n-back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants: preliminary findings.
|Title||n-back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants: preliminary findings.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Israel M, Klein M, Pruessner J, Thaler L, Spilka M, Efanov S, Ouellette A-S, Berlim M, Ali N, Beaudry T, Van den Eynde F, C-D Walker, Steiger H|
|Date Published||2015 Apr 30|
|Keywords||Adolescent, Adult, Brain, Bulimia, Executive Function, Feeding and Eating Disorders, Feeding Behavior, Female, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Task Performance and Analysis, Young Adult|
Eating disorder (ED) variants characterized by "binge-eating/purging" symptoms differ from "restricting-only" variants along diverse clinical dimensions, but few studies have compared people with these different eating-disorder phenotypes on measures of neurocognitive function and brain activation. We tested the performances of 19 women with "restricting-only" eating syndromes and 27 with "binge-eating/purging" variants on a modified n-back task, and used functional magnetic resonance imaging (fMRI) to examine task-induced brain activations in frontal regions of interest. When compared with "binge-eating/purging" participants, "restricting-only" participants showed superior performance. Furthermore, in an intermediate-demand condition, "binge-eating/purging" participants showed significantly less event-related activation than did "restricting-only" participants in a right posterior prefrontal region spanning Brodmann areas 6-8-a region that has been linked to planning of motor responses, working memory for sequential information, and management of uncertainty. Our findings suggest that working memory is poorer in eating-disordered individuals with binge-eating/purging behaviors than in those who solely restrict food intake, and that observed performance differences coincide with interpretable group-based activation differences in a frontal region thought to subserve planning and decision making.
|Alternate Journal||Psychiatry Res|