The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence.

TitleThe Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence.
Publication TypeJournal Article
Year of Publication2019
AuthorsVosberg DE, Leyton M, Flores C
JournalMol Psychiatry
Date Published2019 Oct 28
ISSN1476-5578
Abstract

Axon guidance molecules direct growing axons toward their targets, assembling the intricate wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC (deleted in colorectal cancer), has profound effects, in laboratory animals, on the adolescent expansion of mesocorticolimbic pathways, particularly dopamine. Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in Netrin-1 and DCC are associated with depression, schizophrenia, and substance use. Together, these findings provide compelling evidence that Netrin-1 and DCC influence mesocorticolimbic-related psychopathological states that emerge during adolescence.

DOI10.1038/s41380-019-0561-7
Alternate JournalMol. Psychiatry
PubMed ID31659271
Grant ListR01DA037911 / / U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) /
2982226 / / Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology) /
MOP-74709, 119543 / / Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) /
MOP-119543, 133537, 152910 / / Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre) /