n-back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants: preliminary findings.

Titlen-back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants: preliminary findings.
Publication TypeJournal Article
Year of Publication2015
AuthorsIsrael M, Klein M, Pruessner J, Thaler L, Spilka M, Efanov S, Ouellette A-S, Berlim M, Ali N, Beaudry T, Van den Eynde F, C-D Walker, Steiger H
JournalPsychiatry Res
Volume232
Issue1
Pagination84-91
Date Published2015 Apr 30
ISSN1872-7123
KeywordsAdolescent, Adult, Brain, Bulimia, Executive Function, Feeding and Eating Disorders, Feeding Behavior, Female, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Task Performance and Analysis, Young Adult
Abstract

Eating disorder (ED) variants characterized by "binge-eating/purging" symptoms differ from "restricting-only" variants along diverse clinical dimensions, but few studies have compared people with these different eating-disorder phenotypes on measures of neurocognitive function and brain activation. We tested the performances of 19 women with "restricting-only" eating syndromes and 27 with "binge-eating/purging" variants on a modified n-back task, and used functional magnetic resonance imaging (fMRI) to examine task-induced brain activations in frontal regions of interest. When compared with "binge-eating/purging" participants, "restricting-only" participants showed superior performance. Furthermore, in an intermediate-demand condition, "binge-eating/purging" participants showed significantly less event-related activation than did "restricting-only" participants in a right posterior prefrontal region spanning Brodmann areas 6-8-a region that has been linked to planning of motor responses, working memory for sequential information, and management of uncertainty. Our findings suggest that working memory is poorer in eating-disordered individuals with binge-eating/purging behaviors than in those who solely restrict food intake, and that observed performance differences coincide with interpretable group-based activation differences in a frontal region thought to subserve planning and decision making.

DOI10.1016/j.pscychresns.2015.01.022
Alternate JournalPsychiatry Res
PubMed ID25707581