Naguib Mechawar, PhD

Naguib Mechawar, PhD

Contact

 naguib.mechawar@mcgill.ca

 

6875 Boulevard LaSalle
Montréal, QC
H4H 1R3

 Bureau:F-2101.1, Frank B. Common Pavilion

 Telephone bureau: (514) 761-6131 x3365

  Site web du laboratoire:https://mgss.ca/naguib-mechawar

Chercheur, Centre de recherche Douglas
Chef de groupe, Stress, anxiété, dépression et suicide
Directeur, Banque de cerveaux Douglas-Bell Canada, Centre de recherche Douglas
Professeur, Département de psychiatrie, Université McGill
Directeur du programme d’études supérieures, Département de psychiatrie, Université McGill

Co-Directeur, Réseau québécois sur le suicide, les troubles de l’humeur et les troubles associés – RQSHA

Nom du laboratoire: Neuroanatomie des troubles de l'humeur et du suicide

Groupe thématique: Stress, anxiété, dépression et suicide
Division: Neuroscience humaine

 

Naguib Mechawar, Ph.D., s’est joint à l’Institut Douglas et au Groupe McGill d’études sur le suicide (GMES) en 2007. Il étudie les substrats neurochimiques et neuroanatomiques qui sous-tendent la dépression majeure et le suicide. Il s’intéresse tout particulièrement aux régions conséquences durables de l’adversité chez l’enfant.

Dans son laboratoire, il travaille notamment sur:

  • La neuroinflammation dans la dépression et le suicide
  • La neuroplasticité dans le cerveau humain
  • Les anomalies astrocytiques dans la dépression et le suicide
  • Les effets à long terme de l’abus infantile sur les oligodendrocytes du cerveau et la myélinisation.

Les recherches du Dr Mechawar sont financées (en 2020) par les IRSC, le CRSNG, ERA-NET Neuron (FRQ-S), et HBHL (CFREF).

Nouveau Chercheur IRSC (2012-17)
Boursier Senior en Santé Mental Bell (2012-14)

Lab members:

  • Maria Antonietta Davoli (research assistant)
  • Reza Rahimian (postdoctoral fellow)
  • Marina Wakid (PhD student)
  • Claudia Belliveau (PhD student)
  • Christa Hercher (PhD student)
  • Kelly Perlman (PhD student)
  • Refilwe Mpai (MSc student)
  • Candice Canonne (MSc student)
  • Sophie Simard (MSc student)

Alumni:

  • Liam O’Leary (PhD student)
  • Arnaud Tanti (postdoctoral fellow)
  • George Perlman (research technician)
  • Emily Clark (undergraduate research student)
  • Ashley McFarquhar (undergraduate research student)
  • Cynthia McMahan (undergraduate research student)
  • Christopher Ma (undergraduate research student)
  • Kimiya Adjedani (undergraduate research student)
  • Katharine Birkness (undergraduate research student)
  • Fanny Denux (undergraduate research student)
  • Katie Vandeloo (undergraduate research student)
  • John Kim (MSc student)
  • Qiyuan Huang (visiting PhD student)
  • Madelyn Barton (undergraduate research student)
  • Marilyn Cyr (PhD student, co-supervised by M-A Bédard)
  • Julia Devorak (MSc student)
  • Haseeb Khan (undergraduate research student)
  • Alexander Freibauer (undergraduate research student)
  • Sandra Yogendran (undergraduate research student)
  • Archchun Ariyarajah (undergraduate research student)
  • Samuel Comeau (undergraduate research student)
  • Diana Elwell (undergraduate research student)
  • Erika Freemantle (PhD student, co-supervised by G. Turecki)
  • Christa Hercher (MSc student, co-supervised by G. Turecki)
  • Alexandra Hoehne (undergraduate research student)
  • Masanobu Ito (postdoctoral fellow)
  • Donald MacIsaac (undergraduate research student)
  • Calvin Qiang (undergraduate research student)
  • Adeline Rachalski (postdoctoral fellow)
  • Stephanie Tan (undergraduate research student)
  • Ian Mahar (PhD student)
  • Marissa Maheu (PhD student)
  • Susana Gabriela Torres-Platas (PhD student)
  • Dominique Mirault (research technician)

  Publications sur PubMed

  Profil Google Scholar

  • Tanti A, Lutz P-E, Kim J, O’Leary L, Turecki G, Mechawar N (2019) Evidence of decreased gap junction between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides. Neuropsychopharmacology 44:2099-2111.
  • Tanti A, Kim JJ, Wakid M, Davoli MA, Turecki G, Mechawar N (2018) Child abuse associates with an imbalance of oligodendrocyte-lineage cells in ventromedial prefrontal white matter. Mol Psychiatry 23:2018-2028.
  • Lutz PE, Tanti A, Gasecka A, Barnett-Burns S, Kim JJ, Zhou Y, Chen GG, Wakid M, Shaw M, Almeida D, Chay MA, Yang J, Larivière V, M’Boutchou MN, van Kempen LC, Yerko V, Prud’homme J, Davoli MA, Vaillancourt K, Théroux JF, Bramoullé A, Zhang TY, Meaney MJ, Ernst C, Côté D, Mechawar N*, Turecki G* (2017) Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence. Am J Psychiatry 174:1185-1194.
  • Mahar I, Labonte B, Yogendran S, Isingrini E, Perret L, Davoli MA, Rachalski A, Giros B, Turecki G, Mechawar N (2017) Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide. Transl Psychiatry 7:e1161.
  • Mechawar N, Savitz J (2016) Neuropathology of mood disorders: do we see the stigmata of inflammation? Transl Psychiatry 6:e946.
  • Torres-Platas SG, Nagy C, Wakid M, Turecki G, Mechawar N (2016) Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and downregulated in the thalamus and caudate nucleus of depressed suicides. Mol Psychiatry 21:509-515.
  • Torres-Platas SG, Cruceanu C, Chen GG, Turecki G, Mechawar N (2014) Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun 42:50-59.
  • Maheu M, Davoli MA, Turecki G, Mechawar N (2013) Amygdalar expression of proteins associated with neuroplasticity in major depression and suicide. J Psych Res 47:384-390.

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