memory of social information in people with schizophrenia.

TitleNeural correlates of recognition memory of social information in people with schizophrenia.
Publication TypeJournal Article
Year of Publication2014
AuthorsHarvey P-O, Lepage M
JournalJ Psychiatry Neurosci
Volume39
Issue2
Pagination97-109
Date Published2014 Mar
ISSN1488-2434
KeywordsAdult, Antipsychotic Agents, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Pattern Recognition, Visual, Prefrontal Cortex, Recognition (Psychology), Schizophrenia, Schizophrenic Psychology, Social Behavior
Abstract

BACKGROUND: Social dysfunction is a hallmark characteristic of schizophrenia. Part of it may stem from an inability to efficiently encode social information into memory and retrieve it later. This study focused on whether patients with schizophrenia show a memory boost for socially relevant information and engage the same neural network as controls when processing social stimuli that were previously encoded into memory.METHODS: Patients with schizophrenia and healthy controls performed a social and nonsocial picture recognition memory task while being scanned. We calculated memory performance using d'. Our main analysis focused on brain activity associated with recognition memory of social and nonsocial pictures.RESULTS: Our study included 28 patients with schizophrenia and 26 controls. Healthy controls demonstrated a memory boost for socially relevant information. In contrast, patients with schizophrenia failed to show enhanced recognition sensitivity for social pictures. At the neural level, patients did not engage the dorsomedial prefrontal cortex (DMPFC) as much as controls while recognizing social pictures.LIMITATIONS: Our study did not include direct measures of self-referential processing. All but 3 patients were taking antipsychotic medications, which may have altered both the behavioural performance during the picture recognition memory task and brain activity.CONCLUSION: Impaired social memory in patients with schizophrenia may be associated with altered DMPFC activity. A reduction of DMPFC activity may reflect less involvement of self-referential processes during memory retrieval. Our functional MRI results contribute to a better mapping of the neural disturbances associated with social memory impairment in patients with schizophrenia and may facilitate the development of innovative treatments, such as transcranial magnetic stimulation.

Alternate JournalJ Psychiatry Neurosci
PubMed ID24119792
PubMed Central IDPMC3937286
Grant List53280 / / Canadian Institutes of Health Research / Canada

  • Douglas Hospital
  • Dobell Pavillion
  • Brain imaging centre