Molecular Imaging of the Cholinergic System in Alzheimer and Lewy Body Dementias: Expanding Views.
|Title||Molecular Imaging of the Cholinergic System in Alzheimer and Lewy Body Dementias: Expanding Views.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Kanel P, Bedard M-A, Aghourian M, Rosa-Neto P, Soucy J-P, Albin RL, Bohnen NI|
|Journal||Curr Neurol Neurosci Rep|
|Date Published||2021 09 20|
|Keywords||Alzheimer Disease, Brain, Cholinergic Agents, Humans, Lewy Body Disease, Molecular Imaging|
PURPOSE OF REVIEW: Brain cholinergic denervation is a major feature of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). We reviewed the topography assessed by a cholinergic molecular imaging study in these two major types of dementia. A small meta-analysis directly comparing vesicular acetylcholine transporter (VAChT) PET scans of AD vs. DLB patients is presented.RECENT FINDINGS: VAChT PET studies showed evidence of extensive cortical cholinergic denervation in both forms of dementia, while multiple subcortical structures were also in DLB. Novel analysis revealed evidence of metathalamic denervation in AD, and epithalamus, premotor/sensorimotor cortical, and striatal losses in DLB. Topographically distinct cortical and subcortical cholinergic lesions can distinguish AD and DLB, and new structures have been highlighted here. Differential vulnerability of specific cholinergic projections is likely associated with specific clinical features of these disorders. Improved understanding of the mechanisms and roles of cholinergic neurotransmission in regions with cholinergic deficits may lead to symptomatic therapies.
|Alternate Journal||Curr Neurol Neurosci Rep|
|Grant List||P01 NS015655 / NH / NIH HHS / United States |
R01 NS070856 / NH / NIH HHS / United States
P50 NS091856 / NH / NIH HHS / United States
I01 RX001631 / RX / RRD VA / United States